{"_":"A Synbiotic of Lacto--tetraose and subsp. MN-Gup Attenuates High-Fat Diet-Induced Obesity by Modulating Metabolism and Gut Microbiota in Mice.","i":["N","Bifidobacterium animalis","lactis"]}
肥胖与肠道菌群失调、肠道屏障功能障碍以及糖脂代谢受损密切相关。然而，单一益生菌或益生元干预往往仅能带来有限的代谢改善。本研究旨在评估由乳糖-N-四糖（LNT）与MN-Gup亚种（MN-Gup）组成的合生元制剂在高脂饮食（HFD）诱导的肥胖小鼠模型中的效果。本研究采用HFD诱导的肥胖小鼠模型，探究LNT与MN-Gup合生元制剂能否改善肥胖相关的代谢紊乱、肠道屏障功能障碍及肠道菌群失衡。小鼠分别接受单用LNT、单用MN-Gup或不同剂量的合生元制剂处理。分析血清生化指标、葡萄糖耐量、血脂谱、肝脏组织病理学、肠道屏障标志物、肠道菌群组成及短链脂肪酸（SCFA）水平。高剂量合生元干预在降低体重增长、改善葡萄糖耐量和血脂谱、减轻肝脏脂质蓄积和损伤方面显著优于单组分处理。这些代谢变化伴随肠道屏障完整性标志物的改善和肠道菌群组成的调节，其特征为有益菌属（如、和）的富集以及肥胖相关菌群（包括、、、、和）的减少。Spearman相关性分析揭示了微生物变化与宿主代谢标志物之间的关联。综上所述，这些研究结果表明，由高剂量LNT和MN-Gup组成的合生元制剂对管理小鼠高脂饮食诱导的代谢紊乱具有潜在益处。
Obesity is closely associated with gut microbiota dysbiosis, intestinal barrier dysfunction, and impaired glucose and lipid metabolism. However, single probiotic or prebiotic interventions often yield only limited metabolic improvements. This study aimed to evaluate the effects of a synbiotic formulation comprising Lacto--tetraose (LNT) and subsp. MN-Gup (MN-Gup) in a high-fat diet (HFD)-induced obese mouse model. In this study, an HFD-induced obese mouse model was used to investigate whether the synbiotic formulation of LNT and MN-Gup could ameliorate obesity-related metabolic dysregulation, intestinal barrier dysfunction, and gut microbiota imbalance. Mice were treated with LNT alone, MN-Gup alone, or the synbiotic at different doses. Serum biochemical parameters, glucose tolerance, lipid profiles, liver histopathology, intestinal barrier markers, gut microbiota composition, short-chain fatty acid (SCFA) levels were analyzed. High-dose synbiotic intervention significantly outperformed single-component treatments in reducing weight gain, improving glucose tolerance and lipid profiles, and attenuating hepatic lipid accumulation and injury in mice. These metabolic changes were accompanied by improved markers of intestinal barrier integrity and modulation of gut microbiota composition, characterized by the enrichment of beneficial genera (e.g., , , and ) alongside a reduction in obesity-associated taxa (including , , , , , and ). Spearman correlation analysis revealed associative links between microbial alterations and host metabolic markers. Collectively, these findings suggest that the synbiotic formulation comprising high-dose LNT and MN-Gup offers potential benefits for managing high-fat diet-induced metabolic dysregulation in mice.
Ying Luo, Yang Li, Linjun Wu, Xiaoqiong Li, Xiangyu Bian, Jian Kuang, et al. {"_":"A Synbiotic of Lacto--tetraose and subsp. MN-Gup Attenuates High-Fat Diet-Induced Obesity by Modulating Metabolism and Gut Microbiota in Mice.","i":["N","Bifidobacterium animalis","lactis"]}. Nutrients. 2026; doi:10.3390/nu18111681.
Ying Luo, Yang Li, Linjun Wu, Xiaoqiong Li, Xiangyu Bian, Jian Kuang, et al (2026). {"_":"A Synbiotic of Lacto--tetraose and subsp. MN-Gup Attenuates High-Fat Diet-Induced Obesity by Modulating Metabolism and Gut Microbiota in Mice.","i":["N","Bifidobacterium animalis","lactis"]}. Nutrients. https://doi.org/10.3390/nu18111681
Ying Luo, Yang Li, Linjun Wu, Xiaoqiong Li, Xiangyu Bian, Jian Kuang, et al. {"_":"A Synbiotic of Lacto--tetraose and subsp. MN-Gup Attenuates High-Fat Diet-Induced Obesity by Modulating Metabolism and Gut Microbiota in Mice.","i":["N","Bifidobacterium animalis","lactis"]}[J]. Nutrients, 2026 doi:10.3390/nu18111681.
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