Stevens-Johnson综合征和甲氧苄啶/磺胺甲恶唑引起的毒性表皮坏死松解重叠：病例报告
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap Induced by Trimethoprim/Sulfamethoxazole: A Case Report.
摘要(中文译文)
史蒂文斯-约翰逊综合征（SJS）与中毒性表皮坏死松解症（TEN）重叠是一种罕见、可能危及生命的皮肤超敏反应，需要及时识别和恰当治疗。药物诱发的超敏反应通常与抗菌药物、抗惊厥药和非甾体抗炎药等药物相关。本病例报告描述了一名18岁女性患者，其在初级保健机构因无症状性菌尿被处方甲氧苄啶/磺胺甲噁唑，尽管缺乏明确的临床指征，随后发生了SJS/TEN重叠，表皮剥脱累及20%的体表面积。患者在停用致病药物并接受强化支持治疗后病情改善，住院22天后出院。本病例强调了早期诊断和立即停药以改善预后的重要性。
Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) overlap is a rare, potentially life-threatening cutaneous hypersensitivity reaction that requires prompt recognition and appropriate treatment. Drug-induced hypersensitivity reactions are commonly associated with medications such as antimicrobials, anticonvulsants, and nonsteroidal anti-inflammatory drugs. This case report describes an 18-year-old female patient who was prescribed trimethoprim/sulfamethoxazole for asymptomatic bacteriuria in a primary care setting, despite the absence of a clear clinical indication, and subsequently developed SJS/TEN overlap with epidermal detachment involving 20% of the body surface area. The patient improved after withdrawal of the offending agent and intensive supportive management and was discharged after 22 days of hospitalization. This case highlights the importance of early diagnosis and immediate drug discontinuation to improve outcomes.
如何引用
AMA
Guilherme Kenzo Shimizu Saito, Gabriela Mendes da Costa Manteli, Beatris Pinheiro Dos Santos, Lucas Garrafoni Pessotti, Stefany Laura Messias, Lara Cordeiro de Faria, et al. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap Induced by Trimethoprim/Sulfamethoxazole: A Case Report.. Cureus. 2026; doi:10.7759/cureus.108225.
APA
Guilherme Kenzo Shimizu Saito, Gabriela Mendes da Costa Manteli, Beatris Pinheiro Dos Santos, Lucas Garrafoni Pessotti, Stefany Laura Messias, Lara Cordeiro de Faria, et al (2026). Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap Induced by Trimethoprim/Sulfamethoxazole: A Case Report.. Cureus. https://doi.org/10.7759/cureus.108225
GB/T 7714
Guilherme Kenzo Shimizu Saito, Gabriela Mendes da Costa Manteli, Beatris Pinheiro Dos Santos, Lucas Garrafoni Pessotti, Stefany Laura Messias, Lara Cordeiro de Faria, et al. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap Induced by Trimethoprim/Sulfamethoxazole: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.108225.
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