FORWARD研究中儿童患者和护理人员多重IgE介导的食物过敏的心理社会负担
Psychosocial Burden of Multiple IgE-Mediated Food Allergies in Pediatric Patients and Caregivers in the FORWARD Study.
摘要(中文译文)
在美国约8%患有食物过敏（FA）的儿童中，大约40%报告对多种食物过敏。食物过敏管理的普遍性和强度可能给儿科患者和照护者带来心理社会负担，而在对多种食物过敏的人群中，这种负担可能进一步加重。然而，目前很少有研究在经临床确诊食物过敏的异质性儿科人群中全面评估多种食物过敏的负担。经过敏专科医生诊断为IgE介导的食物过敏的儿童被纳入FORWARD多中心前瞻性队列研究。心理社会负担每年使用食物过敏生活质量问卷-家长版10（FAQL-PF10）和食物过敏独立性测量-家长版（FAIM-PF）进行评估；照护者的心理社会负担使用食物过敏生活质量-家长负担问卷（FAQL-PB）进行测量。多水平回归模型在调整儿童年龄、性别、种族、民族、家庭收入、照护者教育程度、特应性共病和招募中心后，估计当前食物过敏数量的独立效应。在控制年龄、性别、种族、民族、收入、教育和其他特应性疾病等人口学因素以及参与者内重复观察后，患者和照护者的食物过敏相关心理社会负担随每一种额外当前食物过敏呈线性增加：FAQL-PF10 B = 0.082（= 2206；= 0.004），FAIM-PF B = 0.152（= 2206；< 0.001），FAQL-PB B = 0.166（= 1081；< 0.001）。儿科食物过敏的心理社会负担随每一种额外当前食物过敏呈单调增加，凸显了为受影响最严重者提供量身定制的心理社会、行为和药物干预以改善食物过敏相关结局的机会。
Abstract
: Of the approximately 8% of children in the United States (US) with food allergy (FA), roughly 40% report allergy to multiple foods. The ubiquity and intensity of FA management can impose psychosocial burdens on both pediatric patients and caregivers, which may be exacerbated among those allergic to multiple foods. However, little work has comprehensively estimated the burden of multi-FA in heterogeneous pediatric populations with clinically confirmed FA. : Children with allergist-diagnosed, IgE-mediated FA were enrolled in the FORWARD multisite prospective cohort study. Psychosocial burden was assessed annually using the FA Quality of Life Questionnaire-Parent Form 10 (FAQL-PF10) and FA Independent Measure-Parent Form (FAIM-PF); psychosocial burden for caregivers was measured with the FA Quality of Life-Parental Burden (FAQL-PB) Questionnaire. Multilevel regression models estimated independent effects of the number of current FAs after adjusting for child age, gender, race, ethnicity, household income, caregiver education, atopic comorbidities, and recruitment site. : FA-related psychosocial burden increased linearly for patients and caregivers with each additional FA even after controlling for demographic factors such as age, gender, race, ethnicity, income, education, and other atopic conditions, as well as repeated observations within participants: FAQL-PF10 B = 0.082 ( = 2206; = 0.004), FAIM-PF B = 0.152 ( = 2206; < 0.001), and FAQL-PB B = 0.166 ( = 1081; < 0.001). : The psychosocial burden of pediatric FA increases monotonically with each additional current FA, highlighting opportunities for tailored psychosocial, behavioral, and pharmacologic interventions to improve FA-related outcomes among those most impacted.
如何引用
AMA
Mariesa Cay, Caglar Onal, Linda Herbert, Melissa Engel, Hemant Sharma, Mahdavinia Mahboobeh, et al. Psychosocial Burden of Multiple IgE-Mediated Food Allergies in Pediatric Patients and Caregivers in the FORWARD Study.. Nutrients. 2026; doi:10.3390/nu18111745.
APA
Mariesa Cay, Caglar Onal, Linda Herbert, Melissa Engel, Hemant Sharma, Mahdavinia Mahboobeh, et al (2026). Psychosocial Burden of Multiple IgE-Mediated Food Allergies in Pediatric Patients and Caregivers in the FORWARD Study.. Nutrients. https://doi.org/10.3390/nu18111745
GB/T 7714
Mariesa Cay, Caglar Onal, Linda Herbert, Melissa Engel, Hemant Sharma, Mahdavinia Mahboobeh, et al. Psychosocial Burden of Multiple IgE-Mediated Food Allergies in Pediatric Patients and Caregivers in the FORWARD Study.[J]. Nutrients, 2026 doi:10.3390/nu18111745.
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