Physical performance and DEXA-derived body composition in adults with Parkinson's disease participating in a community-based exercise program and community-dwelling older adults: a cross-sectional study.
帕金森病（PD）是一种与衰老密切相关的进行性神经退行性疾病，直接影响活动能力和身体功能。尽管规律运动被广泛认为是减缓功能衰退的重要策略，但在参与社区运动项目的帕金森病成人中，同时评估身体表现和双能X线吸收法（DEXA）测定体成分的证据仍然有限，尤其是在拉丁美洲环境中。本研究采用横断面观察性研究设计。评估了参与社区运动项目的帕金森病成人及社区居住老年人。身体表现采用步速、握力、五次坐立试验、单腿平衡试验（SLBT）、计时起立行走（TUG）试验、2分钟踏步试验和简易体能状况量表（SPPB）进行评估。体成分和骨密度（BMD）采用DEXA评估。采用倾向性评分匹配，匹配变量为体重指数（BMI）和性别。数据分析采用描述性统计、Spearman相关分析和多元线性回归模型。帕金森病成人的身体表现显著低于社区居住老年人，其中步速的组间差异最大。在本模型中，帕金森病状态是步速最强的负向预测因子，而肌肉力量和功能耐力与运动表现呈正相关。DEXA测定的瘦体重与步速无独立关联。在本样本中，参与社区运动项目的帕金森病成人身体表现低于社区居住老年人。帕金森病状态是步速最强的预测因子，而肌肉力量和功能耐力与活动能力表现呈正相关。
Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with ageing that directly affects mobility and physical function. Although regular exercise is widely recognized as an important strategy to attenuate functional decline, limited evidence has simultaneously examined physical performance and body composition assessed by dual-energy X-ray absorptiometry (DEXA) in adults with Parkinson's disease participating in community-based exercise programs, particularly in Latin American settings. A cross-sectional observational study was conducted. Adults with PD participating in a community-based exercise program and community-dwelling older adults were evaluated. Physical performance was assessed using gait speed, handgrip strength, the five-times chair stand test, the single-leg balance test (SLBT), the Timed Up and Go (TUG) test, the 2-minute step test, and the Short Physical Performance Battery (SPPB). Body composition and bone mineral density (BMD) were assessed using DEXA. Propensity score matching was applied using body mass index (BMI) and sex. Descriptive statistics, Spearman correlations, and multiple linear regression models were used for data analysis. Adults with PD showed significantly lower physical performance than community-dwelling older adults, with gait speed exhibiting the largest between-group difference. In the present model, Parkinson's disease status was the strongest negative predictor of gait speed, whereas muscle strength and functional endurance were positively associated with locomotor performance. DEXA-derived lean mass was not independently associated with gait speed. Within the present sample, adults with PD participating in a community-based exercise program exhibited lower physical performance than community-dwelling older adults. Parkinson's disease status emerged as the strongest predictor of gait speed, whereas muscle strength and functional endurance were positively associated with mobility performance.
Nicole Fritz-Silva, Graciela Gallegos-Vega, Cristian Mansilla-Antilef, Carol Ule-Marín, Carla Bittner-Hoffman. Physical performance and DEXA-derived body composition in adults with Parkinson's disease participating in a community-based exercise program and community-dwelling older adults: a cross-sectional study.. Scientific reports. 2026; doi:10.1038/s41598-026-60968-y.
Nicole Fritz-Silva, Graciela Gallegos-Vega, Cristian Mansilla-Antilef, Carol Ule-Marín, Carla Bittner-Hoffman (2026). Physical performance and DEXA-derived body composition in adults with Parkinson's disease participating in a community-based exercise program and community-dwelling older adults: a cross-sectional study.. Scientific reports. https://doi.org/10.1038/s41598-026-60968-y
Nicole Fritz-Silva, Graciela Gallegos-Vega, Cristian Mansilla-Antilef, Carol Ule-Marín, Carla Bittner-Hoffman. Physical performance and DEXA-derived body composition in adults with Parkinson's disease participating in a community-based exercise program and community-dwelling older adults: a cross-sectional study.[J]. Scientific reports, 2026 doi:10.1038/s41598-026-60968-y.
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出