中国山东省淋浴水中环境嗜肺军团菌分离株的抗菌药物敏感性特征
Antimicrobial susceptibility profile of environmental Legionella pneumophila isolates from shower water in Shandong Province, China.
摘要(中文译文)
目前关于中国环境嗜肺军团菌菌株抗菌药物敏感性的数据有限。本研究调查了从中国山东省公共洗浴设施淋浴水中分离的嗜肺军团菌菌株对六种常用于治疗军团病的抗菌药物的敏感性，从而为建立国际ECOFF值提供区域数据。所有六种抗菌药物均检测到敏感性降低的菌株。红霉素的非野生型菌株率最高（35株，MIC > 0.5，MIC50 = 0.75 mg/L，MIC90 = 12 mg/L）。利福平次之（32株，MIC > 0.032，MIC50 = 0.047 mg/L，MIC90 = 0.25 mg/L）。左氧氟沙星（25株，MIC > 0.25，MIC50 = 0.38 mg/L，MIC90 = 1.5 mg/L）。阿奇霉素（21株，MIC > 0.25，MIC50 = 0.125 mg/L，MIC90 = 2 mg/L）。莫西沙星（17株，MIC > 1，MIC50 = 1 mg/L，MIC90 = 6 mg/L）。头孢呋辛缺乏暂定ECOFF值；大多数菌株MIC = 16，MIC50 = 12 mg/L。血清群1与其他血清群之间未发现显著MIC差异（p > 0.05）。研究表明，中国的嗜肺军团菌表现出具有地域特异性的药物敏感性降低。氟喹诺酮类药物是军团菌肺炎的一线治疗药物。
Abstract
Limited data are available on the antimicrobial susceptibility of environmental Legionella pneumophila strains in China. This study investigated the susceptibility of Legionella pneumophila strains isolated from shower water in public bathing facilities in Shandong Province, China, to six commonly used antimicrobial agents for treating Legionnaires' disease, thereby providing regional data for establishing international ECOFF values. Reduced susceptibility strains were detected in all six antimicrobial agents. Erythromycin exhibited the highest rate of non-wild type strains (35 strains, MIC > 0.5, MIC50 = 0.75 mg/L, MIC90 = 12 mg/L). Rifampin followed (32 strains, MIC > 0.032, MIC50 = 0.047 mg/L, MIC90 = 0.25 mg/L). Levofloxacin (25 strains, MIC > 0.25, MIC50 = 0.38 mg/L, MIC90 = 1.5 mg/L). Azithromycin (21 strains, MIC > 0.25, MIC50 = 0.125 mg/L, MIC90 = 2 mg/L). Moxifloxacin (17 strains, MIC > 1, MIC50 = 1 mg/L, MIC90 = 6 mg/L). Cefuroxime lacks a provisional ECOFF value; most strains had MIC = 16, MIC50 = 12 mg/L. No significant MIC difference was found between serogroup 1 and other serogroups (p > 0.05). Research indicates that Legionella pneumophila in China exhibits geographically specific reduced drug susceptibility. Fluoroquinolones are the first-line treatment for Legionella pneumonia.
如何引用
AMA
Yuanyuan Jiang, Chuan Qin, Bin Hu, Lianlong Yu, Xiao Zhang, Yanxin Gao, et al. Antimicrobial susceptibility profile of environmental Legionella pneumophila isolates from shower water in Shandong Province, China.. Scientific reports. 2026; doi:10.1038/s41598-026-60919-7.
APA
Yuanyuan Jiang, Chuan Qin, Bin Hu, Lianlong Yu, Xiao Zhang, Yanxin Gao, et al (2026). Antimicrobial susceptibility profile of environmental Legionella pneumophila isolates from shower water in Shandong Province, China.. Scientific reports. https://doi.org/10.1038/s41598-026-60919-7
GB/T 7714
Yuanyuan Jiang, Chuan Qin, Bin Hu, Lianlong Yu, Xiao Zhang, Yanxin Gao, et al. Antimicrobial susceptibility profile of environmental Legionella pneumophila isolates from shower water in Shandong Province, China.[J]. Scientific reports, 2026 doi:10.1038/s41598-026-60919-7.
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