口腔溃疡 oral ulcer - PubMed 文献(第 3 页)
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口腔溃疡 的 PubMed 搜索结果(第 3 页)
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Eosinophilic ulcer of the tongue--Case report. 舌嗜酸性溃疡——病例报告
Eosinophilic ulcer of the oral mucosa is a rare, self-limiting, chronic and benign lesion of unknown pathogenesis that affects the oral mucosa. We present the case of a 65 year-old Caucasian female with a five month history of a painful ulcer on the lateral side of her tongue. The ulcer was not adhered to the underlying structures and there was no evidence of regional lymph node involvement. Laboratory examinations and X-rays revealed no abnormalities. Topical treatments had been performed without any improvement. Histopathological examination showed an ulcerated surface and mixed inflammatory infiltrate with several eosinophils extending into the mucosa and submucosa. No cellular atypia was observed. Based on the patient-s history and mucosal biopsy, a final diagnosis of eosinophilic ulcer of the oral mucosa was made.
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{"_":"HPLC/MS Profiling and Healing Activity of a Muco-Adhesive Formula of against Acetic Acid-Induced Oral Ulcer in Rats.","sup":["n"],"i":["Salvadora persica"]} {"_":"HPLC/MS分析及黏膜黏附制剂对乙酸诱导大鼠口腔溃疡的愈合活性研究。","sup":["n"],"i":["Salvadora persica"]}
L. (, Siwak) is an ethnic plant that is widely used for improving oral hygiene. This study aimed to provide a phytochemical profiling of ethyl acetate fraction (SPEAF) and to evaluate the healing activity of a muco-adhesive formula of the fraction against acetic acid-induced oral ulcers in rats. HPLC-ESI-QTOF-MS-MS analysis of SPEAF resulted in the tentative identification of 56 metabolites containing fatty acids (23%), urea derivatives (10.5%) and sulphur compounds (10%), in addition to several amides, polyphenols and organic acids (6.5%, 5% and 2%, respectively). For the first time, 19 compounds were identified from In vitro and in vivo experiments indicated that the extract is non-toxic. SPEAF exhibited superior healing activities compared to both the negative and positive control groups on days 7 and 14 of tongue ulcer induction. This was confirmed by histopathological examinations of haematoxylin and eosin-stained (H&E) and Masson's trichrome-stained tongue sections. Moreover, SPEAF showed potent anti-inflammatory activities, as evidenced by the inhibited expression of interleukin-6 (IL-6) and tumour necrosis alpha (TNF-α). Moreover, SPEAF exhibited potent antioxidant activity, as it prevented malondialdehyde (MDA) accumulation, reduced glutathione (GSH) depletion and superoxide dismutase (SOD) exhaustion. SPEAF significantly enhanced hydroxyproline tongue content and upregulated collagen type I alpha 1 (Col1A1) mRNA expression. SPEAF also improved angiogenesis, as shown by the increased mRNA expression of the angiopoietin-1 (Ang-1). In conclusion, has a wide range of secondary metabolites and ameliorates acetic acid-induced tongue ulcers in rats. This can be attributed, at least partly, to its anti-inflammatory, antioxidant, procollagen and angiogenic activities. These findings provide support and validity for the use of as a traditional and conventional treatment for oral disorders.
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Traumatic ulcerative granuloma with stromal eosinophilia. 伴基质嗜酸性粒细胞浸润的创伤性溃疡性肉芽肿
Chronic ulcers of the oral mucosa are the lesions which a physician comes across frequently. "Eosinophilic Ulcer" is a rare variety of that. Eosinophilic ulcer or traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a chronic benign lesion of the oral mucosa and is a relatively recent delineated entity. Its etiopathogenesis is still uncertain but trauma seems to play a fundamental role. Clinically the lesion manifests as an isolated ulcer, showing a raised and indurated border in addition to a white or yellowish bed. Microscopically, it is characterized by diffuse polymorphic inflammatory infiltrate, rich in eosinophils, involving the superficial mucosa and the deeper muscle layer with epitheliod cells. Hereby, reporting a case of a 60-year-old female patient who presented with a chief complaint of non-healing painful ulcer on the tongue.
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Oral medicine--update for the dental practitioner. Mouth ulcers of more serious connotation. 口腔医学----牙科医生的最新情况。口腔溃疡的内涵更为严重
This series provides an overview of current thinking in the more relevant areas of oral medicine for primary care practitioners, written by the authors while they were holding the Presidencies of the European Association for Oral Medicine and the British Society for Oral Medicine, respectively. A book containing additional material will be published. The series gives the detail necessary to assist the primary dental clinical team caring for patients with oral complaints that may be seen in general dental practice. Space precludes inclusion of illustrations of uncommon or rare disorders, or discussion of disorders affecting the hard tissues. Approaching the subject mainly by the symptomatic approach--as it largely relates to the presenting complaint--was considered to be a more helpful approach for GDPs rather than taking a diagnostic category approach. The clinical aspects of the relevant disorders are discussed, including a brief overview of the aetiology, detail on the clinical features and how the diagnosis is made. Guidance on management and when to refer is also provided, along with relevant websites which offer further detail.
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Conservative management of Riga-Fede disease. Riga-Fede病的保守治疗
Riga-Fede disease presents in early infancy and is characterized by firm, verrucous plaques arising on the oral mucosal surfaces or tongue due to repetitive trauma. Treatment focuses on eliminating the source of trauma. The purpose of this report is to present a case involving preservation of the natal teeth using a protective mouthguard. At the follow-up, the ulcer had healed and the infant was feeding without difficulties.
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Oral ulcerations are associated with the loss of response to infliximab in Crohn's disease. 口腔溃疡与克罗恩病患者英夫利昔单抗应答丧失相关
We describe a 25-year-old Caucasian man with a 13-year history of inflammatory Crohn's disease (CD) who was suffering recurrent severe oral and esophageal ulcerations for the past 3 years. His CD had been treated with infliximab infusions among other medications. The loss of efficacy was confirmed by antibodies to infliximab (ATI) and serum infliximab tests that showed high levels of ATIs and undetectable levels of infliximab respectively. These findings were consistent with significant immunogenic response to infliximab leading to loss of effect. Infliximab infusions and prednisone were discontinued and treatment of the CD was instituted with adalimumab, a human anti-tumor necrosis factor (TNF)-alpha biologic agent, to control the inflammatory small intestinal disease and dapsone for the oral and esophageal CD ulcerations. The patient's oral and esophageal lesions as well as the enteric CD are under control after 5 months of therapy.
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Microvascular imaging and monitoring of human oral cavity lesions in vivo by swept-source OCT-based angiography. 通过扫描源OCT血管造影对人体口腔病变进行体内微血管成像和监测
We report the development of optical coherence tomography- (OCT) based angiography (OCTA) to image blood flow within microcirculatory tissue beds in human oral cavity in vivo with a field of view at 10 mm × 10 mm. Three-dimensional (3D) structural and vascular images of labial mucosa tissue are obtained at a single 3D acquisition. Pathologic mucosal sites with mouth ulcers are examined using the OCT tomograms and angiograms, upon which to monitor the lesion healing process over a period of 2 weeks. Quantitative metrics of the capillary loop density within the lamina propria layer are evaluated, providing statistically significant difference between healthy and diseased conditions over time. Furthermore, tissue anatomy and vessel morphology of other susceptible sites to ulcer, such as tongue, alveolar mucosa, and labial frenulum, are also imaged to demonstrate the promise of the proposed method as a clinically useful tool for the diagnosis and monitoring of therapeutic treatment of oral tissue abnormalities.
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Detection of human herpesvirus-8 DNA in oral ulcer tissues of HIV-infected individuals. HIV感染者口腔溃疡组织中人类疱疹病毒-8 DNA的检测
To determine the frequency of detection of human herpesvirus-8 (HHV-8) in HIV-related oral ulcers. Analysis of archived biopsy material. Nested polymerase chain reaction of DNA extracts. HHV-8 DNA was detected in six of 10 oral ulcers of HIV-positive patients without oral Kaposi's sarcoma (KS) lesions and five of 11 oral KS lesions. The positive non-KS samples were derived from various oral sites. In HIV-positive people, HHV-8 can infect oral tissues that are not affected by KS.
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Lymphomatoid papulosis: A challenge in the differential diagnosis of ulcerative lesions of the oral mucosa. 淋巴瘤样丘疹病：口腔黏膜溃疡性病变鉴别诊断中的挑战
Lymphomatoid papulosis (LyP) is a primary cutaneous CD30+ lymphoproliferative disorder, with a higher incidence in males. Despite its benign and self-resolving clinical course, it exhibits histological features that may mimic other conditions. Mucosal involvement in LyP represents an atypical presentation. We report the case of a 50-year-old man with oral and genital mucosal lesions, initially diagnosed as Behçet's disease. Following a systematic review, 35 additional cases of LyP with mucosal involvement were identified, more frequently in women and with a predilection for the tongue. In 55% of patients, mucosal involvement constituted the initial manifestation of the disease, leading to diagnostic delays and misdiagnosis in one-third of cases. The prognosis was similar to that of classic LyP, with no increased risk of secondary neoplasms. Regarding therapeutic management, methotrexate and topical corticosteroids emerged as the main treatment options.
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Chronic lingual ulceration caused by lipoma of the oral cavity. Case report. 口腔脂肪瘤引起的慢性舌部溃疡。病例报告
Although lipomas are among the most frequent tumors in the human body, their presentation in the oral cavity is not common. Oral cavity lipomas usually show a slow painless and assymptomatic growing. When these tumors reach big sizes, they can cause compressive symptons and deformities. In this paper we present the case of a patient in whom oral lipoma was the final finding in the differential diagnosis of a chronic mucosal ulcer. CT scan and MRI images and microscopical examination after fine-needle aspiration were the clue for the final diagnosis. The surgical excision of the tumor was the basis for the healing of the ulcer. We also review the most relevant and recent literature about clinic, diagnosis and treatment for these tumors.