Kikuchi-Fujimoto病的临床病理特征：巴基斯坦回顾性病例系列
Clinicopathological Characteristics of Kikuchi-Fujimoto Disease: A Retrospective Case Series from Pakistan.
摘要(中文译文)
背景 菊池-藤本病（Kikuchi-Fujimoto disease，KFD），又称组织细胞性坏死性淋巴结炎，是一种罕见、良性且通常自限性的疾病，常见表现为颈部淋巴结肿大、发热和全身症状。该病最多见于年轻亚洲成年人。其病因尚不明确，组织病理学检查对于确诊及排除淋巴瘤和狼疮性淋巴结炎等重要相似疾病至关重要。方法 本回顾性病例系列纳入2000年1月至2024年1月期间在Shaukat Khanum纪念癌症医院和研究中心诊断和管理的10例经组织病理学确诊的KFD患者。收集并分析临床、病理和实验室数据。结果 10例患者平均年龄为26.3±7岁。女性8例，男性2例，男女比例为4:1。颈部淋巴结肿大是最常见的表现。6例（60%）患者报告发热，体重下降和肌痛/关节痛各报告2例（20%）。2例患者有处于缓解期的淋巴系统恶性肿瘤。未记录到自身免疫性疾病，但未常规进行抗核抗体（ANA）检测。结论 本病例系列突出了KFD临床表现的多样性，并强调了组织病理学诊断在淋巴结肿大患者中的重要性。需要更大规模的前瞻性研究以更好地了解其相关因素和结局。
Abstract
Background Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotising lymphadenitis, is a rare, benign, and usually self-limiting condition that commonly presents with cervical lymphadenopathy, fever, and constitutional symptoms. It is most often reported in young Asian adults. Its aetiology remains unclear, and histopathological examination is essential to confirm the diagnosis and exclude important mimics such as lymphoma and lupus lymphadenitis. Methods This retrospective case series included 10 patients with histopathologically confirmed KFD who were diagnosed and managed at Shaukat Khanum Memorial Cancer Hospital and Research Centre between January 2000 and January 2024. Clinical, pathological, and laboratory data were collected and analysed. Results Among the 10 patients, the mean age was 26.3 ± 7 years. Eight were female patients, and two were male patients, resulting in a female-to-male ratio of 4:1. Cervical lymphadenopathy was the most common presentation. Fever was reported in six patients (60%), while weight loss and myalgia/arthralgia were each reported in two patients (20%). Two patients had lymphoid malignancies in remission. No autoimmune diseases were documented, although antinuclear antibody (ANA) testing was not performed routinely. Conclusion This case series highlights the varied clinical presentation of KFD and reinforces the importance of histopathological diagnosis in patients presenting with lymphadenopathy. Larger prospective studies are needed to better understand its associations and outcomes.
如何引用
AMA
Hanzla Maryam, Seemal Aslam, Muhammad Awais Kanwal, Salma Abbas, Tariq Mehmood, Muhammad Fasial, et al. Clinicopathological Characteristics of Kikuchi-Fujimoto Disease: A Retrospective Case Series from Pakistan.. Cureus. 2026; doi:10.7759/cureus.110059.
APA
Hanzla Maryam, Seemal Aslam, Muhammad Awais Kanwal, Salma Abbas, Tariq Mehmood, Muhammad Fasial, et al (2026). Clinicopathological Characteristics of Kikuchi-Fujimoto Disease: A Retrospective Case Series from Pakistan.. Cureus. https://doi.org/10.7759/cureus.110059
GB/T 7714
Hanzla Maryam, Seemal Aslam, Muhammad Awais Kanwal, Salma Abbas, Tariq Mehmood, Muhammad Fasial, et al. Clinicopathological Characteristics of Kikuchi-Fujimoto Disease: A Retrospective Case Series from Pakistan.[J]. Cureus, 2026 doi:10.7759/cureus.110059.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出