Chemical Engineering Journal化学工程杂志
Chemical Engineering Journal(英文缩写 CHEM ENG J),ISSN 1385-8947,eISSN 1873-3212,中文译名:化学工程杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 16.744 | Q1 |
| 2022 | 15.100 | Q1 |
| 2023 | 13.300 | Q1 |
| 2024 | 13.200 | Q1 |
| 2025 | 12.500 | Q1 |
Chemical Engineering Journal 最新收录文献
-
1. CRISPR-Programmable Nanoparticle Transport in Salt-Gated Porous Media for Visual DNA Detection.
1. 用于视觉DNA检测的盐门控多孔介质中的CRISPR可编程纳米粒子传输PMID:日期:2026-07-18Paper-based diagnostics typically treat porous cellulose as a passive capillary medium, with nanoparticle transport governed by channel geometry and capture chemistry. Here we show that CRISPR-programmable nanoparticle surface chemistry can actively regulate transport in paper through a salt-activated adhesion mechanism. Gold nanoparticles functionalized with hydrophobic Cy5-labeled DNA exhibit strong adhesion to cellulose fibers at elevated ionic strength (~1.5 M local NaCl generated upon rehydration of preloaded salt), whereas particles lacking hydrophobic domains migrate freely. This phenomenon enables a distance-based visual readout, in which the length of the colored nanoparticle front provides a semi-quantitative measure of DNA target concentration. Optical and electron microscopy reveal that nanoparticle immobilization arises from extensive fiber adhesion rather than pore occlusion or particle aggregation. As a proof of concept, coupling Cas12a-mediated cleavage of Cy5-labeled DNA probes to this salt-gated transport system enabled naked-eye, distance-based detection of Herpes simplex virus 1 (HSV-1) DNA with a limit of detection of 100 aM in ~45-60 min. Evaluation of 40 clinical samples showed excellent agreement with qPCR, achieving 96.2% sensitivity and 100% specificity. More broadly, this work establishes a general strategy for programming nanoparticle transport in porous media by encoding functionality directly into nanoparticle surface chemistry.
-
2. Bioprinting of miRNA-Induced Spheroids for Vascularized, Heterocellular Bone Regeneration.
2. 用于血管化异细胞骨再生的miRNA诱导球体的生物打印PMID:日期:2026-07-02[中文摘要] 成功的骨再生需要成骨与血管发育的耦联；然而，在工程化组织中实现多细胞同时分化仍具有挑战性。在此，我们开发了一种微小RNA（miR）引导的球体平台，以诱导人脂肪来源干细胞（hASCs）的双向成骨和内皮分化，用于血管化骨再生。hASCs分别转染miR-148b或miR-210以促进成骨和血管相关表型，并组装成球体，利用抽吸辅助生物打印（AAB）将其生物打印于含nHA的GelMA微凝胶环境中。该集成平台结合了miR引导的成骨和内皮分化、基于AAB的空间有序球体组装以及含nHA的GelMA微凝胶环境，以支持血管化骨组织再生。工程化构建体保持了高细胞活力（>90%），并支持细胞在微凝胶基质内活跃的铺展和迁移，同时成骨和内皮基因表达增加。为进一步验证其再生潜力，将构建体植入小鼠临界尺寸颅骨缺损中，与对照相比，含有miR转染hASCs的构建体改善了骨再生，实现了约91%的缺损闭合，并促进了血管样CD31阳性结构的形成。总之，这些发现表明，将miR介导的双向谱系分化与空间有序的球体组装及支持性微凝胶环境相结合，为血管化骨组织工程提供了一种有前景的策略。
[英文摘要] Successful bone regeneration requires coupled osteogenic and vascular development; however, achieving simultaneous multicellular differentiation within engineered tissues remains challenging. Here, we developed a microRNA (miR)-guided spheroid platform to induce dual osteogenic and endothelial differentiation of human adipose-derived stem cells (hASCs) for vascularized bone regeneration. hASCs were transfected with miR-148b or miR-210 to promote osteogenic and vascular-associated phenotypes, respectively, and assembled into spheroids that were bioprinted within an nHA-containing GelMA microgel environment using aspiration-assisted bioprinting (AAB). The integrated platform combined miR-guided osteogenic and endothelial differentiation, spatially organized AAB-based spheroid assembly, and an nHA-containing GelMA microgel environment to support vascularized bone tissue regeneration. The engineered constructs maintained high cell viability (> 90%) and supported active cell spreading and migration within the microgel matrix, together with increased osteogenic and endothelial gene expression. To further verify their regenerative potential, the constructs were implanted into mouse critical-size calvarial defects, where those containing miR-transfected hASCs improved bone regeneration, achieving ~91% of defect closure, and promoted the formation of vessel-like CD31-positive structures compared to controls. Together, these findings demonstrate that combining miR-mediated dual-lineage differentiation with spatially organized spheroid assembly and a supportive microgel environment provides a promising strategy for vascularized bone tissue engineering.
-
3. Remediation of Pb contaminated soil with recovered P-laden engineered biochar: Effects on Pb speciation and soil microbial community.
3. 用回收的含磷工程生物炭修复铅污染土壤：对铅形态和土壤微生物群落的影响PMID:日期:2026-03-15This study investigates the concept of using engineered biochar to reclaim phosphorus (P) in water and subsequent reuse of recovered P-laden engineered biochar for remediation of lead (Pb) contaminated soil. Hickory wood biochar (BC) was loaded with Mg oxides/hydroxides (EBC) via wet-impregnation pretreatment and Mg/Fe layered double hydroxides (LDH) via co-precipitation, respectively. Both engineered biochar types demonstrated effective P adsorption, with maximum capacities of 196.0 mg P/g for EBC and 88.3 mg P/g for LDH. The recovered P-laden biochar (EBC-P and LDH-P) were incubated with a Pb contaminated soil for four months, and changes in labile Pb content, Pb speciation, and soil microbial community were monitored. EBC-P and LDH-P significantly reduced extractable Pb (CaCl and TCLP methods) by over 95% stabilization efficiency. Soil XRD spectra indicated gradual crystallization of hydroxypyromorphite within the first month, yet this Pb mineral phase was not detected in later months by XANES. Pb was consistently bonded on biochar surfaces across all treatments. Biochar applications also altered the soil microbial community structure, increasing the relative abundance of taxa (e.g., strains) in association with increased soil pH and reduced Pb toxicity. This change suggests enhanced microbial functionalities to cope with environmental stresses such as pH and heavy metals as well as assimilation and generation of precursor metabolites. Ultimately, this study provides a technical foundation for evaluating P-enriched engineered biochar as a sustainable strategy for remediating Pb-contaminated soils.
-
4. Targeted Photodynamic Therapy for Multispecies Dental Biofilms Using Liposome Encapsulated p-Toluquinone.
4. 使用脂质体包裹的对甲苯醌对多种牙科生物膜进行靶向光动力治疗PMID:日期:2026-02-10Oral infections remain highly prevalent among individuals with limited access to routine dental care. Blue light (BL) offers a promising alternative for managing these infections, but its efficiency is limited without BL-activated photosensitizers. Here, we engineered an ionizable liposome to encapsulate a newly identified BL-activated photosensitizer, p-toluquinone (p-TQ). The resultant p-TQ@Lipo responded to the acidic pH produced by bacteria, facilitating the targeted delivery of the cargo to the pathogens. p-TQ@Lipo had a pH-dependent surface potential change from +29.5 ± 2.1 mV at pH=5, to +8.2 ± 0.1 mV at pH=7, and -6.4 ± 0.5 mV at pH=8. When combined with 405 nm BL at a fluence as low as 27 J/cm, p-TQ@Lipo reduced bacterial load by >99%, with minimal cytotoxicity to human gingival fibroblasts, achieving a remarkable 359-fold improvement in selectivity over free p-TQ. Confocal microscopy validated more efficient delivery of the cargo to Gram-negative than to Gram-positive bacteria, reflecting differences in bacterial surface charges. We then established polymicrobial dental biofilms in vivo and in vitro, comprising BL-sensitive and -refractory and Gram-positive and -negative species. The polymicrobial biofilms were efficiently disrupted on ferret tooth surfaces in an ex vivo infection model and eradicated in an in vivo mouse oral infection model by repeated therapies of p-TQ@Lipo combined with BL, whereas either treatment alone was ineffective. Importantly, the treatment significantly decreased periodontal inflammation and hyperplasia. These findings establish p-TQ@Lipo plus BL as a safe and effective antimicrobial platform with translational potentials for oral infection management.
-
5. NeuProIO: A dual-Action Solid Drug Nanoparticle Topical Formulation for Simultaneous Intraocular Pressure Reduction and Neuroprotection for Glaucoma.
5. NeuProIO：一种双作用固体药物纳米颗粒局部制剂，用于同时降低眼内压和青光眼的神经保护PMID:日期:2026-01-26Glaucoma is a leading cause of irreversible blindness, primarily due to elevated intraocular pressure (IOP) that damages the retina and optic nerve. Most topical glaucoma treatments focus solely on IOP-lowering without direct neuroprotection, as drug delivery to the posterior eye is challenging. Here, we developed NeuProIO, a dual-action solid drug nanoparticle (NP) eye drop for simultaneous IOP reduction and neuroprotection. Using flash nanoprecipitation in a multi-inlet vortex mixer, we fabricated the first NeuProIO solid drug NPs incorporating the repurposed neuroprotective agent maprotiline (MAP) and the IOP-lowering agent betaxolol (BX), forming MAP/BX NPs for synergistic glaucoma treatment. The NeuProIO improved stability and ocular biocompatibility versus conventional eye drops and markedly enhanced corneal transport. Single topical dosing sustained an effective IOP control (15% IOP reduction or higher) for 72 h. Beyond its IOP-lowering effect, BX significantly enhanced the posterior segment delivery of MAP in MAP/BX NPs, resulting in retinal and optic nerve MAP levels that were approximately 5-fold and 2-fold higher, respectively, than those observed with MAP alone. In silicone oil-induced ocular hypertension glaucoma mouse model, the MAP/BX combination exhibited significantly improved neuroprotection effects than MAP monotherapy, including >21% greater ganglion cell complex thickness, >7-fold axon preservation, and >4-fold retinal ganglion cell survival. A comprehensive biosafety evaluation confirmed the safety of NeuProIO, with assessments of corneal thickness, RGC viability, and major organ histology revealing no adverse local or systemic effects. Taken together, NeuProIO has the potential to redefine glaucoma treatment, offering a more effective and long-lasting solution to preserving vision and improving patient outcomes.
-
6. Investigating Nanoparticle Distribution and Tissue Architecture in Male and Female Human Cardiac Organoids.
6. 研究纳米颗粒在男性和女性心脏类器官中的分布和组织结构PMID:日期:2026-01-22Nanoparticles (NPs) are increasingly recognized as vital tools in targeted cardiac therapies, diagnostics, and tissue regeneration. Despite notable advancements, a comprehensive understanding of NP interactions within cardiac tissue as a whole remains limited. In this study, we employ human cardiac organoids derived from induced pluripotent stem cells to investigate NP distribution and colocalization by cardiomyocytes (CMs) and epicardial cells. We also examine the influence of organoid sex on structural organization, biomechanics, and whether such variations impact NP biodistribution and cellular internalization. Using fluorescent polystyrene NPs combined with cryo-electron, confocal, and super-resolution microscopy, RNA sequencing, and atomic force microscopy (AFM), we compare male and female organoids across multiple parameters. Our findings reveal that NPs preferentially accumulate in regions rich in CMs and extracellular matrix, with CMs showing significantly higher colocalization with NPs than epicardial cells. While super-resolution microscopy and AFM analyses demonstrate substantial architectural and mechanical differences between male and female organoids, no significant sex-based differences in NP distribution or colocalization/proximity were observed. Overall, our findings suggest two key points: (i) CMs play a pivotal role in NP-mediated cardiac therapies, and (ii) the development of cardiac organoids should incorporate additional features, such as immune system components, to better mimic native heart tissue. Such advancements would enhance the utility of organoids as robust models for studying drug and NP interactions.
-
7. {"_":"Fully Automated [F]AlF Radiolabeling Using a Microdroplet Reactor Platform.","sup":["18"]}
7. {“_”：“使用微滴反应器平台进行全自动[F]AlF放射性标记。”，“sup”：[“18”]}PMID:日期:2026-01-09The preparation of F-labeled biomolecules for PET imaging is often challenging due to complex synthesis protocols and the short half-life of F-18 (109.8 min). The aluminum-[F]fluoride ([F]AlF) method offers a straightforward, efficient route for radiofluorinating biomolecules, with demonstrated utility in both preclinical and clinical imaging. However, one technique's flaw is the mismatch between the typical microvolume conditions required for high-yield [F]AlF chelation and the milliliter-scale operation of commercial automated radiosynthesizers. To address this shortcoming, we leverage microscale radiochemistry techniques and report the first fully-automated, droplet-based production of [F]AlF-labeled compounds using a compact and cost-effective platform. The optimized process was first achieved using a NODA analogue (NODA-Tz) as a model substrate at a 15 μL reaction scale, and was subsequently applied to the fully automated synthesis of the clinically-relevant PET probe [F]AlF-FAPI-74 which targets fibroblast activation protein expressed in most cancers. [F]AlF-FAPI-74 (n = 3) was obtained with high radiochemical yield (RCY, 75 ± 5%), radiochemical purity (RCP, >99%), activity yield (67 ± 4%), and apparent molar activity ( , 358-482 GBq/μmol). Starting from 2.6-3.5 GBq of [F]fluoride, the final product quantity (1.8-2.4 GBq) was sufficient for multiple patient doses. Compared to the conventional vial-based methods, the microdroplet approach showed significant improvements including reduced synthesis time (19 ± 1 min vs. 31 min), higher yield, and reduced precursor consumption (5 nmol vs. 80 nmol). This work demonstrates the feasibility and advantages of translating [F]AlF chemistry to a microdroplet platform, enabling more efficient radiotracer production and broader clinical accessibility.
-
8. 4D Printing of a Bioadhesive Shape Memory Elastomer.
8. 生物粘附形状记忆弹性体的4D打印PMID:日期:2025-12-17Tissue adhesive materials for biomedical applications demand exceptional stretchability, flexibility, and robust adhesion. Herein, we introduce a bioadhesive shape memory elastomer (SME) that is 4D printed by digital light processing (DLP). The ink for printing this SME consists of N-vinylpyrrolidone (NVP), dodecyl acrylate (DA), and a new Poly(ethylene glycol-co-dodecanedioic acid) diacrylate (AcP) prepolymer. By employing AcP, a linear oligomer with tailored hydrophobic and hydrophilic segments, as a crosslinker, the resulting poly(AcP-DA-NVP) SME exhibits impressive mechanical and adhesion performance. Depending on the weight ratios of the ink precursors, this bioadhesive SME shows tunable transition temperatures in a range of 9-68 °C, Young's modulus of up to 24 MPa, and tensile strength of ~ 18.5 MPa, stretchability of ~ 700%, and adhesion strengths of ~ 600 kPa to dry/wet aluminum foils and 90 kPa to porcine skin. Empowered by these combinational properties, the SME offers an unprecedent capability of being a shape-programmable, adhesive substrate for on-skin soft electronics and shows potential for tissue engineering, wound healing, and biomedical implantation.
-
9. Enhancing Arsenate Adsorption Kinetics in Iron(III)-Crosslinked Chitosan Beads.
9. 增强铁（III）-交联壳聚糖珠中砷酸盐的吸附动力学PMID:日期:2025-10-16Iron(III)-crosslinked chitosan (Fe-Ch) offers great potential for the sustainable removal of arsenic from contaminated water sources due to its high adsorption capacity and selectivity for As(V) over background competitors such as phosphate (P(V)). However, this material can have low surface area and high activation energy for chemisorption, which can contribute to a low adsorption rate limiting its scalability. This study investigated parameters impacting the adsorption kinetics of Fe-Ch beads and assessed methods to improve their performance. Batch adsorption experiments and molecular dynamics simulations demonstrated that the identity of anions present during synthesis plays a significant role in the final structure and degree of crosslinking of the beads. Acetate in the synthesis was found to lead to a lower degree of crosslinking and higher surface area, enhancing adsorption kinetics. Moreover, glycine in the synthesis was found to lead to the highest adsorption rates, as its interaction with iron increases the hydrophilicity of the beads and may provide a coordination environment that has higher affinity for arsenate than crosslinked chitosan evidenced by density function theory calculations. We also compared the impact of drying techniques on adsorption performance. Freeze-dried beads were found to be rate-limited by chemisorption while air-dried beads were found to be rate-limited by intraparticle diffusion until the beads reached a swollen state. With the approaches evaluated in this study, the pseudo-second-order rate constant of Fe-Ch beads was increased by 24-fold compared to literature studies without altering selectivity, enhancing their suitability for As(V) remediation.
-
10. Tunable lysis of functionalized nanocultures for efficient microbial and nucleic acid recovery.
PMID:日期:2025-09-22The cultivation of low-abundance and fastidious microorganisms remains a critical challenge in microbiology. To overcome this, we developed -a microencapsulation platform that enables high-throughput cultivation of microbes under near-native conditions. These nanoliter-sized polymeric microcapsules are generated via droplet microfluidics and provide a mechanically robust yet tunable environment for microbial growth, isolation, and interrogation. By engineering the capsule shell chemistry, we control the mechanical properties to allow on-demand lysis and efficient retrieval of intracellular contents. We assessed three physical disruption methods-osmotic swelling, sonication, and bead beating-to evaluate their performance in releasing viable cells and nucleic acids from nanocultures. Osmotic swelling yielded the highest recovery of both viable microbes and high-integrity nucleic acids, outperforming the other methods. This approach preserves the biological relevance of the cultivated communities while enabling downstream processing for species identification and functional analysis. Nanocultures offer a scalable, high-throughput strategy to culture diverse microbial species in environments that mimic natural habitats. Their mechanical tunability provides precise control over microcapsule lysis and content recovery, positioning them as a powerful tool for microbial discovery, diagnostics, and synthetic ecology.