角膜屈光微透镜提取后设计参数对外周散焦的影响
Influence of design parameters on peripheral defocus after keratorefractive lenticule extraction.
摘要(中文译文)
本研究探讨了角膜屈光微透镜取出术（KLEx）前后周边离焦的变化，并考察了手术设计参数与周边离焦变化之间的关联。本前瞻性纵向前后对照研究纳入78例自愿选择接受KLEx的近视患者，患者于2023年3月至7月在中国天津天津医科大学天津市眼科医院视光中心就诊。根据球镜等效屈光误差将患者分为三组。使用多光谱屈光地形图于术前及术后3个月测量0°-53°视野范围内的视网膜相对离焦值（RDV）。采用配对样本t检验比较术前与术后变化。采用Pearson相关分析分析手术参数与RDV变化之间的关联。KLEx术后3个月，10°-20°范围内近视性离焦增加，20°-30°范围内RDV由远视性离焦转变为近视性离焦，30°-40°及40°-53°范围内远视性离焦减少。中央角膜切削厚度与40°-53°范围内RDV变化呈正相关。组织改变百分比（PTA）与30°-40°及40°-53°范围内RDV变化呈正相关。KLEx术后周边远视性离焦减少。中央角膜切削厚度似乎是KLEx术后周边离焦变化的重要相关因素。术中角膜切削厚度越大，术后周边远视性离焦减少越明显。
Abstract
This study investigated changes in peripheral defocus before and after keratorefractive lenticule extraction (KLEx) and examined the associations between surgical design parameters and changes in peripheral defocus. This prospective longitudinal pre-post study included 78 patients with myopia who voluntarily chose to undergo KLEx from March to July 2023 at the Optometry Center of Tianjin Eye Hospital, Tianjin Medical University, Tianjin, China. Patients were divided into three groups according to spherical equivalent refractive error. Retinal relative defocus values (RDVs) within the 0°-53° field were measured using multispectral refractive topography before surgery and 3 months postoperatively. Paired-sample t-tests were used to compare preoperative and postoperative changes. Associations between surgical parameters and changes in RDVs were analyzed using Pearson's correlation analysis. Three months after KLEx, myopic defocus increased at 10°-20°, the RDV at 20°-30° shifted from hyperopic to myopic defocus, and hyperopic defocus decreased at 30°-40° and 40°-53°. Central corneal cutting thickness was positively correlated with the change in RDV at 40°-53°. Percent tissue altered (PTA) was positively correlated with changes in RDVs at 30°-40° and 40-53°. Peripheral hyperopic defocus was reduced after KLEx. Central corneal cutting thickness appears to be an important factor associated with changes in peripheral defocus after KLEx. Greater corneal cutting thickness during surgery was associated with a greater postoperative reduction in peripheral hyperopic defocus.
如何引用
AMA
Shijia Qu, He Tian, Xiaoyan Yang, Qiwen Chen, Fen Song, Shaohu Bai, et al. Influence of design parameters on peripheral defocus after keratorefractive lenticule extraction.. Scientific reports. 2026; doi:10.1038/s41598-026-60744-y.
APA
Shijia Qu, He Tian, Xiaoyan Yang, Qiwen Chen, Fen Song, Shaohu Bai, et al (2026). Influence of design parameters on peripheral defocus after keratorefractive lenticule extraction.. Scientific reports. https://doi.org/10.1038/s41598-026-60744-y
GB/T 7714
Shijia Qu, He Tian, Xiaoyan Yang, Qiwen Chen, Fen Song, Shaohu Bai, et al. Influence of design parameters on peripheral defocus after keratorefractive lenticule extraction.[J]. Scientific reports, 2026 doi:10.1038/s41598-026-60744-y.
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