解读酒渣鼻和偏头痛之间的神经联系：探索共享机制
Decoding the Neurological Connection Between Rosacea and Migraines: Exploring Shared Mechanisms.
摘要(中文译文)
玫瑰痤疮与偏头痛是常见的慢性疾病，传统上被视为分别影响不同器官系统的独立疾病。然而，越来越多的证据表明两者存在显著重叠，尤其是通过共享的神经血管和神经炎症通路。本文献综述探讨了玫瑰痤疮——一种以面部潮红和敏感为特征的慢性炎症性皮肤病——与偏头痛——一种以反复头痛为特征的神经系统疾病——之间的关联机制。当前研究强调了神经肽的关键作用，包括降钙素基因相关肽（CGRP）、P物质（SP）和垂体腺苷酸环化酶激活多肽（PACAP），它们在介导两种疾病共有的炎症和血管调节异常中发挥重要作用。尽管取得了这些进展，仍存在显著的研究空白，例如关于偏头痛治疗（如CGRP抑制剂）对玫瑰痤疮影响的数据有限、这两种疾病选择性共病的原因尚不明确、将玫瑰痤疮与其他头痛疾病进行比较的研究极少，以及各项研究存在方法学局限性。通过跨学科研究填补这些空白有望改善临床结局。本综述强调了将玫瑰痤疮和偏头痛视为相互关联的神经血管疾病的重要性，倡导整合性治疗策略，并为未来研究提出了方向。
Abstract
Rosacea and migraine are prevalent chronic disorders traditionally viewed as distinct conditions affecting separate organ systems. However, emerging evidence suggests a significant overlap, notably through shared neurovascular and neuroinflammatory pathways. This literature review explores the mechanisms linking rosacea, a chronic inflammatory skin condition characterized by facial flushing and sensitivity, and migraine, a neurological disorder marked by recurrent headaches. Current research highlights the critical roles of neuropeptides, including calcitonin gene-related peptide (CGRP), substance P (SP), and pituitary adenylate cyclase-activating polypeptide (PACAP), in mediating inflammation and vascular dysregulation common to both conditions. Despite these advances, notable gaps remain, such as limited data on the impact of migraine treatments (e.g., CGRP inhibitors) on rosacea, unclear reasons behind the selective comorbidity of these conditions, minimal research comparing rosacea to other headache disorders, and methodological limitations across studies. Addressing these gaps through interdisciplinary research holds promise for improved clinical outcomes. This review underscores the importance of recognizing rosacea and migraine as interrelated neurovascular disorders, advocating for integrated therapeutic approaches, and proposing directions for future research.
如何引用
AMA
Aymen Arain, Maryam Babar, Nina Martins, Danny Lee. Decoding the Neurological Connection Between Rosacea and Migraines: Exploring Shared Mechanisms.. Cureus. 2026; doi:10.7759/cureus.108668.
APA
Aymen Arain, Maryam Babar, Nina Martins, Danny Lee (2026). Decoding the Neurological Connection Between Rosacea and Migraines: Exploring Shared Mechanisms.. Cureus. https://doi.org/10.7759/cureus.108668
GB/T 7714
Aymen Arain, Maryam Babar, Nina Martins, Danny Lee. Decoding the Neurological Connection Between Rosacea and Migraines: Exploring Shared Mechanisms.[J]. Cureus, 2026 doi:10.7759/cureus.108668.
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