犬咬伤的代价：由犬咬二氧化碳嗜纤维菌感染继发的多器官衰竭需要静脉-静脉体外膜氧合（VV-ECMO）支持
Price of a Dog Bite: Multiorgan Failure Secondary to Capnocytophaga canimorsus Infection Requiring Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) Support.
摘要(中文译文)
是一种人畜共患的革兰阴性杆菌，常存在于犬和猫的口腔菌群中。尽管人类感染并不常见，但可导致快速进展且危及生命的疾病，尤其是在免疫功能受损者（如无脾患者）中。需要体外膜氧合（ECMO）支持的严重急性呼吸窘迫综合征（ARDS）鲜有报道。我们描述一位60岁女性患者，患有甲状腺功能减退症，并有远期脾切除术史，在犬咬伤一周后出现发热、乏力及胃肠道症状。住院早期采集的血培养生长出该菌。其临床病程并发快速进展的ARDS和多器官功能衰竭，需要有创机械通气。尽管采用了优化的肺保护性通气、神经肌肉阻滞、俯卧位通气及广谱抗菌治疗，难治性低氧血症仍持续存在。作为挽救治疗启动静脉-静脉（VV）ECMO，气体交换和肺力学逐步改善。ECMO支持在11天后成功撤除，随后脱离机械通气并完全临床康复。严重的该菌感染可导致暴发性ARDS和多器官功能障碍。早期识别并及时升级至高级支持治疗（包括VV-ECMO）对特定患者可能具有挽救生命的意义。
Abstract
is a zoonotic Gram-negative bacterium commonly present in the oral flora of dogs and cats. Although human infection is uncommon, it can lead to rapidly progressive and life-threatening disease, particularly in immunocompromised individuals such as those with asplenia. Severe acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO) has been rarely reported. We describe a 60-year-old woman with hypothyroidism and a remote history of splenectomy who presented with fever, malaise, and gastrointestinal symptoms one week after a dog bite. Blood cultures obtained early during hospitalization grew . Her clinical course was complicated by rapidly progressive ARDS and multiorgan failure, requiring invasive mechanical ventilation. Despite optimized lung-protective ventilation, neuromuscular blockade, prone positioning, and broad-spectrum antimicrobial therapy, refractory hypoxemia persisted. Veno-venous (VV) ECMO was initiated as rescue therapy, resulting in progressive improvement in gas exchange and pulmonary mechanics. ECMO support was successfully discontinued after 11 days, followed by liberation from mechanical ventilation and full clinical recovery. Severe infection can result in fulminant ARDS and multiorgan dysfunction. Early recognition and timely escalation to advanced supportive therapies, including VV-ECMO, may be lifesaving in selected patients.
如何引用
AMA
Juan D Salazar Borbón, Daniel Xu Carranza, Pablo A Alvarez Aguilar, Luis Quiros Figueroa. Price of a Dog Bite: Multiorgan Failure Secondary to Capnocytophaga canimorsus Infection Requiring Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) Support.. Cureus. 2026; doi:10.7759/cureus.108881.
APA
Juan D Salazar Borbón, Daniel Xu Carranza, Pablo A Alvarez Aguilar, Luis Quiros Figueroa (2026). Price of a Dog Bite: Multiorgan Failure Secondary to Capnocytophaga canimorsus Infection Requiring Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) Support.. Cureus. https://doi.org/10.7759/cureus.108881
GB/T 7714
Juan D Salazar Borbón, Daniel Xu Carranza, Pablo A Alvarez Aguilar, Luis Quiros Figueroa. Price of a Dog Bite: Multiorgan Failure Secondary to Capnocytophaga canimorsus Infection Requiring Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) Support.[J]. Cureus, 2026 doi:10.7759/cureus.108881.
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