CLINICAL AND EXPERIMENTAL RHEUMATOLOGY临床与实验风湿病学
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY(英文缩写 CLIN EXP RHEUMATOL),ISSN 0392-856X,eISSN 1593-098X,中文译名:临床与实验风湿病学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.862 | Q2 |
| 2022 | 3.700 | Q3 |
| 2023 | 3.400 | Q2 |
| 2024 | 3.300 | Q2 |
| 2025 | 3.200 | Q2 |
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 最新收录文献
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1. Monitoring disease activity in eosinophilic granulomatosis with polyangiitis: a scoping review.
PMID:日期:2026-09-17Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis characterised by eosinophilic inflammation, asthma, and often anti-neutrophil cytoplasmic antibody (ANCA) positivity. Monitoring disease activity is challenging because conventional tools, mainly the Birmingham Vasculitis Activity Score (BVAS), account for manifestations not relevant to EGPA while insufficiently capturing respiratory and eosinophilic features.This scoping review aims to systematically evaluate current methods, biomarkers, imaging studies or other procedures to monitor disease activity or treatment response in EGPA. Eligible studies were those published between January 2005 and March 2025, including at least five EGPA patients (≥10% of the cohort), and focusing on disease activity or treatment response. Non-human studies, case reports, reviews, and investigations focused on diagnosis were excluded. Of 874 records screened, 58 studies met inclusion criteria. Clinical studies frequently adopted MIRRA trial definitions of remission (BVAS=0, prednisone ≤4 mg/day), but criteria varied across studies, with the most adopted secondary endpoints being oral glucocorticoid sparing, changes in eosinophil count and in pulmonary function. Biomarker investigations explored conventional lab parameters as well as emerging molecular candidates, but none achieved consistent reliability in distinguishing active from inactive disease. Imaging and procedures such as pulmonary function tests, high-resolution CT, FeNO, echocardiography, and cardiac MRI showed promise but lacked validation. No robust tool currently exists for EGPA monitoring, even though interesting biomarkers and imaging techniques warrant further validation. Future research should prioritise harmonising definitions of remission and relapse, distinguishing systemic from organ-specific activity, and integrate clinical, biomarker, and imaging approaches to develop EGPAspecific monitoring strategies.
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2. Serum CXCL13 is not elevated in ocular Behçet's disease: a brief report.
PMID:日期:2026-09-16该文献暂无摘要。
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3. Clinical manifestations, treatment and prognosis analysis of childhood ANCA-associated vasculitis.
3. 儿童ANCA相关性血管炎的临床表现、治疗和预后分析PMID:日期:2026-09-14To analyse the clinical manifestations and treatment of childhood-onset antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and to identify risk factors for progression to end-stage renal disease (ESRD). We retrospectively enrolled patients aged <18 years diagnosed with AAV at the First Affiliated Hospital of Zhengzhou University. Comparative analyses were performed between microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) groups regarding clinical manifestations, laboratory findings, disease activity, treatment regimens, and progression to ESRD. Statistical methods included the t-test, chi-square test, Cox regression analysis, and Kaplan-Meier curves. A total of 29 patients were included, of whom 22 were female and 23 had MPA. The median age at diagnosis was 13.9 years (IQR 12.3-16.5 years), and the median diagnostic interval was 1 month (IQR 0.6-1.5 months). The most common clinical manifestations were renal, respiratory, and musculoskeletal involvement, and the presentations were similar between MPA and GPA. Fifteen patients progressed to ESRD, 12 of whom had ESRD at initial diagnosis. Glucocorticoids served as the mainstay of treatment. At 12 months post-treatment, 12 patients achieved remission, 3 achieved renal remission, 8 remained on dialysis, and 6 underwent renal transplantation. Long-term survival was achieved in most patients, with one death. Multivariate Cox regression analysis identified elevated serum creatinine as an independent risk factor for progression to ESRD. In this cohort, childhood-onset AAV occurred predominantly in females, with MPA as the major subtype and the kidneys being the most frequently involved organ. Glucocorticoids formed the mainstay of treatment. Approximately half of the children achieved remission following treatment. Patients with elevated serum creatinine levels are at higher risk of progressing to ESRD. Most children achieved long-term survival.
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4. Elderly-onset Behçet's disease presenting with uveitis in a 77-year-old woman.
PMID:日期:2026-09-12该文献暂无摘要。
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5. Sex and menopausal status differences in coronary calcification and extra-coronary computed tomography findings in inflammatory arthritis.
PMID:日期:2026-09-12Patients with inflammatory arthritis (IA) have increased cardiovascular risk. Coronary artery calcium (CAC) scoring by computed tomography (CT) detects early coronary disease. While sex and menopause influence CVD risk, their impact on CT findings in IA is unclear. In this study we aimed to describe the extent and distribution of CT-detected cardiovascular abnormalities in IA, including coronary calcification, and potential differences due to sex and menopause. This was a cross-sectional analysis of IA patients aged >40 years without prior CVD. The primary outcome was CAC score by the Agatston method (0, 1-99, ≥100); secondary outcomes included calcified plaque distribution and other CT-detected abnormalities such as aortic enlargement. Multivariable logistic regression assessed associations with post-menopausal status. Among 597 IA patients, 31% were male (mean age 57.3), 14% pre-menopausal female (46.3 years), and 55% post-menopausal female (61.9 years). Spondyloarthropathy was more common in males (70%); RA was more common in females (70%). CAC ≥100 occurred in 28% of males, 20% of post-, and 1.4% of pre-menopausal females (p<0.0001). Post-menopausal females had more aortic calcification (44%), aortic enlargement (23%, all p≤0.001), while males had more left main, circumflex and right coronary calcification (p≤0.001). Post-menopausal females had lower odds of elevated CAC vs. males (OR 0.29, 95% CI 0.17-0.49). Independent predictors of CAC ≥100 included older age, higher CRP, and smoking. Post-menopausal associations with aortic changes were not significant after adjustment. Sex and menopausal status are associated with coronary and extra-coronary CT abnormalities in IA patients. These observations underscore the need to acknowledge and better understand sex-related differences in CVD risk expression, as traditional and disease-related risk factors may not confer equivalent risk in females and males.
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6. Clinical implication and tissue-specific activation of the OX40-OX40L costimulatory pathway in Sjögren's disease.
PMID:日期:2026-09-07Sjögren's disease (SjD) is a chronic autoimmune disease characterised by immune-mediated inflammation of exocrine glands. The OX40-OX40 ligand (OX40L) costimulatory pathway plays a key role in T cell activation and persistence. However, its involvement in both systemic and tissue compartments in SjD remains incompletely understood. This study investigated the expression of the OX40-OX40L pathway in SjD and its association with clinical and immunologic features. Serum levels of OX40 and OX40L were measured in SjD patients using enzyme-linked immunosorbent assay and compared with those in healthy controls (HCs). Associations with clinical and laboratory parameters, including disease activity indices, were analysed. Expression and spatial localisation of OX40 and OX40L in minor salivary gland biopsy specimens were assessed using immunohistochemistry and immunofluorescence. Serum OX40 levels were significantly elevated in SjD patients compared with HCs and were positively correlated with systemic disease activity and serum β2-microglobulin levels. Higher serum OX40 levels were observed in SjD patients with leukopenia and lymphadenopathy. In minor salivary gland tissue, both OX40 and OX40L expression increased with higher focus scores. OX40 was localised to CD4+ and CD8+ T cells, whereas OX40L was localised to glandular epithelial cells and infiltrating B cells. The OX40-OX40L pathway shows distinct patterns of activation in systemic and glandular immune compartments in SjD. These findings suggest its involvement in disease-related immune responses and support its relevance as a pathway of interest in SjD.
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7. Cardiac involvement in Behçet's disease: a comprehensive state-of-the-art review.
PMID:日期:2026-09-04Behçet's disease (BD) is a chronic multisystemic inflammatory vasculitis which can cause cardiac involvement in less than 6%. It can affect all cardiac wall giving rise to pericarditis, myocarditis, endocardial lesions with valvular involvement (especially aortic insufficiency), intracardiac thrombosis, coronary arteritis, myocardial infarcts, arrythmia, and aortitis. Clinical presentation can be confusing, silent, or overshadowed, so diagnosis is frequently delayed. Early diagnosis is mandatory and different imaging techniques play a pivotal role to screen the heart. Biological agents, including tumour necrosis factor inhibitors, show promising results. Cardiac surgery must be accompanied by immunosuppressive therapy to prevent iatrogenic or trauma-triggered pseudo aneurysm secondary to arterial hypersensitivity. A multidisciplinary approach and tailored monitoring are essential to improve patient outcome. Strong data are still lacking to define evidence-based diagnostic algorithms, risk-stratification tools, and standardised management strategies for this severe cardiac manifestation. Besides, further studies are needed to determine specific biomarkers to refine early diagnosis, assess therapeutic efficiency, and prognosis. Through a comprehensive literature review, we aim to synthesise current data on the epidemiology, clinical presentation, contemporary imaging modalities, prognosis, and evidence‑based management strategies of cardiac involvement in BD, and to highlight emerging perspectives.
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8. Predictors of early severe respiratory distress in ANCA-associated vasculitis with diffuse alveolar haemorrhage: a multicentre REVEAL cohort study.
8. ANCA相关性血管炎伴弥漫性肺泡出血中早期严重呼吸窘迫的预测因素：一项多中心REVEAL队列研究PMID:日期:2026-09-04Diffuse alveolar haemorrhage (DAH) is a life-threatening complication of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). This study aimed to clarify the incidence, timing, and predictors of severe respiratory distress (SRD) in patients with AAV-related DAH. This multicentre retrospective study included 50 consecutive patients with AAV-related DAH enrolled in the multicentre REVEAL cohort. Baseline demographic characteristics, laboratory parameters, and respiratory indices were recorded. The primary outcome was the development of SRD, defined as respiratory failure requiring ventilatory support (high-flow oxygen therapy, non-invasive ventilation, or invasive mechanical ventilation) or DAH-related death within 30 days. Cox proportional hazards models were used to identify independent predictors. SRD occurred in 14 patients (28%), typically within several days of immunosuppressive therapy initiation, and was associated with early mortality. Patients who developed SRD exhibited significantly higher baseline neutrophil counts, lower haemoglobin levels, higher C-reactive protein concentrations, and impaired oxygenation (lower PaO2/FiO2 ratio). Multivariate analysis identified the peripheral neutrophil count as an independent predictor of SRD. A cut-off of 8,800/μL effectively discriminated between high- and low-risk patients. Notably, neutrophilia was associated with early progression to SRD, highlighting its potential as an early indicator of fulminant disease progression. This multicentre study highlights the peripheral neutrophil count as a simple and readily available biomarker for risk stratification in AAV-DAH. Recognising neutrophilia at diagnosis may facilitate closer monitoring, early escalation of supportive care, and timely adjustment to immunosuppressive therapy. These findings provide a rationale for integrating neutrophil count into the prognostic assessment and therapeutic decision-making for AAV-related DAH.