慢性缺铁性贫血作为长期闭经女性未诊断的Von Willebrand病的初始表现：病例报告
Chronic Iron Deficiency Anemia as the Initial Manifestation of Undiagnosed Von Willebrand Disease in a Woman With Long-Standing Menorrhagia: A Case Report.
摘要(中文译文)
缺铁性贫血是育龄期女性常见的临床疾病，常被归因于妇科失血。然而，潜在的遗传性出血性疾病仍是尚未被充分认识的相关因素。我们报告一例女性患者，表现为慢性疲劳、乏力及长期月经过多，曾多次因缺铁性贫血接受治疗但未见持续改善。随后的血液学评估发现血管性血友病因子（VWF）缺乏，符合血管性血友病。本病例强调了将异常子宫出血识别为潜在止血障碍可能表现的重要性，并指出需要早期进行诊断性评估，以防止长期患病并避免延误确定性治疗。
Abstract
Iron deficiency anemia is a common clinical condition in reproductive‑age women and is frequently attributed to gynecologic blood loss. However, underlying inherited bleeding disorders remain underrecognized contributors. We present a case of a woman with chronic fatigue, weakness, and long-standing menorrhagia who was repeatedly treated for iron deficiency anemia without sustained improvement. Subsequent hematologic evaluation revealed Von Willebrand factor (VWF) deficiency consistent with Von Willebrand disease. This case highlights the importance of recognizing abnormal uterine bleeding as a potential manifestation of an underlying hemostatic disorder and underscores the need for early diagnostic evaluation to prevent prolonged morbidity and avoid delays in definitive management.
如何引用
AMA
Shamas Rafique, Iqra Rafiq. Chronic Iron Deficiency Anemia as the Initial Manifestation of Undiagnosed Von Willebrand Disease in a Woman With Long-Standing Menorrhagia: A Case Report.. Cureus. 2026; doi:10.7759/cureus.108255.
APA
Shamas Rafique, Iqra Rafiq (2026). Chronic Iron Deficiency Anemia as the Initial Manifestation of Undiagnosed Von Willebrand Disease in a Woman With Long-Standing Menorrhagia: A Case Report.. Cureus. https://doi.org/10.7759/cureus.108255
GB/T 7714
Shamas Rafique, Iqra Rafiq. Chronic Iron Deficiency Anemia as the Initial Manifestation of Undiagnosed Von Willebrand Disease in a Woman With Long-Standing Menorrhagia: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.108255.
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