Monaldi Archives for Chest Disease蒙纳尔迪胸科疾病档案
Monaldi Archives for Chest Disease(英文缩写 MONALDI ARCH CHEST D),ISSN 1122-0643,eISSN 2532-5264,中文译名:蒙纳尔迪胸科疾病档案 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 1.900 | N/A |
| 2023 | 1.100 | Q4 |
| 2024 | 0.800 | Q4 |
| 2025 | 0.800 | Q4 |
Monaldi Archives for Chest Disease 最新收录文献
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1. Drug resistance in patients with tuberculosis: a study from a tertiary care center in northern India.
PMID:日期:2026-09-23Tuberculosis (TB) continues to be a major global health challenge, with India contributing a significant share of the burden. Drug-resistant TB (DR-TB) is additionally responsible for the huge numbers. Despite the magnitude of the problem, there is a relative paucity of data with respect to the different patterns of DR-TB from Northern India. A retrospective, observational study was undertaken at the Department of Pulmonary Medicine at Chest and TB Hospital, Government Medical College, Patiala, Punjab, India, to analyze the drug resistance profile of Mycobacterium tuberculosis and associated risk factors, essential for aiding clinicians and evaluating evidence to strengthen programmatic strategies, with an aim to ultimately reduce the overall burden of TB. A total of 14,142 microbiologically confirmed M. tuberculosis cases from 2022-2024 were reviewed. Resistance patterns were characterized according to national guidelines. The prevalence of resistance patterns and associations between drug resistance and demographic variables, treatment and contact history, and comorbidities (HIV co-infection, diabetes mellitus, alcohol, and smoking) were analyzed using chi-square tests and univariate and multivariate logistic regression. In this cohort, the median age of included patients was 37 years, with the majority from 21-40 years (41.01%) and predominantly male gender (60.72%). The overall prevalence of DR-TB was 8.6%. INH monoresistance accounted for 50.53% of DR-TB, with 35.99% harboring katG and 14.54% inhA gene mutations. katG mutations were significantly higher in newly diagnosed patients (37.7%, p=0.006), those with a positive contact history (37.6%, p=0.027), diabetics (43.6%, p=0.038), and individuals with tobacco exposure (49.1%, p=0.034). inhA mutations were strongly associated with HIV co-infection (32.30%, p=0.005). Rifampicin resistance was more frequent among previously treated cases (15.3%, p<0.001), patients with no contact history (13%, p=0.003), and those with HIV co-infection (19.40%, p=0.026). Multivariate analysis demonstrated that female gender [adjusted odds ratio (AOR) 1.15, p=0.030], previous treatment history (AOR 1.78, p<0.001), and absence of contact history (AOR 1.74, p<0.001) had higher odds of having DR-TB. These findings, when interpreted in the context of existing literature, suggest that factors contributing to the development of resistance are either acquired through treatment failure or community transmission. Individual host factors, including gender and the presence of comorbidities such as HIV, diabetes, and tobacco exposure, further increase the risk. Understanding the epidemiology of drug resistance is crucial to improve patient outcomes, curb the burden of TB in our region, and eventually advance the nation's TB elimination goals.
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2. Associations of light smoking with serum carcinoembryonic antigen and relative leukocyte telomere length in men with asthma.
PMID:日期:2026-09-23Smoking and asthma are associated with oxidative stress and chronic inflammation, which may contribute to accelerated cellular aging. Relative leukocyte telomere length (RTL) and serum carcinoembryonic antigen (CEA) are accessible biomarkers linked to these pathways, but their associations with light smoking (1-4 cigarettes/day) in men with asthma remain unclear. This cross-sectional study included 156 men: 73 with asthma and 83 healthy controls, classified as asthmatic light smokers, asthmatic nonsmokers, healthy light smokers, or healthy nonsmokers. Primary analyses used outcome-specific datasets after within-group Tukey 1.5×IQR exclusion, yielding 150 observations for CEA and 148 for RTL; complete-data and age-restricted analyses were sensitivity analyses. CEA differed across groups and was higher in asthmatic light smokers than in healthy nonsmokers (Dunn-Bonferroni p=0.006). In the age-adjusted full-cohort model, light smoking among participants with asthma was associated with higher CEA [adjusted ratio 1.18, 95% confidence interval (CI) 1.01-1.38; p=0.034]. This association became statistically inconclusive after broader adjustment. RTL also differed across groups and was shorter in asthmatic light smokers than in asthmatic nonsmokers (Dunnett T3 p=0.001). In the primary median-regression model, light smoking among participants with asthma was associated with lower RTL (adjusted conditional-median ratio 0.38, 95% bootstrap CI 0.22-0.67; p=0.001), but this association was not consistently retained in severity-adjusted, complete-data, and age-restricted analyses. Asthma-status×smoking-status interactions were nonsignificant for both biomarkers. Light smoking was associated with higher CEA and lower RTL in the primary models, but both findings were sensitive to analytical specification. These exploratory cross-sectional associations do not establish causality and require longitudinal confirmation.
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3. Utility of lung ultrasound in assessing severity of interstitial lung diseases: correlation with high-resolution computed tomography and spirometry findings.
PMID:日期:2026-09-21Interstitial lung diseases (ILDs) constitute a diverse category of diffuse parenchymal lung disorders whose diagnosis and monitoring are challenging due to complex clinic-radiological profiles and the risks of serial high-resolution computed tomography (HRCT). Lung ultrasound (LUS) has potential to become an easily available, non-ionizing substitute, though its comparative performance against HRCT and spirometry in severity assessment has been inadequately studied. We conducted a cross-sectional study of 52 adult ILD outpatients enrolled over one year, excluding those with cardiac failure, pulmonary tuberculosis, neoplasia, pregnancy, or acute ILD exacerbation. Each patient underwent LUS using a linear probe to determine total B-line score, total positive chest areas with ≥5 B-lines, and pleural line abnormalities; HRCT was scored by the Warrick system, and spirometry measured forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). There was a substantial correlation (r=0.75, p<0.001) between the Total B-line score (mean 39.3±15.3) and the Warrick score (11.94±5.09) and the Warrick score and total positive chest area score (r=0.77, p<0.001). Notable unfavorable associations were observed between LUS B-line score and FVC (r=-0.75, p=0.00) and FEV1 (r=-0.73, p=0.00). LUS demonstrated sensitivity of 97.9% and diagnostic accuracy of 94.2% compared with HRCT, though specificity was moderate (60%). These findings indicate that LUS closely mirrors HRCT and spirometry in assessing ILD severity. Given its high sensitivity, safety profile, and accessibility, LUS may serve as a valuable adjunct for routine evaluation and follow-up of ILD patients, particularly where repeated HRCT is impractical. Further large-scale, prospective studies are required to validate standardized LUS scoring and establish its role in guiding ILD management.
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4. To evaluate the quit rate in smoking and smokeless tobacco users accessing the National Tobacco Quitline Services, New Delhi.
PMID:日期:2026-09-21National Tobacco Quitline services are telephone-based interventions that help a vast population of tobacco users to quit all forms of tobacco. This covers smoking-related items, including cigarettes, hookahs, and bidis as well as smokeless tobacco products like khaini, gutkha, and pan masala. Quit-line has emerged as an important public health intervention that provides evidence-based, cost-effective support for tobacco quitting while achieving impressive quit rates in helping individuals quit. Telephonic interviews were used to gather data, which was based on information obtained from the National Tobacco Quitline Services (NTQLS) database between May 2016 and August 2024. Tobacco users motivated to quit were solicited to call the toll-free number and subsequently assigned to be called back four times, proactively by NTQLS. Throughout the registration procedure, participants supplied details concerning their specific types of tobacco usage, patterns of consumption, history, and personal demographic information like age, address, and other relevant data. The study recorded a total of 505,121 callers, with 346,959 (68.69%) reporting to be smokeless tobacco users, 96,765 (19.16%) as smoking users, and the rest, 61,397 (12.15%), reporting to use both smokeless and smoking tobacco. Overall quit rates were reported as 30.53% in smokeless tobacco users and 28.39% in smoking users. Most strikingly, people aged between 18 and 24 years old were the most determined to quit, with registration rates at 45.8% for smokeless tobacco and 47% for smoking tobacco. Individuals aged 55 years and above had the highest quit rate. Non-literate showed the highest smoking cessation. Government sector employees were consistent in their cessation efforts. In conclusion, the evaluation of quit rates among tobacco users gives a good understanding of cessation practices. Such findings can inform tailored interventions that aim to enhance cessation outcomes across different population groups. Future studies should continue to investigate these interactions to strengthen the effectiveness of tobacco control interventions.
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5. Non-invasive risk stratification of pulmonary hypertension in idiopathic pulmonary fibrosis: a screening approach from a prospective observational study.
PMID:日期:2026-09-18Pulmonary hypertension (PH) is a major complication of idiopathic pulmonary fibrosis (IPF), but its detection remains challenging because right-heart catheterization is invasive and echocardiography has limited accuracy in advanced lung disease. We assessed the feasibility of a multiparametric non-invasive screening approach and its concordance with echocardiographic PH probability in patients with IPF. In this prospective single-center observational study, 27 patients with multidisciplinary-confirmed IPF were enrolled from November 2024 to May 2025. Patients were classified as having low, intermediate, or high PH risk using the PH-ILD Detection Tool, incorporating clinical, functional, imaging, and biomarker variables. All patients underwent transthoracic echocardiography and were classified according to echocardiographic PH probability. No patient underwent right-heart catheterization. The PH-ILD Detection Tool classified 14 patients as low risk, 5 as intermediate risk and 8 as high risk. Echocardiography indicated low PH probability in 14 patients, intermediate probability in 4, and high probability in 9. Thirteen of the 14 patients classified as low risk had a low echocardiographic probability. Higher echocardiographic PH probability was associated with greater dyspnea severity, NT-proBNP >300 ng/L, lower resting PaO₂ and lower nadir SpO₂. The PH-ILD Detection Tool showed promising concordance with echocardiographic PH probability and may help prioritize patients with IPF for cardiovascular assessment. However, the small sample size and absence of right-heart catheterization preclude diagnostic validation, and the findings should be considered exploratory.
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6. Air pollution and chronic respiratory diseases: a narrative review including a case study in Campania (Italy).
PMID:日期:2026-09-16Air pollution is a major public health risk, contributing significantly to the global burden of chronic respiratory diseases. Chronic exposure to pollutants such as PM2.5, PM10, NO₂, and O₃ is associated with documented pathogenetic mechanisms, including oxidative stress, chronic inflammation, epithelial damage, and airway remodeling, which promote the development of respiratory diseases such as asthma, COPD, and cardiovascular disease. This review examines epidemiological data at the national and regional levels, focusing on Campania, one of the Italian regions most exposed to air pollution levels above the national average. Evidence shows a significant impact on the population's respiratory health, with socioeconomic inequalities amplifying the risks for the most vulnerable communities. Analysis of environmental, epidemiological, and pathophysiological data between 2015 and 2024 confirms that, despite a slight decrease in PM10 and PM2.5 concentrations nationwide, Campania continues to record high levels, with measurable impacts on respiratory health and significant intra-regional disparities. Artificial intelligence, through machine learning models and satellite-based forecasts, offers new opportunities for improving air quality monitoring and forecasting future trends. Furthermore, the adoption of environmental justice policies could effectively target interventions in high-risk areas. To reduce the impact of air pollution, the implementation of integrated strategies that combine environmental monitoring, health policies, and advanced predictive tools, supported by artificial intelligence, is crucial for targeted and timely intervention planning.
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7. Effects of hydromorphone and dexmedetomidine on diaphragmatic function in patients with acute exacerbation of chronic obstructive pulmonary disease receiving noninvasive ventilation.
PMID:日期:2026-09-11Sedative and analgesic agents may negatively influence diaphragmatic performance. This study sought to compare the effects of dexmedetomidine (DEXM) and hydromorphone (HM) on diaphragmatic function among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) undergoing noninvasive ventilation (NIV). In this open-label randomized controlled trial, 80 patients were randomly assigned to either the HM or DEXM group, with primary endpoints being the alterations in diaphragmatic thickening fraction (DTF) and diaphragmatic excursion (DE). Secondary endpoints included length of hospital stay, duration of NIV, and hospital mortality rates. Safety assessments involved monitoring fluctuations in mean arterial pressure (MAP), heart rate, respiratory rate (RR), minute ventilation, episodes of respiratory depression or hypotension, as well as variations in arterial partial pressure of carbon dioxide and oxygenation index. Results indicated that both DEXM and HM groups exhibited significant increases in DE and DTF (p<0.05). However, DE improvements were notably superior in the HM group than in the DEXM group (p=0.024). Additionally, NIV duration was significantly reduced in the HM group compared with the DEXM group (p=0.033). There were no significant differences between groups regarding length of hospital stay or in-hospital mortality (p>0.05). The DEXM group experienced a more pronounced reduction in MAP (p=0.032), while the RR reduction was significantly greater in the HM group (p=0.003). A significant interaction between group assignment and time was observed for RR (p=0.023). Incidents of clinically significant hypotension were infrequent and comparable between groups (p>0.05). Neither group showed evidence of respiratory depression nor any detrimental impact on overall respiratory function. The findings suggest that HM may better preserve diaphragmatic function during NIV in AECOPD. Although HM was well tolerated, clinicians should remain cautious regarding potential drug accumulation and avoid prolonged administration.
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8. Preventable yet persistent: silicosis and gaps in public health policy - a narrative review.
PMID:日期:2026-09-07Silicosis remains a critical, 100% preventable occupational lung disease that continues to persist as a global public health crisis in the 21st century. Despite decades of industrial safety knowledge, the disease is currently seeing a modern resurgence, particularly in the engineered stone industry, where high-intensity silica exposure leads to rapid, fatal disease variants. This review synthesizes current global and national evidence to highlight the staggering burden of silicosis, with a specific focus on India, where over 50 million workers are projected to be at risk by 2026. Epidemiological data from high-risk clusters in Rajasthan and Gujarat reveal localized prevalence rates as high as 69%, often complicated by a devastating "syndemic" of silicosis and tuberculosis. The persistence of this disease is fundamentally attributed to an "implementation gap" in occupational health policy, characterized by weak enforcement in the informal sector, the invisibility of migrant labor and diagnostic failures. While engineering controls and medical surveillance are established gold standards, their adoption remains inconsistent in low-resource settings. This review advocates for a transition toward a rights-based accountability model, mandatory digital reporting, and the integration of occupational health into broader public health strategies. Ultimately, eliminating silicosis requires moving beyond clinical observation toward robust inter-ministerial coordination and strict legal liability for workplace safety failures.
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9. Association between dietary live microbe intake and emphysema prevalence: evidence from the National Health and Nutrition Examination Survey 2009-2018.
PMID:日期:2026-09-07Utilizing the National Health and Nutrition Examination Survey data from 2009 to 2018, this study examines the association between dietary live microbe consumption and emphysema prevalence in 24,174 participants. Dietary live microbe intake was classified into three categories: low, medium, and high. Adjusted logistic regression models demonstrated a significant inverse relationship between dietary live microbe intake and emphysema prevalence. Participants in the medium and high intake groups showed approximately 40% [odds ratio (OR)=0.595] and 60% (OR=0.378) reduced risk, respectively (p<0.00001). Subgroup analysis revealed a stronger protective effect in males, potentially linked to their higher oxidative stress and metabolic rates. These findings suggest that dietary live microbes may reduce emphysema risk by modulating immune responses and inflammation through the gut-lung axis. However, as this is a cross-sectional study, causality cannot be established, and further longitudinal research is required to validate these findings.
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10. Relationship between fractional exhaled nitric oxide, asthma control test, and spirometry measurement in individuals with asthma receiving treatment.
PMID:日期:2026-09-07To evaluate the relationship between fractional exhaled nitric oxide (FeNO), asthma control test (ACT), and spirometry measurements in individuals with asthma receiving treatment, a cross-sectional study was conducted involving 47 diagnosed asthmatic patients. FeNO levels were measured using Eversens Evernoa FeNO, ACT scores were recorded, and spirometry (pre- and post-bronchodilator) was conducted. Correlations between these parameters were analyzed using Pearson's correlation and t-tests. The study found no statistically significant correlation between FeNO and spirometry parameters [forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC] or ACT scores. While FeNO was higher in individuals without a family history of asthma and nonsmokers, these differences were not statistically significant. Additionally, spirometry parameters showed significant improvement after bronchodilator use, but FeNO did not strongly predict lung function improvement. The findings suggest that while FeNO is useful as an indicator of airway inflammation, it may not consistently correlate with functional lung measurements or asthma control as assessed by spirometry and ACT. This highlights the need for a multidimensional approach to asthma management that combines these tools for more comprehensive disease assessment.