广西地中海贫血现状及展望
Thalassemia in Guangxi: current situation and future prospects.
摘要(中文译文)
广西是全球地中海贫血负担最重的地区之一，普通人群携带率高达23.89%。过去15年间，广西建立了以“政府主导、多部门协作、卫生部门问责、医防融合、公众参与”为原则的政府主导、多部门联防联控网络。该体系构建了以基因检测和干细胞移植为支撑的“预防—诊断—干预—管理”一体化连续服务链。因此，2010年至2024年，重型地中海贫血出生率下降了96.46%，并连续六年保持在每万名新生儿0.3例以下。这标志着广西成功从高发区转变为国家示范区。广西模式的成功源于从被动临床治疗向主动公共卫生策略的范式转变、公共卫生与临床实践的深度融合以及持续的技术与制度创新。广西的经验表明，即使在资源有限的环境中，系统化、多层次策略也能有效控制遗传性疾病，为全球高负担地区提供了宝贵经验和因地制宜的参考。
Abstract
Guangxi, one of the regions with the highest thalassemia burden worldwide, has a carrier rate of 23.89% in the general population. Over the past 15 years, it has established a government-led, multi-sectoral prevention network based on the principles of "government leadership, multi-department coordination, healthcare sector accountability, integration of medical and preventive services, and public participation." This system has created an integrated "prevention-diagnosis-intervention-management" continuum supported by genetic testing and stem cell transplantation. Therefore, from 2010 to 2024, the birth rate of severe thalassemia decreased by 96.46%, and remained below 0.3 cases per 10,000 newborns for six consecutive years. This marks Guangxi's successful transformation from a high-incidence area to a national demonstration zone. The success of the Guangxi Model stems from a paradigm shift from reactive clinical treatment to proactive public health strategy, deep integration of public health with clinical practice, and continuous technological and systemic innovation. Guangxi's experience demonstrates that even in resource-limited settings, a systematic, multi-tiered strategy can effectively control genetic disorders, offering valuable lessons and a context-dependent reference for high-burden regions worldwide.
如何引用
AMA
Lifang Liang, Sheng He. Thalassemia in Guangxi: current situation and future prospects.. Frontiers in public health. 2026; doi:10.3389/fpubh.2026.1842288.
APA
Lifang Liang, Sheng He (2026). Thalassemia in Guangxi: current situation and future prospects.. Frontiers in public health. https://doi.org/10.3389/fpubh.2026.1842288
GB/T 7714
Lifang Liang, Sheng He. Thalassemia in Guangxi: current situation and future prospects.[J]. Frontiers in public health, 2026 doi:10.3389/fpubh.2026.1842288.
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