循环CTRP9与主动脉瓣钙化联合预测冠心病患者的冠状动脉钙化
Circulating CTRP9 and aortic valve calcification jointly predict coronary artery calcification in coronary heart disease patients.
摘要(中文译文)
血管钙化可预测不良心血管结局。CTRP9是脂联素的一种旁系同源物，具有血管保护作用。我们在一项横断面观察性研究中评估了循环CTRP9与主动脉瓣钙化（AVC）及冠状动脉钙化（CAC）的关联。九百名冠心病患者接受了超声心动图和光学相干断层扫描检查；在部分受试者中检测了血清CTRP9。采用逻辑回归分析确定CAC的决定因素。ROC分析评估了CTRP9单独及联合AVC对重度CAC的预测价值。在喂食西方饮食24周的ApoE-/-小鼠中建立AVC模型，并通过PCR和Western blot分析钙化标志物。CTRP9可独立保护免受CAC影响（OR=0.156，95% CI：0.11-0.21，<0.05）。CTRP9可预测CAC严重程度（AUC=0.74），将其与AVC联合可改善对重度CAC的预测（AUC=0.843）。Kendall's Tau-b分析表明重度AVC与CAC之间存在强相关性（τb=0.597，<0.001）。外源性CTRP9可减轻小鼠主动脉瓣钙化。较低的CTRP9水平与晚期AVC及更严重的CAC相关。将CTRP9与AVC联合可增强风险预测，凸显CTRP9作为血管钙化潜在生物标志物和治疗靶点的价值。
Abstract
Vascular calcification predicts adverse cardiovascular outcomes. CTRP9, an adiponectin paralog, has vascular protective effects. We evaluated the association of circulating CTRP9 with aortic valve calcification (AVC) and coronary artery calcification (CAC) in a cross-sectional observational study. Nine hundred coronary heart disease patients underwent echocardiography and optical coherence tomography; serum CTRP9 was measured in a subset. Logistic regression identified CAC determinants. ROC analysis assessed CTRP9 alone and combined with AVC for predicting severe CAC. AVC was modeled in ApoE-/- mice fed a Western diet for 24 weeks, with calcification markers analyzed via PCR and Western blot. CTRP9 independently protected against CAC (OR = 0.156, 95% CI: 0.11-0.21, < 0.05). CTRP9 predicted CAC severity (AUC = 0.74), and combining it with AVC improved prediction of severe CAC (AUC = 0.843). Kendall's Tau-b indicated strong correlation between severe AVC and CAC (τb = 0.597, < 0.001). Exogenous CTRP9 attenuated aortic valve calcification in mice. Lower CTRP9 levels associate with advanced AVC and greater CAC severity. Combining CTRP9 with AVC enhances risk prediction, highlighting CTRP9 as a potential biomarker and therapeutic target in vascular calcification.
如何引用
AMA
Yanru Duan, Xiaoxue Jin, Yanan Ma, Wei Sun, Lei Nie, Shizhen Zhang, et al. Circulating CTRP9 and aortic valve calcification jointly predict coronary artery calcification in coronary heart disease patients.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1783380.
APA
Yanru Duan, Xiaoxue Jin, Yanan Ma, Wei Sun, Lei Nie, Shizhen Zhang, et al (2026). Circulating CTRP9 and aortic valve calcification jointly predict coronary artery calcification in coronary heart disease patients.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1783380
GB/T 7714
Yanru Duan, Xiaoxue Jin, Yanan Ma, Wei Sun, Lei Nie, Shizhen Zhang, et al. Circulating CTRP9 and aortic valve calcification jointly predict coronary artery calcification in coronary heart disease patients.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1783380.
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