Journal of Cardiovascular Development and Disease心血管发育与疾病杂志
Journal of Cardiovascular Development and Disease(英文缩写 J CARDIOVASC DEV DIS),ISSN 2308-3425,eISSN 2308-3425,中文译名:心血管发育与疾病杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
Journal of Cardiovascular Development and Disease 最新收录文献
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1. Balloon Angioplasty for Recoarctation in Infants with Isolated Aortic Coarctation and Coarctation Associated with Other Congenital Heart Diseases.
PMID:日期:2026-09-20For infants who underwent surgical coarctation repair and required balloon angioplasty for recoarctation within the first year of life, data are limited-especially regarding safety, mid-term efficacy, and reintervention risk factors. This retrospective study included the data of 33 infants who underwent surgical correction of CoA within their first three months of life and whose first cardiac catheterization for recoarctation-defined by a systolic echocardiographic gradient of ≥20 mmHg-was performed within the first year of life. The median age at repair was 21 days, and that at angioplasty was 77 days. The peak systolic gradient decreased from 40.0 to 21.0 mmHg ( < 0.001), and the mean gradient decreased from 13.9 to 6.7 mmHg ( = 0.02). The aortic stenotic diameter increased from 3.2 to 4.1 mm ( < 0.001), and the z score increased from -4.2 to -2.7 ( < 0.001). Right arm systolic blood pressure dropped from 111.8 to 88.2 mmHg ( < 0.001); 7% of cases remained hypertensive. Complications occurred in 12% of patients, and reintervention was needed in 39.4%. Association with other congenital heart disease increased reintervention risk (OR 4.51). Follow-up gradients were as follows: 27.4 ± 10.2 mmHg (1 year), 24.6 ± 8.3 mmHg (2 years), 32.8 ± 18.8 mmHg (5 years), and 35.4 ± 23.2 mmHg (7 years). Early balloon angioplasty for postoperative recoarctation is safe, effective, and repeatable, with a high procedural success rate and sustained hemodynamic improvements. Reinterventions were more common in patients with additional CHD, though outcomes remained favorable.
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2. Cell-Surface Signatures and Targets of Modulated Vascular Smooth Muscle Cells in Atherosclerosis: From State Identification to Precision Intervention.
PMID:日期:2026-09-20Atherosclerotic plaques contain vascular smooth muscle cell (VSMC)-derived populations that no longer fit a simple contractile-versus-synthetic model. Lineage tracing, single-cell transcriptomics, spatial profiling and multimodal surface-protein measurements now show that VSMC-derived cells occupy heterogeneous lesional states with pathogenic, reversible or plaque-stabilizing properties. This diversity creates a translational bottleneck. Intracellular markers and transcriptomic clusters can define state transitions, but they do not by themselves provide handles for live-cell isolation, molecular imaging, targeted delivery or selective intervention. This narrative review examines how VSMC state discovery can be translated into cell-surface signatures and surface-accessible intervention interfaces. We distinguish state/lineage markers, surface identification and sorting signatures, functional surface interfaces, causally supported candidate targets, and intervention-supported surface targets. Current evidence positions CD29, CD90, CD142, and CD200 primarily as tools for live-cell identification, whereas fibroblast activation protein (FAP) represents the most advanced example of an intervention-supported surface target for the depletion of a disease-associated modulated VSMC state. We propose a state-matched framework in which pathogenic states are selectively depleted, plastic or reversible states are modulated or reprogrammed, and matrix-supportive plaque-stabilizing states are preserved. C-C chemokine receptor type 2 (CCR2), guanylyl cyclase-B/natriuretic peptide receptor 2 (GC-B/NPR2), matrix metalloproteinase 14 (S14), and CD47 span different intermediate levels of therapeutic evidence, from targeted delivery to functional surface modulation and causal intervention, whereas CD36, triggering receptor expressed on myeloid cells 2 (TREM2), and integrins remain constrained by incomplete cell-state or lineage specificity. Major barriers include human protein-level and surface validation, state specificity, spatial accessibility and direct therapeutic testing.
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3. Age-Dependent Efficacy of Incidental Coronary Artery Calcium on Pre-CAG Chest CT: Potentially Missed Prevention Opportunities in Chinese Population.
PMID:日期:2026-09-20The 2026 ACC/AHA Multisociety Dyslipidemia Management Guideline emphasizes the clinical utility of coronary artery calcium (CAC) and recommends integrating incidental CAC from non-ECG-gated chest CT into cardiovascular risk-stratification workflows; nevertheless, such incidental findings remain substantially underutilized in routine clinical practice. Many young-to-middle-aged patients present with acute myocardial infarction as their index cardiovascular event, even though prior chest CT could identify CAC that would trigger statin-based primary prevention. This single-center retrospective observational study enrolled 976 patients undergoing invasive coronary angiography (CAG) who had non-ECG-gated chest CT within the preceding 1 year (2020-2025) to assess cross-sectional associations between incidental CAC burden and angiographic coronary stenosis. CAC burden was categorized as Grade 0-3 using the validated Shemesh ordinal scoring system, with 79.2% of participants being CAC-positive. CAC positivity and obstructive CAD prevalence increased progressively with age. CAC positivity was associated with higher conditional odds of obstructive CAD among younger individuals, while this conditional risk signal was attenuated in older adults. CAC grade showed a step-wise positive correlation with stenosis severity. Following adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, and smoking status, CAC was identified by multivariate regression as the strongest independent predictor of obstructive CAD (OR = 11.732, 95% CI: 7.700-17.875, < 0.001). Among CAD patients, CAC-negative subjects had higher diabetes prevalence, in keeping with the propensity for non-calcified vulnerable plaques in diabetic individuals. Incidental CAC on routine chest CT represents a robust age-modulated biomarker for obstructive CAD, and considerable primary-prevention opportunities are missed in Chinese patients referred for CAG. Opportunistic age-stratified CAC screening assisted by artificial intelligence may improve real-world cardiovascular primary prevention.
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4. Assessing the Correlation Between Inter-Leg Ankle-Brachial Index Asymmetry and Peripheral Artery Disease Outcomes.
PMID:日期:2026-09-17Peripheral artery disease (PAD) remains underdiagnosed and suboptimally treated, with limited disease awareness and underutilization of available diagnostic strategies representing important contributing factors. The ankle-brachial index (ABI) is the gold-standard screening test for PAD and has been shown to correlate with limb outcomes. However, the current interpretation of ABIs does not account for clinically significant differences between legs, which may reflect asymmetric disease burden and have an impact on limb outcomes. The association between inter-leg ABI asymmetry and PAD outcomes is unclear and requires further study. Thus, we assessed the prognostic importance of a clinically significant difference in left and right ABI values (≥0.15) on limb outcomes in patients with PAD. A total of 3313 patients with PAD who received outpatient vascular care at a single institution were retrospectively analyzed. At baseline, ABIs were measured in a certified vascular laboratory by dividing the higher of the dorsalis pedis or posterior tibial artery systolic pressures in each leg by the higher brachial systolic pressure. Inter-leg ABI asymmetry was defined by an absolute difference between left and right ABI values ≥ 0.15, which has been shown to be clinically significant. The primary outcome was major adverse limb event (MALE) over 2 years of follow-up. MALE was defined as the need for vascular intervention (either open or endovascular lower extremity revascularization) or major lower extremity amputation above the ankle. The association between inter-leg ABI asymmetry and 2-year MALE was evaluated using univariable and multivariable logistic regression models adjusted for age, sex, body mass index (BMI), and ABI-defined hemodynamic severity. The mean participant age was 58.4 years (SD 12.9), 966 (29.2%) participants were female, and the mean BMI was 28.8 kg/m (SD 5.7). There were 666 (20.1%) patients who had inter-leg ABI asymmetry. The mean inter-leg ABI difference was 0.38 (SD 0.29) in the inter-leg ABI asymmetry group and 0.04 (SD 0.02) in the no inter-leg ABI asymmetry group ( < 0.001). Patients with inter-leg ABI asymmetry were more likely to have moderate PAD (36.0% vs. 6.5%, < 0.001) and severe PAD (6.2% vs. 0.7%, < 0.001), and less likely to have mild PAD (57.8% vs. 92.8%, < 0.001), compared to patients with no inter-leg ABI asymmetry. Over the median follow-up period of 2 years, 304 (9.2%) participants experienced MALE. The 2-year MALE rate was significantly higher in patients with inter-leg ABI asymmetry compared to those without (26.0% vs. 4.9%, < 0.001). Similarly, patients with inter-leg ABI asymmetry had a higher rate of the need for revascularization (21.5% vs. 4.1%, < 0.001) and major amputation (10.2% vs. 1.8%, < 0.001). Multivariable logistic regression controlling for age, sex, BMI, and ABI-defined hemodynamic severity showed that inter-leg ABI asymmetry was independently associated with 2-year MALE (adjusted OR 3.70, 95% CI 2.80-4.91, < 0.001). In this study, over 20% of patients with PAD had clinically significant inter-leg ABI asymmetry, which was independently associated with a nearly four times higher odds of 2-year MALE, including the need for revascularization and major amputation. Our results suggest that inter-leg ABI asymmetry may represent a readily available prognostic marker of adverse limb outcomes in patients with PAD. Further external validation and prospective studies are needed to determine whether incorporating inter-leg ABI asymmetry into clinical assessment improves risk stratification or clinical outcomes.
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5. Beyond Traditional Risk Scores: Artificial Intelligence in Coronary Plaque Characterization and Personalized Atherosclerosis Management.
PMID:日期:2026-09-16Atherosclerosis remains a leading global cause of cardiovascular morbidity and mortality, yet its insidious progression and multifaceted etiology, spanning genetic, metabolic, and environmental determinants, often delay clinical recognition until adverse events occur. Traditional risk stratification tools, while foundational in preventive cardiology, are constrained by their reliance on limited variables and static linear assumptions, frequently misclassifying individuals at the extremes of risk. This review critically examines the transformative role of artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), in redefining atherosclerosis management across three interconnected domains. First, we explore how AI-driven predictive models integrate high-dimensional data, from genomics and imaging to real-time wearable metrics, to achieve superior cardiovascular risk stratification compared with conventional scores. Second, we detail AI's capacity to automate and enhance plaque characterization through advanced imaging analysis, enabling reproducible quantification of burden, composition, and vulnerability markers that are imperceptible to human readers. Third, we investigate AI-powered clinical decision support systems, digital twins, and reinforcement learning approaches that facilitate dynamic, personalized treatment planning tailored to each patient's evolving profile. We also critically address the ethical imperatives, algorithmic fairness, data privacy, transparency, and accountability, alongside practical challenges of clinical integration, regulatory validation, and health equity.
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6. The Management of Left Subclavian Artery in Aortic Open and Endovascular Surgery.
PMID:日期:2026-09-16Management of the left subclavian artery (LSA) during aortic arch surgery is complex due to its deep anatomical location and potential pathological alterations, posing risks such as stroke, spinal cord injury, and recurrent laryngeal nerve damage. Revascularization of the LSA is critical in various clinical scenarios to maintain adequate perfusion to the vertebral arteries, spinal cord, and upper limb, especially in patients with anatomical variations, prior bypass surgeries, or increased risk of ischemia. Coverage of the LSA during thoracic endovascular repair (TEVAR) without revascularization significantly increases stroke and spinal cord ischemia rates. We provided a narrative review, evaluating contemporary open and endovascular options for the treatment of the aortic arch, and consequently of the LSA. Frozen elephant trunk (FET), endovascular strategies (branched and fenestrated TEVAR), but also emerging hybrid devices, are all valuable treatments with respective strengths and limitations to be understood to obtain the best patient-prosthesis match. Individualized treatment selection based on pathology, urgency, and patient factors is essential to optimize outcomes. This evolving paradigm integrates open and endovascular techniques to enhance patient care in complex aortic arch disease.
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7. Association Between Self-Reported Weekly Physical Activity Duration and Echocardiographic Cardiac Structure and Function in Adults Aged ≥ 45 Years: A Cross-Sectional Study.
PMID:日期:2026-09-16The association between habitual physical activity duration and cardiac structure and diastolic function remains incompletely characterized. To evaluate the relationship between self-reported weekly physical activity duration and echocardiographic parameters in adults aged ≥ 45 years. This exploratory cross-sectional study included 84 adults recruited from a cardiology outpatient clinic and classified into three groups according to weekly physical activity duration: <4 h/week (Group A, = 32), 4-12 h/week (Group B, = 28), and >12 h/week (Group C, = 24). All participants underwent transthoracic echocardiography. Multivariable analyses were adjusted for age, sex, body mass index, systolic blood pressure, arterial hypertension, type 2 diabetes mellitus, and smoking. Exploratory natural cubic spline analyses evaluated physical activity as a continuous exposure. Participants reporting 4-12 h/week generally showed the most favorable echocardiographic profile. Significant between-group differences after false discovery rate correction were observed for several indices of cardiac remodeling and diastolic function. The proportions of participants classified as having left ventricular diastolic dysfunction according to the original clinical echocardiographic assessment were 37.5%, 32.1%, and 75.0% in Groups A, B, and C, respectively ( = 0.004; q = 0.006). After adjustment, Group C had higher odds of being classified as having diastolic dysfunction than Group B (OR = 8.246; 95% CI: 2.118-32.096; = 0.002). Spline analyses demonstrated significant non-linear associations for LVMI, RWT, mean E/e', and lateral e' velocity. Weekly physical activity duration was associated with cardiac remodeling and diastolic function. Intermediate activity duration was associated with a more favorable echocardiographic profile; however, these exploratory findings do not establish an optimal exercise dose or harmful effects of higher activity.
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8. Thiol-Disulfide Homeostasis and Erythrocyte Glutathione Balance in ST-Elevation Myocardial Infarction: A Prospective Case-Control Study.
PMID:日期:2026-09-16: ST-elevation myocardial infarction (STEMI) provokes intense oxidative stress. Serum thiol-disulfide and intracellular glutathione balances reflect oxidative status in different compartments and are rarely measured together. We compared both axes between patients with STEMI and chest-pain controls without chronic disease and examined their relation to infarct severity. : In this prospective single-center case-control study, both axes were measured with automated assays in 90 patients with STEMI and 79 controls. Blood was drawn at first contact, before any drug and before reperfusion. Groups were compared with Welch t or Mann-Whitney U tests, with effect sizes, 95% CIs, and Benjamini-Hochberg correction. : All 10 markers differed between groups (adjusted < 0.001). Patients had lower native thiol (315.0 (69.6) vs. 407.4 (63.3) µmol/L; Hedges' = -1.38) and higher disulfide (22.4 (6.8) vs. 16.9 (6.4) µmol/L; = 0.82). Reduced glutathione was lower (733.2 (87.9) vs. 869.8 (83.7) µmol/L; = -1.58) and oxidized glutathione higher, raising the GSSG/GSH ratio (median 0.074 vs. 0.030; = 0.72). Differences persisted after adjustment for age and sex and within each sex. Within STEMI, marker-severity correlations were weak, and none survived correction. : Both redox systems shift toward oxidation in STEMI. These markers were not graded indices of infarct severity, and no diagnostic or prognostic use is claimed.
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9. Clinical Management Across CAD-RADS Categories in Patients with Intermediate CT-FFR.
PMID:日期:2026-09-15Interpretation of intermediate computed tomography-derived fractional flow reserve (CT-FFR) remains uncertain. We evaluated whether Coronary Artery Disease Reporting and Data System (CAD-RADS) severity modifies the association between CT-FFR and downstream management in patients with CT-FFR 0.71-0.80. This retrospective study included 973 symptomatic patients stratified by index-vessel CAD-RADS category and CT-FFR 0.71-0.75 versus 0.76-0.80. Planned revascularization within 90 days was the primary outcome. Multivariable logistic regression assessed CT-FFR associations and interaction with CAD-RADS; major adverse cardiac and cerebrovascular events (MACCE) were exploratory. Planned revascularization occurred in 39.8% versus 19.3% of patients with CT-FFR 0.71-0.75 versus 0.76-0.80 (adjusted odds ratio [OR], 2.38; 95% confidence interval [CI], 1.72-3.29; < 0.001). Each 0.01 decrease in CT-FFR was associated with higher odds of revascularization (adjusted OR, 1.23; 95% CI, 1.15-1.32; < 0.001). The association differed by CAD-RADS category (interaction = 0.011), with a more pronounced association observed in CAD-RADS 3 (adjusted OR per 0.01 decrease, 1.39; 95% CI, 1.25-1.54). During a median follow-up of 384 days, 31 patients (3.2%) experienced MACCE, with no significant adjusted association with CT-FFR. Among patients with intermediate CT-FFR, lower values were associated with a higher likelihood of planned revascularization, and the magnitude of this association differed across CAD-RADS categories.
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10. Association Between Prognostic Nutritional Index and Clinical Outcomes After Percutaneous Coronary Intervention in Elderly Patients with Chronic Total Occlusion.
PMID:日期:2026-09-14This study aimed to investigate the association between the prognostic nutritional index (PNI) and long-term all-cause mortality and major adverse cardiovascular events (MACEs) in elderly patients with chronic total occlusion (CTO) after successful percutaneous coronary intervention (PCI). This retrospective study enrolled 745 consecutive patients aged ≥ 60 years with successfully revascularized CTO between February 2011 and April 2023. All-cause mortality was the primary endpoint. MACE, defined as the first occurrence of all-cause mortality, non-fatal myocardial infarction, stroke, or target-vessel revascularization (TVR), was the secondary endpoint. Cox proportional hazards models and restricted cubic spline (RCS) analyses were used to evaluate associations. During a median follow-up of 813 days, 58 (7.8%) all-cause mortality and 101 (13.6%) MACE occurred. In the primary multivariable model (Model 2), each 1-unit increase in PNI was associated with a 15% reduced risk of all-cause mortality (HR 0.85, 95% CI 0.81-0.90; < 0.001) and an 8% reduced risk of MACE (HR 0.92, 95% CI 0.88-0.96; < 0.001). Compared with the T1 group, patients in the T2 group had a significantly lower risk of all-cause mortality (HR = 0.21, 95% CI: 0.10-0.44; < 0.001) and MACE (HR = 0.38, 95% CI: 0.23-0.63; = 0.002). Similarly, the T3 group showed a significantly lower risk of all-cause mortality (HR = 0.24, 95% CI: 0.11-0.52; = 0.003) and MACE (HR = 0.49, 95% CI: 0.30-0.82; = 0.007). These associations remained directionally consistent in exploratory models with more extensive covariate adjustment. RCS indicated a linear association between PNI and all-cause mortality ( = 0.959) and a nonlinear association with MACE ( = 0.017). In this single-center retrospective cohort of elderly patients after successful CTO-PCI, lower baseline PNI was associated with higher risks of all-cause mortality and MACE. PNI may be a useful risk stratification tool, but its clinical utility requires confirmation in prospective, externally validated studies before implementation.