NATURE REVIEWS MOLECULAR CELL BIOLOGY自然综述·分子细胞生物学
NATURE REVIEWS MOLECULAR CELL BIOLOGY(英文缩写 NAT REV MOL CELL BIO),ISSN 1471-0072,eISSN 1471-0080,中文译名:自然综述·分子细胞生物学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 113.915 | Q1 |
| 2022 | 112.700 | Q1 |
| 2023 | 81.300 | Q1 |
| 2024 | 90.200 | Q1 |
| 2025 | 118.000 | Q1 |
NATURE REVIEWS MOLECULAR CELL BIOLOGY 最新收录文献
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2. Mechanisms and disease relevance of DNA break repair pathway choice.
2. DNA断裂修复途径选择的机制及其与疾病的相关性PMID:日期:2026-09-18Understanding what drives the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) as the DNA double-strand break (DSB) repair pathway can help to elucidate mechanisms of genome repair and acquired drug resistance in cancer cells. This choice is intimately linked with a highly regulated process of DNA end resection, mediated by several nuclease entities. Concerted efforts by many laboratories have identified several factors involved in DNA end resection, but we are only beginning to appreciate the mechanisms that underpin DSB repair pathway choice. In this Review, we highlight how DSB repair factors, DSB repair regulators and chromatin modifications determine whether HR or NHEJ is engaged as the repair pathway, with a focus on the antagonistic roles of the tumour suppressor complex BRCA1-BARD1 and the 53BP1 axis in repair pathway choice. How RNA-DNA hybrids affect HR execution and how they are processed by helicases and HR factors is also discussed. Moreover, we describe how dysfunction in repair pathway choice affects tumorigenesis and drives chemotherapeutic resistance.
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3. A practical guide to studying genome function using single-molecule genomics.
3. 研究基因组功能的实用指南：基于单分子基因组学方法PMID:日期:2026-09-14Single-molecule genomics (SMG) has transformed our ability to study the mechanisms that regulate the genome by enabling profiling of the activity of regulatory factors on individual DNA molecules genome-wide. SMG is able to quantify molecular heterogeneity and the co-occurrence of regulatory events, including epigenetic modifications, transcription factor binding and chromatin organization on single DNA molecules. SMG reveals dynamics of chromatin interactions that cannot be measured by conventional genomics assays. Therefore, SMG offers a unique platform to study how regulatory events combine to control genome activity. In this Expert Recommendation article, we provide a practical guide for adopting SMG and outline best practices.
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4. PRC2-RNA interactions through the lens of bioinformatics pipeline choices.
4. 从生物信息学流程选择的角度看PRC2-RNA相互作用PMID:日期:2026-09-11该文献暂无摘要。
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5. Author Correction: Mechanisms and regulation of the Hsp70 chaperone network.
5. 作者更正：Hsp70 chaperone网络机制与调控PMID:日期:2026-09-09该文献暂无摘要。
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8. Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease.
PMID:日期:2026-08-27Microtubules are well-researched components of the cytoskeleton, yet we lack a holistic understanding that bridges molecular and cellular details with the broader functions of the microtubule cytoskeleton in development, ageing and disease. For example, how microtubule properties and functions are affected by tubulin post-translational modifications, disease-related mutations or variation of the microtubule lattice remains unexplored. In this Roadmap, we argue that integrating various experimental and theoretical approaches to bridge different spatial and temporal scales will offer new opportunities for gaining insights into essential cellular mechanisms and physiology, eventually revealing how microtubule dysfunction can lead to a broad spectrum of human diseases. Built on the current state of the art in the microtubule field, our Roadmap highlights future opportunities and challenges and proposes ways to tackle them. Given the many fundamental questions remaining to be answered, the microtubule cytoskeleton will continue to inspire scientists as it has been doing for decades.
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9. Mechanisms and balanced regulation of plant immunity.
PMID:日期:2026-08-27Plants have evolved sophisticated immune systems to defend against a wide array of pathogens. These defence mechanisms are primarily mediated by cell surface pattern recognition receptors (PRRs) and intracellular nucleotide-binding leucine-rich repeat receptors (NLRs). Recent studies indicate that immune signalling involving PRRs and NLRs converges on cytosolic calcium (Ca) and other signals, which act synergistically to mount robust plant defences. However, uncontrolled activation of these defence mechanisms often negatively affects plant growth. In this Review, we discuss recent findings on the signalling mechanisms of PRRs and NLRs, including microbial recognition, receptor activation and signal transduction, as well as mechanisms that mitigate the negative impact on plant fitness associated with growth-defence trade-offs. We also discuss the interplay between the immune system and environmental stresses and explore strategies for engineering disease-resistant plants with optimized fitness.
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10. Not just for splicing - intronless mRNAs reveal role of nuclear speckles in nuclear export.
PMID:日期:2026-08-26该文献暂无摘要。