白藜芦醇对绝经后慢性冠心病妇女内皮祖细胞和凋亡生物标志物的影响：一项随机对照试验
The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.
摘要(中文译文)
绝经是女性重要的心血管危险因素，可能归因于雌激素的显著下降。雌激素影响动脉粥样硬化的关键过程，通过抑制内皮细胞凋亡维持内皮完整性，并通过内皮祖细胞（EPCs）促进再生。植物雌激素，如白藜芦醇，对女性心血管健康具有治疗潜力。本研究旨在确定白藜芦醇是否调节患有慢性冠心病（CHD）的绝经后女性循环凋亡生物标志物和EPCs。二十名患有慢性CHD的绝经后女性被分配至干预组，接受1，000 mg白藜芦醇或安慰剂治疗90天。评估了循环凋亡标志物（半胱天冬酶3和9、survivin、cIAP2、XIAP、Bcl-2、细胞色素c、sTNFR2和S100A12）、SIRT1和SIRT3、细胞因子及EPCs。研究结束时，白藜芦醇组显示血清cIAP2（= 0.018）和Bcl-2（= 0.043）升高，半胱天冬酶-9（= -7.152，95%CI = -13.554至-0.751）和循环CD34+/KDR+（= -0.200，95%CI = -0.304至-0.096）降低。此外，XIAP水平低于安慰剂组（= 0.047）。sirtuins、细胞因子、血脂谱、血糖和血压未见显著差异。白藜芦醇增加了患有慢性CHD的绝经后女性血清Bcl-2和cIAP2，并降低了半胱天冬酶9和循环EPCs，可能与循环SIRT1和SIRT3无关。在该人群组中应谨慎评估白藜芦醇治疗的效果，因为EPCs减少与内皮功能受损和心血管疾病风险增加相关。
Abstract
Menopause is an important cardiovascular risk factor in women likely due to marked estrogen decline. Estrogens affect key processes in atherosclerosis, maintaining endothelial integrity by inhibiting endothelial apoptosis and promoting regeneration through endothelial progenitor cells (EPCs). Phytoestrogens, such as resveratrol, have therapeutic potential for women's cardiovascular health. The present study aimed to determine whether resveratrol modulated circulating apoptosis biomarkers and EPCs in postmenopausal women with chronic coronary heart disease (CHD). Twenty postmenopausal women with chronic CHD were allocated to an intervention group receiving 1,000 mg of resveratrol or placebo for 90 days. Circulating markers of apoptosis (caspases 3 and 9, survivin, cIAP2, XIAP, Bcl-2, cytochrome c, sTNFR2, and S100A12), SIRT1 and 3, cytokines and EPCs were assessed. At the end of the study, the resveratrol group showed an increase in serum cIAP2 ( = 0.018) and Bcl-2 ( = 0.043), and a decrease in caspase-9 ( = -7.152, 95%CI = -13.554 to -0.751) and in circulating CD34+/KDR+ ( = -0.200, 95%CI = -0.304 to -0.096). In addition, XIAP levels were lower than placebo group ( = 0.047). No significant differences were observed for sirtuins, cytokines, lipid profile, glucose, and blood pressure. Resveratrol increased serum Bcl-2 and cIAP2, and also reduced caspase 9 and circulating EPCs in postmenopausal women with chronic CHD, likely unrelated to circulating SIRT1 and SIRT3. The effects of resveratrol treatment in this population group should be assessed with caution, as a reduction in EPCs is associated with impaired endothelial function and an increased risk of cardiovascular disease.
如何引用
AMA
Gustavo Henrique Ferreira Gonçalinho, Verônica Coelho, Sandra Maria Monteiro, Célia Maria Cassaro Strunz, Jorge Kalil, Antonio de Padua Mansur. The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1814668.
APA
Gustavo Henrique Ferreira Gonçalinho, Verônica Coelho, Sandra Maria Monteiro, Célia Maria Cassaro Strunz, Jorge Kalil, Antonio de Padua Mansur (2026). The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1814668
GB/T 7714
Gustavo Henrique Ferreira Gonçalinho, Verônica Coelho, Sandra Maria Monteiro, Célia Maria Cassaro Strunz, Jorge Kalil, Antonio de Padua Mansur. The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1814668.
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