小鼠辐射死亡率模型：辐射医学对策生存结果的范围综述和荟萃分析
Mouse model of radiation mortality: scoping review and meta-analysis of survival outcomes of radiation medical countermeasures.
摘要(中文译文)
本研究系统梳理了2014年至2024年间发表的小分子辐射医学防护剂（RMCs）小鼠体内研究，并聚焦于与造血型急性辐射综合征（H-ARS）相关的全身照射或全淋巴照射（WBI/TBI）模型开展定量生存分析。小鼠模型在辐射生物学中具有核心地位，因其可提供受控、可重复的系统，用于研究辐射损伤、测试候选治疗药物并生成与临床转化相关的临床前证据。通过结构化PubMed检索共识别出5558条记录，其中258项研究符合纳入标准。提取了研究特征与结局，并对生存研究按全身照射或全淋巴照射、适宜剂量范围、Kaplan-Meier报告及数据完整性进行筛选。为减少异质性，荟萃分析仅限于暴露于7.5-9.5 Gy全身照射的C57BL/6小鼠。在118项生存研究中，48个队列符合条件，但仅8.0-8.5 Gy和8.5-9.0 Gy剂量范围支持定量合成。采用限制性平均生存时间（RMST；τ=30天）进行合并分析显示，与对照队列相比，治疗队列的生存获益分别为12天和13天。多种化学结构不同的辐射医学防护剂均改善了生存，其中δ-生育三烯酚衍生物的效应最大。这些发现既凸显了小鼠模型的转化价值，也表明需要在实验设计和报告方面实现更高程度的标准化。
Abstract
This study systematically maps murine in vivo research on small-molecule radiation medical countermeasures (RMCs) published between 2014 and 2024, with quantitative survival analysis focused on whole or total-body irradiation (WBI/TBI) models relevant to hematopoietic acute radiation syndrome (H-ARS). Murine models are central to radiation biology because they provide controlled, reproducible systems for studying radiation injury, testing candidate therapeutics, and generating preclinical evidence relevant to clinical translation. A structured PubMed search identified 5,558 records, of which 258 studies met inclusion criteria. Study characteristics and outcomes were extracted, and survival studies were filtered for (WBI/TBI), appropriate dose range, Kaplan-Meier reporting, and data integrity. To reduce heterogeneity, meta-analysis was restricted to C57BL/6 mice exposed to 7.5-9.5 Gy WBI. Of 118 survival studies, 48 cohorts were eligible, but only the 8.0-8.5 Gy and 8.5-9.0 Gy dose ranges supported quantitative synthesis. Using restricted mean survival time (RMST; τ = 30 days), pooled analysis showed survival gains of 12 and 13 days, respectively, in treated versus control cohorts. Multiple chemically distinct RMCs improved survival, with the largest effects observed for delta-tocotrienol derivatives. These findings highlight both the translational value of murine models and the need for greater standardization in experimental design and reporting.
如何引用
AMA
Natalie Zivna, Vojtech Chmil, Jan Marek, Ales Tichy, Martina Rezacova, Alena Mrkvicova. Mouse model of radiation mortality: scoping review and meta-analysis of survival outcomes of radiation medical countermeasures.. Scientific reports. 2026; doi:10.1038/s41598-026-60348-6.
APA
Natalie Zivna, Vojtech Chmil, Jan Marek, Ales Tichy, Martina Rezacova, Alena Mrkvicova (2026). Mouse model of radiation mortality: scoping review and meta-analysis of survival outcomes of radiation medical countermeasures.. Scientific reports. https://doi.org/10.1038/s41598-026-60348-6
GB/T 7714
Natalie Zivna, Vojtech Chmil, Jan Marek, Ales Tichy, Martina Rezacova, Alena Mrkvicova. Mouse model of radiation mortality: scoping review and meta-analysis of survival outcomes of radiation medical countermeasures.[J]. Scientific reports, 2026 doi:10.1038/s41598-026-60348-6.
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