分娩时母体维生素D状态和青春期早期过敏结果：来自KLOTHO出生队列的前瞻性发现
Maternal Vitamin D Status at Delivery and Allergic Outcomes in Early Adolescence: Prospective Findings from the KLOTHO Birth Cohort.
摘要(中文译文)
产前维生素D暴露被认为是子代免疫发育及后续过敏性疾病风险的潜在决定因素；然而，长期队列数据仍不一致。我们分析了KLOTHO出生队列的数据，纳入98名具有可用过敏结局评估的青少年。维生素D分析使用了一个母-新生儿亚队列，该队列由在分娩时具有可用母体和新生儿血清总25-羟基维生素D[25(OH)D]测量值的母子对组成。过敏结局包括子代哮喘、过敏性鼻炎和湿疹。采用描述性统计、Spearman相关分析和logistic回归模型评估关联。母体25(OH)D浓度与哮喘（ρ = 0.075，= 0.652）、过敏性鼻炎（ρ = 0.100，= 0.556）或湿疹（ρ = 0.131，= 0.426）均无显著关联。在粗logistic回归模型中，维生素D浓度与哮喘（每10 nmol/L的比值比（OR）：1.07，95%置信区间（CI）：0.78-1.48，= 0.67）、过敏性鼻炎（OR：1.05，95% CI：0.76-1.45，= 0.77）或湿疹（OR：1.17，95% CI：0.86-1.60，= 0.31）均无关联。纳入母亲年龄、孕前体重指数（BMI）、分娩季节和紫外线暴露的校正模型得出了类似的非显著结果，尽管分析受到完整病例样本量减少的限制。在这个随访至青春期早期的前瞻性队列中，分娩时的维生素D状态与子代哮喘、过敏性鼻炎或湿疹均无关联。这些发现支持缺乏统计学显著关联；然而，鉴于样本量有限，潜在的非线性关系应谨慎解读。
Abstract
Prenatal vitamin D exposure has been proposed as a potential determinant of immune development and subsequent allergic disease risk in offspring; however, long-term cohort data remain inconsistent. We analyzed data from the KLOTHO birth cohort, including 98 adolescents with available allergic outcome assessment. A maternal-neonatal sub-cohort of mother-child pairs with available maternal and neonatal serum total 25-hydroxyvitamin D [25(OH)D] measurements at delivery was used for vitamin D analyses. Allergic outcomes included asthma, allergic rhinitis, and eczema in offspring. Associations were evaluated using descriptive statistics, Spearman correlation analyses, and logistic regression models. Maternal 25(OH)D concentrations were not significantly associated with asthma (ρ = 0.075, = 0.652), allergic rhinitis (ρ = 0.100, = 0.556), or eczema (ρ = 0.131, = 0.426). In crude logistic regression models, vitamin D concentrations were not associated with asthma (odds ratio (OR) per 10 nmol/L: 1.07, 95% confidence interval (CI): 0.78-1.48, = 0.67), allergic rhinitis (OR: 1.05, 95% CI: 0.76-1.45, = 0.77), or eczema (OR: 1.17, 95% CI: 0.86-1.60, = 0.31). Adjusted models including maternal age, pre-pregnancy body mass index (BMI), season of delivery, and ultraviolet exposure yielded similar non-significant findings, although analyses were limited by a reduced complete-case sample size. In this prospective cohort with follow-up into early adolescence, vitamin D status at delivery was not associated with asthma, allergic rhinitis, or eczema in offspring. These findings support a lack of statistically significant association; however, potential non-linear relationships should be interpreted cautiously, given the modest sample size.
如何引用
AMA
Spyridon N Karras, Dimitrios G Goulis, Nikolaos Angelopoulos, Vikentia Harizopoulou, Maria Kypraiou, Antonios Vlastos, et al. Maternal Vitamin D Status at Delivery and Allergic Outcomes in Early Adolescence: Prospective Findings from the KLOTHO Birth Cohort.. Nutrients. 2026; doi:10.3390/nu18081277.
APA
Spyridon N Karras, Dimitrios G Goulis, Nikolaos Angelopoulos, Vikentia Harizopoulou, Maria Kypraiou, Antonios Vlastos, et al (2026). Maternal Vitamin D Status at Delivery and Allergic Outcomes in Early Adolescence: Prospective Findings from the KLOTHO Birth Cohort.. Nutrients. https://doi.org/10.3390/nu18081277
GB/T 7714
Spyridon N Karras, Dimitrios G Goulis, Nikolaos Angelopoulos, Vikentia Harizopoulou, Maria Kypraiou, Antonios Vlastos, et al. Maternal Vitamin D Status at Delivery and Allergic Outcomes in Early Adolescence: Prospective Findings from the KLOTHO Birth Cohort.[J]. Nutrients, 2026 doi:10.3390/nu18081277.
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