Dermatologie皮肤病学
Dermatologie(英文缩写 DERMATOLOGIE),ISSN 2731-7005,eISSN 2731-7013,中文译名:皮肤病学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2022 | 0.800 | Q4 |
| 2023 | 0.800 | Q4 |
| 2024 | 0.700 | Q4 |
| 2025 | 0.600 | Q4 |
Dermatologie 最新收录文献
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1. [Vulvar intraepithelial neoplasia and vulvar cancer].
PMID:日期:2026-09-22Vulvar intraepithelial neoplasia (VIN) is divided into human papillomavirus (HPV)-associated lesions (undifferentiated VIN, high-grade squamous intraepithelial lesion) and HPV-independent VIN (predominantly differentiated VIN). This new WHO classification is essential for the diagnostics, treatment and prognosis. While 90% of cases seen in practice are high-grade intraepithelial lesions (HSIL), dVIN cases are less common (10%), more difficult to diagnose and carry a higher risk of progression to cancer. The lichen sclerosus that most often underlies these lesions is responsible for these characteristics. The distinction between the two lesions is made using p53 and p16 immunohistochemistry on biopsy/excision specimens. Analogous to VIN, invasive carcinomas are also divided into HPV-associated and HPV-independent tumors. Here too, HPV-independent changes are associated with a worse prognosis. The treatment of dVIN is surgical, while treatment of uVIN can be ablative, surgical or medicinal (imiquimod being preferred). The recurrence rate is high regardless of the treatment chosen. Lifelong follow-up is therefore essential. In the case of an invasive carcinoma the majority of patients can be curatively treated with surgery alone. In cases of lymphatic metastasis, adjuvant chemo(radio)therapy is generally administered; in very advanced disease, particularly when continence function is threatened, primary chemoradiotherapy can also be used. Primary prevention of HPV-induced lesions is highly effective through primary HPV vaccination. Secondary prevention of dVIN/HPV-independent invasive carcinoma appears to be achievable through consistent maintenance therapy of the underlying lichen sclerosus with highly potent topical corticosteroids.
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2. [New treatment options for autoimmune bullous diseases].
PMID:日期:2026-09-22Autoimmune bullous diseases are a heterogeneous group of diseases characterized by autoantibody deposits leading to split formation in the skin and mucous membranes; they are associated with a significant impairment of quality of life and increased mortality. Therapeutic options are limited and rely on broad immunosuppression, primarily the administration of topical or systemic glucocorticosteroids. Rituximab is also approved for moderate to severe pemphigus vulgaris. Due to the rarity of these conditions, the body of clinical research on pemphigus and pemphigoid diseases is limited. Current therapeutic approaches focus primarily on enhancing the efficacy of B‑cell depletion in pemphigus vulgaris/foliaceus, as well as on blocking specific inflammatory mediators in bullous pemphigoid. Further efforts are required to conduct more studies within this group of diseases and to fully realize the potential of more effective drugs with improved side-effect profiles.
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3. [Update on anal dysplasia and anal cancer].
PMID:日期:2026-09-18Anal dysplasia and anal cancers are predominantly caused by high-risk types of the human papillomavirus. Lesions are mostly asymptomatic and disproportionately affect high-risk populations such as people living with HIV, women with a history of vulvar (pre)cancer, and long-term immunosuppressed individuals. For these risk groups, the incidence of anal cancer is up to 100 times higher, which is why screening is recommended in the S2k guideline completed in 2024. However, it should be noted that two-thirds of anal cancers occur in older women without HIV, for whom scalable screening strategies do not yet exist due to a lack of feasible triaging methods. The ANCHOR study provided crucial evidence that timely diagnosis and treatment of high-grade anal dysplasia can significantly reduce the risk of anal cancer. To diagnose anal dysplasia, the German-Austrian guidelines recommend a two-stage process: after initial triaging using medical history, cytology, and HPV typing, high-resolution anoscopy (HRA) with biopsy represents the gold standard for diagnosis. Therapeutically, destructive methods (such as electrocautery or trichloroacetic acid) and local immunomodulatory therapies (imiquimod) are used. Cure rates after a single treatment session are relatively low at 10-30%; multiple treatment cycles are often necessary to clear high-grade anal dysplasia. Combining different therapeutic modalities is frequently a feasible strategy. For advanced anal cancer, recent studies such as POD1UM-303/InterAACT‑2 (immunotherapy with retifanlimab), as well as procedures like plasma HPV-ctDNA measurement (liquid biopsy) and dose-escalated/sparing radiation therapy, show promising results and give a perspective for the ongoing revision of the S3 guideline on anal cancer.
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4. [Focal epithelial hyperplasia-Heck's disease].
PMID:日期:2026-09-17Focal epithelial hyperplasia (FEH), also known as Heck's disease, is a rare, benign condition of the oral mucosa. It is characterized by multiple, soft, skin-colored or whitish papules or flat nodules that occur primarily on the mucosa of the lips, cheeks, and tongue. The prevalence of this condition is particularly high among indigenous populations of Central and South America, leading to some discussion of a genetic predisposition in addition to familial transmission. However, the number of reported cases from all parts of the world is currently increasing, particularly from Europe. FEH occurs primarily in children and adolescents, but older adults are also affected. Infection with human papillomavirus (HPV) types HPV13 or HPV32 has been identified as the cause of FEH. A definitive diagnosis of Heck's disease based on clinical presentation, histology, and HPV genotyping, as well as the differential diagnosis to rule out other oral manifestations allow for a conservative treatment approach, as the causative HPV types do not have oncogenic potential and the lesions often resolve spontaneously.
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7. [Vaccine prevention of HPV-associated diseases].
PMID:日期:2026-09-11Early prophylactic human papillomavirus (HPV) vaccination of girls and boys leads to long-lasting sterile immunity against the HPV types covered by the respective vaccine. Both in clinical trials and in population-based studies, virus-like particle (VLP)-based HPV vaccines have exceeded all expectations regarding immunogenicity and efficacy. In clinical trials, HPV vaccines induced protection rates of 95-100% against high-grade cervical intraepithelial neoplasia (CIN) caused by vaccine-covered types, and nearly 100% against HPV6/11-induced anogenital warts. Numerous studies have demonstrated that early age at vaccination is crucial for the effectiveness of HPV vaccination. The duration of vaccine-induced protection against high-grade CIN and cervical cancer, as documented by long-term studies, currently ranges between 15 and 18 years. In addition to cervical cancer and anogenital warts, early HPV vaccination can also prevent precursor lesions of anal cancer as well as vulvovaginal precancerous lesions at the population level. Several countries have already introduced a single-dose vaccination schedule in line with the WHO recommendation. Given the lack of long-term data and data on HPV infections outside the cervix, Germany and other countries are still maintaining a 2-dose vaccination schedule. The WHO aims to eliminate cervical cancer. To this end, all countries should achieve HPV vaccination rates of 90% among 15-year-old girls by 2030. Due to herd effects, vaccination rates of around 80% may also be sufficient. In Germany, currently only 55% of 15-year-old girls and 36% of boys have completed the full HPV vaccination series. To increase HPV vaccination rates, a national HPV vaccination year is planned to be held in Germany in 2028.
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8. [Wound care following dermatologic surgical procedures].
PMID:日期:2026-09-01Postoperative wound care is an essential component of dermatologic surgical procedures and has a significant impact on wound healing as well as esthetic and functional outcomes. In clinical practice, considerable differences exist with regard to the antiseptics used, dressing materials, and follow-up care concepts. Robust data on current postoperative wound care practices in dermatologic surgery in Germany are limited. The aim of this study was to assess current postoperative wound care practices among skin surgeons in Germany and to compare them with evidence-based recommendations. An anonymous, internet-based survey comprising 26 questions on postoperative wound care was conducted. The questionnaire was distributed to all members of the German Society for Dermatologic Surgery and was additionally offered during the 2025 annual meeting. Data were analyzed descriptively. A total of 62 fully completed questionnaires were analyzed. Octenidine-containing or alcohol-based antiseptics were predominantly used both preoperatively and during dressing changes. Postoperative wound care following primary wound closure was largely homogeneous, whereas a high variability in dressing materials was observed for wounds healing by secondary intention. Topical antibiotics continued to be used to a significant extent despite the risk of developing resistance. The results demonstrate substantial heterogeneity in postoperative wound care and only partial implementation of evidence-based recommendations. In particular, the routine use of topical antibiotics and antiseptics in noninfected wounds appears questionable.
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9. [2 % Simvastatin/2 % cholesterol cream in disseminated superficial actinic porokeratosis effectively and safely used long-term : Case report and retrospective survey of 14 patients].
PMID:日期:2026-09-01Disseminated superficial actinic porokeratosis (DSAP) is a rare, UV-associated keratinization disorder that causes significant cosmetic impairment. In recent years, a new pathogenesis-based therapeutic approach using topical formulations containing statins and cholesterol has been introduced. We report on a 56-year-old woman who had DSAP on both forearms and lower legs for 6 years. Clinically, she presented with multiple, extensor-surfaced, pale erythematous, flat plaques with collarette-like scaling. Previous treatments with topical tretinoin and photodynamic therapy had not resulted in any significant improvement. After 4 months of treatment with a 2% simvastatin/2% cholesterol cream (SC cream) applied twice daily, the lesions had nearly completely resolved. The findings improved on the Investigator Global Assessment (IGA) scale from 3/5 to 1/5. Over a 15-month follow-up period, the improvement remained stable with continued therapy. The patient did not experience any side effects. The favorable clinical course prompted a retrospective evaluation of all DSAP patients treated with SC cream at our institution. A total of 14 patients were surveyed using questionnaires regarding efficacy, tolerability, and satisfaction. The mean duration of treatment was 9 months; 12 patients were treated for at least 6 months, and 5 patients for at least 12 months. With the exception of 1 patient, all reported clinical improvement. The average subjective improvement was over 50% after 6 months and approximately 70% after 12 months. No loss of efficacy was observed. One patient developed mild, self-limiting contact dermatitis without discontinuing therapy. Laboratory tests in 6 patients revealed no clinically relevant abnormalities. Our observations support the sustained efficacy and good tolerability of the SC cream during prolonged use. At the same time, potential contact dermatitis should be considered as a relevant adverse drug reaction. These observations are consistent with the recently published results of the Mainz working group led by Prof. Staubach-Renz, which are also discussed in our article.
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10. [Masquerade syndrome-an interdisciplinary challenge].
PMID:日期:2026-09-01The masquerade syndrome is a differential diagnostic concept in which neoplastic, and less commonly nonneoplastic, diseases imitate periocular or intraocular inflammatory conditions, thereby masking the underlying pathology. This often results in delayed diagnosis of the underlying disease. An 85-year-old patient presented with intermediate uveitis and visual impairment. Further diagnostic evaluation revealed an axillary lymph node metastasis from a malignant melanoma that had been excised more than 20 years earlier. This case illustrates that inflammatory ocular symptoms in patients with malignant melanoma can be paraneoplastic and may indicate tumor recurrence or progression.