Hormones and Behavior激素与行为
Hormones and Behavior(英文缩写 HORM BEHAV),ISSN 0018-506X,eISSN 1095-6867,中文译名:激素与行为 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.492 | Q2 |
| 2022 | 3.500 | Q1 |
| 2023 | 2.500 | Q2 |
| 2024 | 2.400 | Q2 |
| 2025 | 2.600 | Q2 |
Hormones and Behavior 最新收录文献
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1. Effects of hormonal contraceptives on spatial navigation in gonadally intact female rats.
PMID:日期:2026-09-22Rats can either use place memory, response memory or rely on a single cue to navigate their environment. Which navigation strategy a female rat is biased towards is influenced by circulating levels of ovarian hormones. Hormonal contraceptive use is typically associated with changes in circulating levels of endogenous ovarian hormones. The aim of the current study was to examine the effects of synthetic hormones used in hormonal contraceptives on navigation strategies. A total of 61 gonadally intact female rats were tested in two Morris water maze tasks. Rats were administered ethinyl estradiol (EE; 10 μg/kg; n = 10), levonorgestrel (LNG; 20 μg/kg, n = 10), a combination of both EE and LNG (10 μg/kg and 20 μg/kg, n = 10), or vehicle control (n = 31). Controls were tested during either proestrus (n = 10), estrus (n = 11) or diestrus (n = 10). In the place vs. response task, proestrus females exhibited an initial place memory bias while estrus females exhibited an initial response memory bias (OR = 18). However, all groups, apart from the EE + LNG group, eventually spent more time in the place quadrant (η = 0.53), suggesting a corrective shift towards place memory when unable to locate the platform. In the cue task, all groups, apart from the EE + LNG, showed an initial bias to the other quadrant (η = 0.41). This initial bias was abolished in all groups, apart from proestrus females, by the end of the probe. The EE + LNG group failed to exhibit a bias for any of the navigation strategies throughout, suggesting that this formulation of combined EE + LNG may impede memory bias formation.
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2. How transient experience produces durable commitment: A recursive execution-encoding architecture for filial imprinting.
PMID:日期:2026-09-18Filial imprinting in precocial birds provides an unusually tractable example of how a brief early-life experience becomes a durable behavioral commitment. Decades of work in the domestic chick have identified the intermediate medial mesopallium (IMM), thyroid-hormone-dependent regulation of the sensitive period, rapid kinase and translational signaling, receptor and synaptic remodeling, later transcriptional divergence, and distributed retrieval networks. What remains unresolved is how these events relate across scales. Here the ARCH × Φ framework is extended into a recursively coupled execution-encoding architecture. At the execution layer, orienting and approach require the joint action of neural architecture (A), behavioral drive (D), stimulus context (C), and an immediate permissive state (Φ). At the encoding layer, activity generated by successful execution engages intracellular mechanisms that can reconfigure a multidimensional neural substrate. The resulting substrate change, rather than persistence of the original gate, alters future execution and learning capacity. In the chick, the sensitive-period component of Φ is treated operationally as an effective writability state with experimentally separable control points, including rapid thyroid-hormone signaling, GABAergic balance, and AKT/mTORC1-dependent translational capacity. This formulation explicitly accommodates evidence that the rapid imprinting-permissive action of T3 is non-genomic. Chromatin regulation is retained only as a plausible downstream stabilization mechanism whose direct role in chick IMM remains untested. The account further distinguishes the transient gate from the persistent substrate written while that gate is open, reinterprets priming as persistence of that substrate rather than prolonged T3 signaling, and represents encoding as signed, multidimensional reconfiguration rather than monotonic accumulation. The model generates testable predictions concerning gate control, modality-specific implementation, structural reorganization, cross-scale covariance, and retrieval-network redistribution. Filial imprinting is thereby treated as a special case of a broader biological problem: how transient permissiveness allows experience to rewrite the substrate on which future behavior is executed.
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3. Inspiration from nature: A path from the past to the future of behavioral neuroendocrinology - An essay submitted upon receipt of the Daniel S. Lehrman Lifetime Achievement Award.
PMID:日期:2026-09-17A career in science can follow a linear path or might proceed with many unexpected twists and turns. Junior scientists can be discouraged but, more often than not, talent and perseverance create opportunities that lead to a fulfilling career. Patience also keeps open the door for serendipity. It is also the case that a life of curiosity and experimentation plants many seeds along the way in the form of ideas, unexpected hypothesis-bending data, and supportive collegial relationships. These kernels can germinate quickly, mature slowly over a lifetime or they may lay quiescent only to reappear productively many years later. As an example of these processes in action, in this essay, I describe my career as a lab and field behavioral neuroendocrinologist, the way serendipity steered my path forward and the way early life events sprouted into the sturdy trunks that supported my scientific productivity. This Lifetime Achievement Award is the result of many serendipitous events, and, since most of these involve avian neuroendocrinology, it is highly appropriate that Danny Lehrman's name is also being honored. I am proud to be associated with his life and influence.
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4. Organizational impacts of hypothyroidism on behavior.
PMID:日期:2026-08-28Thyroid hormones regulate embryonic and fetal neurodevelopment, with the maternal thyroid gland exclusively producing these hormones for the first half of gestation and then a combination of maternal and fetal production occurring during the second half of gestation. Hypothyroidism during pregnancy is common in humans, particularly due to the additional demand put on the thyroid gland as pregnancy proceeds. Epidemiological studies have linked maternal hypothyroidism to an increased risk of attention-deficit/hyperactivity disorder and autism spectrum disorder diagnosis in these children, as well as cognitive deficits and delays. Rodent models have been extensively used to model developmental hypothyroidism and study the long-term effects on offspring. Increases in activity, reductions in anxiety, cognitive impairments, and social alterations have been observed. In this review, I discuss the current understanding of the organizational impacts of hypothyroidism on activity, affective behaviors, cognition, and social behaviors in humans and animal models, paying special attention to critical periods that may underlie these effects. I also review potential interactions between thyroid hormones and steroid hormones known to be important for organization of the brain and behavior during perinatal and adolescent development. Understanding the effects of developmental hypothyroidism is critical, as early developmental exposure to many endocrine-disrupting chemicals may alter behavior through reducing thyroid hormone signaling, and the final section of the paper reviews these interactions. Understanding the organizational effects of thyroid hormones is important for decisions related to screening and interventions during pregnancy.
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5. Anterior cingulate cortex, anterior insular cortex and altruistic behaviors; a hypothetical role for oxytocin.
PMID:日期:2026-08-01This paper reviews evidence that neurons in the anterior cingulate cortex (ACC) and anterior insular cortex (AI) are involved in the production of altruistic behaviors. But because so many other cognitive and behavioral functions have been ascribed to ACC and AI, one must ask: how might mechanisms producing altruistic behaviors be distinguished from those for other functions? We hypothesize that oxytocin actions in ACC and AI can provide mechanisms fostering altruistic behaviors. Secondarily, we hypothesize that von Economo neurons participate in oxytocin's support of altruistic behaviors.
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6. Effects of peripubertal onset of hyperandrogenism on sociosexual behavior of mice modeling polyendocrine metabolic ovarian syndrome.
PMID:日期:2026-08-01Sex differences in circulating androgens are well-known to organize and activate neural and behavioral sex differences of traditional animal models, but much less is known about the consequences of intrasexual differences in androgens. One approach to this question is studying the effects of hyperandrogenism in females. Hyperandrogenism is associated with several endocrine conditions affecting women, with polyendocrine metabolic ovarian syndrome (PMOS) being the most common during reproductive years. PMOS symptoms often emerge around puberty, raising the possibility of organizational effects of hyperandrogenism on neurobehavioral phenotype. Using a mouse model of PMOS, we examined how the timing of symptom induction by 5α-dihydrotestosterone (DHT) treatment affects androgen-linked sociosexual behavioral phenotype. Female mice received DHT or vehicle treatment at peripuberty (PND21) and again in adulthood (PND60), generating four treatment groups with distinct developmental treatment histories. Behavioral testing assessed social preference, stereotyped/repetitive behaviors and partnered social interactions following the first and second androgen treatment. Brain FOS following partnered interaction with an age-matched, unfamiliar female was also measured. Peripubertal DHT treatment accelerated pubertal onset, as indicated by earlier vaginal opening and increased body weight. Androgen treatment had no effect on stereotyped/repetitive behavior or FOS expression but peripubertal androgen treatment altered exploratory activity during adult social preference tests, rather than social preference per se. In partnered interaction tests, both peripubertal and adult androgens increased masculine sexual approach responses, including mounting, with minimal effects on social behavior. These results are consistent with other evidence that peripubertal androgenic mechanisms can organize neurobehavioral phenotypes.
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7. Day and night variation of plasma melatonin and glucocorticoids in a subterranean rodent endemic to north-west Argentina in two seasons.
PMID:日期:2026-08-01Tuco-tucos (Ctenomys coludo) are Neotropical rodents that inhabit the extreme photic environment of the subterranean, thus being intriguing models for chronobiological studies of circadian and seasonal rhythms. Here we characterized day/night profiles of plasma melatonin and glucocorticoids along with their activity/rest rhythms from freshly caught animals during two seasons. Animals were live-trapped in their native Monte Desert (Argentina) during summer (n = 27) and winter (n = 18), housed under constant dark conditions with wheel-running activity recording prior to sample collection. Sampling occurred at six timepoints across day and night to obtain cross-sectional data. Unlike typical lab-based seasonal studies using artificial photoperiods, our approach captures the complexity of environmental cycles by studying wild animals exposed to the full array of environmental variations across seasons. Melatonin, cortisol and corticosterone were analyzed via ELISA. Melatonin levels showed circadian rhythmicity with higher levels during subjective night. Results revealed higher levels of cortisol secretion during subjective night, consistent with the profile of a nocturnal-active animal. Cortisol levels were 25 to 50 times higher than corticosterone. These findings provide the first circadian melatonin and glucocorticoid baseline for C. coludo in two seasons paving the way for future work on their endocrine rhythms and interplay with activity/rest rhythms and other circadian patterns.
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8. Regulating intense fear: Does cognitive reappraisal attenuate physiological and subjective fear responses in an immersive VR environment?
PMID:日期:2026-08-01Emotional experience and the regulation thereof are typically studied using picture inventories or short films to induce and modify affective states. These approaches, however, lack ecological validity due to their passive and receptive nature. Recent innovations in virtual reality and mobile neurophysiological technologies have enabled researchers to study the behavioral and neural correlates of more ecologically valid emotional responses. In this preregistered study, 58 healthy participants were randomly assigned to either use cognitive reappraisal (intervention) or to immerse themselves in their senses and surroundings (control) while walking across a wooden plank suspended 80 stories above the ground in virtual reality. We measured subjective fear ratings, salivary alpha amylase and cortisol levels, as well as frontal brain asymmetries, captured using mobile electroencephalography (EEG). Across both conditions, we found decisive evidence of increased subjective fear and salivary alpha amylase, a marker of sympathetic activation. However, we found no increase in cortisol levels following the task suggesting that subjective fear alone is not sufficient to trigger a cortisol response. In contrast to our hypotheses, the reappraisal group did not show any difference compared to the control group for neither emotional, endocrine nor neural measures. On the one hand, our findings may suggest that reappraisal might not be a suitable strategy to regulate realistic and intensely frightening situations. On the other hand, further analyses also indicated that the control group may have also regulated their emotions due to increased mindfulness of their inner states and their environment. Future studies are needed to confirm these observations and ascertain the efficacy of cognitive reappraisal on fear in realistic settings.
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9. Traditional masculinity ideology enhances testosterone reactivity in human fathers of preschoolers.
PMID:日期:2026-08-01The Challenge Hypothesis suggests that decreases in testosterone represents a shift in energetic resources toward more nurturing paternal behavior, and increased testosterone toward competitive mating behavior. More controversial theories have also suggested that elevated testosterone is related to more stereotypically "masculine" behavior. Parenting dynamics are heavily influenced by gender roles, but little research has examined how the proposed roles of testosterone and masculinity might interact in a parenting context. We measured salivary testosterone across 42 father-child interactions and analyzed how the father's traditional masculinity ideology was related to changes in testosterone across the lab visit, hypothesizing that higher traditional masculinity ideology would predict a smaller decrease in testosterone due to notions of caregiving as a traditionally "feminine" responsibility. Contrary to our hypothesis, testosterone declined more in fathers who reported higher alignment with traditionally masculine beliefs, and among those who did not identify as the child's primary caregiver. These findings contradict notions that greater masculinity is related to increased testosterone and suggest that the physiological responses observed during such interactions may be influenced by perceptual factors such as the novelty of the situation.
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10. Sex in experiments: Design considerations, statistical analysis and interpretation.
PMID:日期:2026-08-01The inclusion of both sexes in preclinical research has raised practical questions about variability, statistical power, and required sample size. Much of this uncertainty arises from treating sex as a complication rather than as part of the experimental structure. Here I outline the statistical consequences of incorporating sex into experimental design and analysis. Adding sex converts a two-group comparison into a factorial experiment that simultaneously estimates treatment effects, baseline differences, and sex-dependent responses. This article outlines how experiments including both sexes can be designed, how main effects and interactions should be interpreted, how exploratory and confirmatory aims differ, and how visualization and reporting can prevent common errors. Importantly, powering studies for treatment effects generally requires little increase in animal numbers, whereas detecting interactions represent a distinct and inherently more demanding question.