必需矿物质与胰腺疾病风险：一项大规模前瞻性队列研究
Essential minerals and risk of pancreatic diseases: a large-scale prospective cohort study.
摘要(中文译文)
胰腺疾病以高死亡率和有限的治疗选择为特征，构成全球健康挑战。作为兼具内分泌和外分泌功能的双重功能器官，胰腺对矿物质稳态的紊乱表现出高度敏感性。然而，矿物质失衡与胰腺疾病之间的病理生理关联仍存在争议，且缺乏验证这些关系的大规模人群研究。本前瞻性队列研究使用英国生物银行（UK Biobank）的数据，纳入191,875名参与者，中位随访时间为13年。采用全表型关联研究（PheWAS）系统评估矿物质水平与多系统疾病之间的关联。多因素Cox比例风险回归模型量化风险关联，而限制性立方样条分析阐明剂量-反应关系。PheWAS在消化系统内识别出多个显著关联，包括胆石症、胃炎/十二指肠炎和胰腺疾病。血清碘和硒水平升高对胰腺癌表现出显著的致癌效应。相反，铜、镁和锰对急性胰腺炎表现出保护效应，其中锰呈现U型剂量-反应关系。亚组分析显示，碘和硒的致癌性在女性、老年人和吸烟者中增强，而金属相关的保护作用在男性和正常体重个体中更为明显。矿物质稳态对消化系统病理生理产生系统性影响。碘和硒水平升高是胰腺癌变的可改变危险因素，尤其在女性和老年人群中。铜、镁和锰与急性胰腺炎的负相关提示它们是潜在的治疗靶点。慢性胰腺炎中关联的减弱意味着非矿物质机制在病因学中占主导地位。
Abstract
Pancreatic disorders are characterised by high mortality rates and limited therapeutic options and pose a global health challenge. As a dual-function organ with endocrine and exocrine roles, the pancreas exhibits a heightened sensitivity to the disruption of mineral homeostasis. However, the pathophysiological associations between mineral imbalances and pancreatic diseases remain controversial, and large-scale population studies validating these relationships are lacking. This prospective cohort study used data from the UK Biobank and enrolled 191,875 participants with a median follow-up of 13 years. A phenome-wide association study (PheWAS) was used to systematically evaluate the associations between mineral levels and multisystem disorders. Multivariate Cox proportional hazards regression models quantified risk associations, whereas restricted cubic spline analyses elucidated dose-response relationships. PheWAS identified multiple significant associations within the digestive system, including cholelithiasis, gastritis/duodenitis, and pancreatic diseases. Elevated serum iodine and selenium levels demonstrated significant carcinogenic effects on pancreatic cancer. In contrast, copper, magnesium, and manganese exhibited protective effects against acute pancreatitis, with manganese displaying a U-shaped dose-response relationship. Subgroup analyses revealed increased iodine and selenium carcinogenicity in females, older individuals, and smokers, whereas metal-related protection was more pronounced in males and normal-weight individuals. Mineral homeostasis exerts systemic effects on digestive pathophysiology. Elevated iodine and selenium levels are modifiable risk factors for pancreatic carcinogenesis, particularly in females and older populations. The inverse association of copper, magnesium, and manganese with acute pancreatitis suggests that they are potential therapeutic targets. The attenuated association in chronic pancreatitis implies an etiological predominance of non-mineral mechanisms.
如何引用
AMA
Pengwei Cao, Zhihua Shui, Xinyu Zhang, Endi Zhou, Tan Liang, Feng Cao, et al. Essential minerals and risk of pancreatic diseases: a large-scale prospective cohort study.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1773339.
APA
Pengwei Cao, Zhihua Shui, Xinyu Zhang, Endi Zhou, Tan Liang, Feng Cao, et al (2026). Essential minerals and risk of pancreatic diseases: a large-scale prospective cohort study.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1773339
GB/T 7714
Pengwei Cao, Zhihua Shui, Xinyu Zhang, Endi Zhou, Tan Liang, Feng Cao, et al. Essential minerals and risk of pancreatic diseases: a large-scale prospective cohort study.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1773339.
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