{“_”：“通过复合凝聚将胆酸微胶囊化可增强对.的持续释放和抗菌活性。”，“i”：[“大肠杆菌”]}
{"_":"Microencapsulation of cholic acid via complex coacervation enhances sustained release and antibacterial activity against .","i":["Escherichia coli"]}
摘要(中文译文)
本研究旨在开发一种微囊化胆酸（CA）制剂，以提高胆酸的稳定性、缓释性能和抗菌活性，为其在无抗动物生产中的潜在应用提供依据。以明胶和阿拉伯胶为壁材，采用复凝聚法制备胆酸微囊，并通过单因素和正交试验设计对处方进行优化。最佳制备条件为壁材浓度2.5%、芯壁比1.8：1、pH 4.1，在此条件下载药率为49.73%，包封率为88.76%。微囊呈球形，吸湿性低，热稳定性和贮存稳定性均得到改善，并在模拟胃肠介质中表现出72 h的缓释特性。游离胆酸和微囊化胆酸均能显著抑制生长（<0.001），而微囊可提供与控释特性相一致的更持久的抗菌效果。上述结果表明，复凝聚法是改善胆酸性能的一种实用策略，并支持胆酸微囊作为抗菌饲料添加剂在畜牧生产中的潜在应用。
Abstract
This study aimed to develop a microencapsulated cholic acid (CA) preparation to improve the stability, sustained-release performance, and antibacterial activity of CA for potential use in antibiotic-free animal production. CA microcapsules were prepared by complex coacervation using gelatin and gum arabic as wall materials, and the formulation was optimized by single-factor and orthogonal experimental designs. The optimal preparation conditions were a wall material concentration of 2.5%, a core-to-wall ratio of 1.8:1, and pH 4.1, yielding a drug loading rate of 49.73% and an encapsulation efficiency of 88.76%. The microcapsules showed spherical morphology, low hygroscopicity, improved thermal and storage stability, and a sustained-release profile over 72 h in simulated gastrointestinal media. Both free CA and microencapsulated CA significantly inhibited growth ( < 0.001), while the microcapsules provided a more prolonged antibacterial effect consistent with controlled release. These findings indicate that complex coacervation is a practical strategy for improving CA performance and support the potential use of CA microcapsules as antimicrobial feed additives in livestock production.
如何引用
AMA
Xiuling He, Ganggang Qu, Danqi Shen, Jing Lu, Haobo Li, Wei Mao, et al. {"_":"Microencapsulation of cholic acid via complex coacervation enhances sustained release and antibacterial activity against .","i":["Escherichia coli"]}. Frontiers in veterinary science. 2026; doi:10.3389/fvets.2026.1874445.
APA
Xiuling He, Ganggang Qu, Danqi Shen, Jing Lu, Haobo Li, Wei Mao, et al (2026). {"_":"Microencapsulation of cholic acid via complex coacervation enhances sustained release and antibacterial activity against .","i":["Escherichia coli"]}. Frontiers in veterinary science. https://doi.org/10.3389/fvets.2026.1874445
GB/T 7714
Xiuling He, Ganggang Qu, Danqi Shen, Jing Lu, Haobo Li, Wei Mao, et al. {"_":"Microencapsulation of cholic acid via complex coacervation enhances sustained release and antibacterial activity against .","i":["Escherichia coli"]}[J]. Frontiers in veterinary science, 2026 doi:10.3389/fvets.2026.1874445.
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