肠道菌群来源的色氨酸代谢物：分子机制、营养策略及其对猪健康的意义
Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health.
摘要(中文译文)
色氨酸作为一种必需氨基酸，具有营养价值。除此之外，它还是连接肠道微生物群与宿主生理的重要信号分子。宿主介导的通路已被充分表征，而微生物群驱动的吲哚通路已成为宿主稳态的主要调节因素。共生细菌将未吸收的色氨酸代谢为吲哚-3-丙酸（IPA）、吲哚-3-乳酸（ILA）及其他生物活性吲哚衍生物。这些生物活性吲哚衍生物可作为芳香烃受体（AhR）和孕烷X受体（PXR）的配体。本综述总结了主要的色氨酸代谢通路，并阐明了色氨酸来源的微生物代谢物恢复肠道屏障完整性、维持免疫稳态和调节宿主代谢的分子机制。在此基础上，我们讨论了营养策略（如膳食模式和益生菌干预）及其调节色氨酸代谢的潜力。以猪作为转化模型，我们总结了这些代谢物在缓解断奶应激和改善生长性能方面的潜在应用。本综述聚焦于色氨酸代谢，为猪生产中的微生物组干预和精准营养策略提供了理论基础。
Abstract
Tryptophan, an essential amino acid, has nutritional value. Beyond that, it is an important signaling molecule that connects the gut microbiota with host physiology. While host-mediated pathways are well-characterized, the microbiota-driven indole pathway has emerged as a major modulator of host homeostasis. Commensal bacteria metabolize unabsorbed tryptophan into indole-3-propionic acid (IPA), indole-3-lactic acid (ILA) and other bioactive indole derivatives. These bioactive indole derivatives can act as ligands for aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR). This review makes a summary of the main tryptophan metabolic pathways. It also elucidates the molecular mechanisms by which microbial metabolites derived from tryptophan restore the integrity of the intestinal barrier, maintain immune homeostasis, and modulate host metabolism. Building on this, we discuss nutritional strategies, such as dietary patterns and probiotic interventions, and their potential to modulate tryptophan metabolism. Using pigs as a translational model, we summarize the potential applications of these metabolites in alleviating weaning stress and improving growth performance. This review focuses on tryptophan metabolism and provides a theoretical basis for microbiome interventions and precision nutrition strategies in swine production.
如何引用
AMA
Yang Wen. Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health.. Frontiers in veterinary science. 2026; doi:10.3389/fvets.2026.1807477.
APA
Yang Wen (2026). Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health.. Frontiers in veterinary science. https://doi.org/10.3389/fvets.2026.1807477
GB/T 7714
Yang Wen. Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health.[J]. Frontiers in veterinary science, 2026 doi:10.3389/fvets.2026.1807477.
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