胆汁酸稳态调节：一种治疗或诊断肝脏疾病的可行和通用的方法
Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders.
摘要(中文译文)
胆汁酸（BAs）的稳态失衡与多种肝脏疾病的发生和进展密切相关，包括胆汁淤积、肝纤维化、肝硬化、肝细胞癌以及MASLD/MASH。在胆汁淤积中，胆汁酸失衡诱导细胞内质网应激和线粒体功能障碍，继而导致肝细胞和胆管细胞死亡，加剧肝损伤。胆汁酸失衡还可激活肝星状细胞，促进纤维化和肝硬化。在肝细胞癌的发生和进展过程中，胆汁酸失衡有利于癌性肝细胞的存活和增殖。同样，在MASLD/MASH中，胆汁酸稳态失衡与疾病严重程度显著相关。此外，胆汁酸通过与肠道微生物的交互作用，在多种肝脏疾病的发生和进展中发挥关键作用。本综述针对每种肝脏疾病，总结胆汁酸种类的独特变化及其不同的作用机制，同时探讨胆汁酸在肝脏疾病全过程中的复杂作用及其作为诊断标志物的潜力。重要的是，本综述强调了调控胆汁酸稳态在治疗肝脏疾病中的治疗意义。
Abstract
Homeostatic imbalance of bile acids (BAs) is closely associated with the onset and progression of several liver diseases, including cholestasis, hepatic fibrosis, cirrhosis, hepatocellular carcinoma, and MASLD/MASH. In cholestasis, BAs imbalance induces cellular endoplasmic reticulum stress and mitochondrial dysfunction, which subsequently lead to hepatocellular and cholangiocellular death, exacerbating liver injury. Bile acid imbalance also activates hepatic stellate cells, promoting fibrosis and cirrhosis. During hepatocellular carcinoma development and progression, BAs imbalance favors the survival and proliferation of cancerous hepatocytes. Similarly, in MASLD/MASH, homeostatic BAs imbalance correlates significantly with disease severity. Additionally, BAs, through crosstalk with gut microbes, plays a key role in the development and progression of various liver diseases. This review focuses on each liver disease, summarizing the unique changes in BAs species and their distinct mechanisms of action, while exploring the complex role of BAs throughout the course of liver disease and their potential as diagnostic markers. Importantly, it highlights the therapeutic significance of regulating BA homeostasis in treating liver diseases.
如何引用
AMA
Qian-Qian Wu, Le-Ying Gao, Hui-Yi Feng, Hao-Lin Liu, Hui Gao, Wei Peng, et al. Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1797381.
APA
Qian-Qian Wu, Le-Ying Gao, Hui-Yi Feng, Hao-Lin Liu, Hui Gao, Wei Peng, et al (2026). Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1797381
GB/T 7714
Qian-Qian Wu, Le-Ying Gao, Hui-Yi Feng, Hao-Lin Liu, Hui Gao, Wei Peng, et al. Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1797381.
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