Journal of Tissue Viability组织活力杂志
Journal of Tissue Viability(英文缩写 J TISSUE VIABILITY),ISSN 0965-206X,eISSN 1876-4746,中文译名:组织活力杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.374 | Q1 |
| 2022 | 2.500 | Q2 |
| 2023 | 2.400 | Q1 |
| 2024 | 2.800 | Q1 |
| 2025 | 2.500 | Q2 |
Journal of Tissue Viability 最新收录文献
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1. Knowledge, attitudes, and practices of Chinese NICU nurses regarding the prevention of medical device-related pressure injuries: A cross-sectional study.
PMID:日期:2026-09-17Medical device-related pressure injuries (MDRPIs) are a major patient-safety concern in neonatal intensive care units (NICUs). Nurses play a pivotal role in prevention, yet their knowledge, attitude, and practice (KAP) regarding MDRPI prevention remain insufficiently understood. This multicenter cross-sectional study aimed to evaluate MDRPI-prevention KAP among Chinese NICU nurses and identify associated individual- and hospital-level factors. Using convenience sampling, we conducted a multicenter cross-sectional survey of registered NICU nurses across 22 provinces of China from September 2025 to March 2026. Participants completed a validated 38-item self-reported KAP questionnaire and two open-ended questions through an online platform. Null-model intraclass correlation coefficients (ICCs) were estimated to assess between-hospital clustering. Knowledge scores were analyzed using ordinary multiple linear regression because the null-model ICC was approximately 0, whereas Attitude, Practice, and total KAP scores were analyzed using hospital-level random-intercept models. Individual-level, institutional-level, and combined models were compared using the Akaike Information Criterion (AIC). Responses to the open-ended questions were summarized using structured content analysis and keyword-frequency counting. The final sample included 472 nurses from 135 hospitals. The percentages of maximum possible scores were 71.2% for self-reported Knowledge, 89.7% for Attitude, and 88.9% for Practice. The individual-level model had the lowest AIC for all outcomes. MDRPI-related training was the individual-level factor most consistently associated with KAP scores. Previous MDRPI management experience was associated with higher Knowledge, Attitude, and total KAP scores, and longer NICU experience was associated with higher self-reported Practice scores. In models that included hospital-level descriptors, hospital type, hospital level, and teaching hospital status were not independently associated with KAP scores. In open-ended responses, nasal CPAP prongs/cannula (46.8%), mechanical ventilators (45.1%), and peripheral intravenous catheters (36.4%) were most frequently perceived as high-risk devices. Hydrocolloid dressings (37.7%) and the high-lift and flat-placement method (15.3%) were the most frequently reported prevention strategies. In this multicenter convenience sample, Chinese NICU nurses reported positive attitudes and frequent self-reported preventive practices, whereas self-reported Knowledge scores were comparatively lower, especially for MDRPI staging and standardized assessment. Structured, device-specific education and experiential learning may strengthen prevention capacity. Future observational and interventional studies should test whether KAP improvements translate into better observed adherence and lower neonatal MDRPI incidence.
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2. Ferrous lactate enhances pressure ulcer healing and is associated with improved inflammatory, fibroblast, and angiogenic responses.
PMID:日期:2026-09-11Pressure ulcers (PUs), also termed pressure injuries, are chronic inflammatory wounds associated with recurrent ischemia-reperfusion (I/R), impaired fibroblast repair, poor vascularization, and delayed extracellular matrix remodeling. We evaluated ferrous lactate in hypoxia/reoxygenation-injured human dermal fibroblasts (HDFs) and in a rabbit PU model generated by cyclic magnetic compression. In HDFs subjected to I/R-like stress, ferrous lactate increased viability, proliferation, and scratch migration, reduced TNF-α, IL-6, and IL-1β, and increased IL-10 and TGF-β. For in vivo treatment, ferrous lactate was delivered topically in sodium alginate vehicle and compared with untreated, vehicle, and commercial comparator groups. On day 14, wound closure reached 94.73 ± 2.49% in the 2 mM ferrous lactate group, compared with 44.80 ± 4.18% in untreated controls, 61.90 ± 1.29% in the vehicle group, and 71.50 ± 3.80% in the commercial comparator group. Wound closure in the 2 mM group was significantly greater than that in the commercial comparator group (P < 0.05). Ferrous lactate treatment was also associated with improved re-epithelialization, granulation tissue formation, collagen deposition, and Ki67-positive cell proliferation, together with increased VEGF expression and CD31-positive vascular staining. These findings provide preliminary preclinical evidence that topical ferrous lactate promotes pressure ulcer repair.
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3. Prevalence, incidence, risk factors, and outcomes of pressure injuries in patients receiving extracorporeal membrane oxygenation (ECMO): A systematic review and meta-analysis.
PMID:日期:2026-09-09Pressure injury is a common, preventable harm in critically ill patients, yet its burden among those receiving extracorporeal membrane oxygenation (ECMO) remains poorly quantified. We aimed to synthesize the prevalence and incidence of PI in ECMO-supported patients, analyzed separately by epidemiological measure, and to summarize associated factors and clinical outcomes. We systematically searched five bibliographic databases (PubMed, Embase, Scopus, Web of Science, and CINAHL), supplemented by ProQuest and Google Scholar, for observational studies reporting pressure injury in patients receiving ECMO. Every reported estimate was classified into one of five epidemiological categories: prevalence at ECMO initiation or transfer, point prevalence, period prevalence during the index admission, cumulative incidence of ECMO-acquired PI, or incidence density, according to its baseline PI status, time origin, ascertainment window, numerator, denominator, and stage threshold. Quantitative pooling was restricted to studies reporting the same measure with a comparable structure; all other categories were synthesized narratively. Methodological quality was appraised with the Joanna Briggs Institute checklist for prevalence studies. Nine observational studies (3106 ECMO-supported patients) were included. Four adult cohorts reported the proportion of patients with at least one PI of any stage at any time during the index admission, with prevalent cases included (period prevalence); the pooled estimate across these four studies was 56.0% (95% confidence interval [CI]: 44.4-67.6; I = 78.47%). No included study reported point prevalence on a predefined assessment date. A PI was already present at admission or transfer to the ECMO center in 17.0-30.8% of patients. The cumulative incidence of ECMO- or ICU-acquired PI ranged from 4.2% to 44.4% across five studies that differed in stage thresholds, ascertainment windows, and populations, and was therefore not pooled; one study reported an incidence density of 1.7 new PIs per 100 ECMO patient-days. Reported correlates of PI included prone positioning, longer ECMO and ventilation duration, older age, male sex, and renal replacement therapy; device-related injury was predominantly endotracheal-tube-related. The burden of PI among ECMO-supported patients appears high in every epidemiological category examined, but the individual measures answer different questions and cannot be reduced to a single summary figure. Estimates should be interpreted within their category and confirmed in standardized prospective studies that report clearly defined measures of prevalence and incidence.
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4. Construction and cost-benefit analysis of a nurse-led management model for chronic wounds in vascular surgery based on the concept of integrated care.
PMID:日期:2026-09-08To establish a nurse-led chronic wound management model for vascular surgery under the concept of integrated care, and to evaluate its impact on wound healing, medical costs, and cost-effectiveness ratio. 363 patients with chronic wounds were randomly divided into the control group (conventional management model, n = 180) and the observation group (nurse-led full-process management under integrated care concept, n = 183) from January 2024 to December 2025. The wound healing rate, healing time, pain score, infection rate, recurrence rate within 6 months, nursing satisfaction, medical costs, and cost-effectiveness ratio (CER) were compared between two groups. The wound healing rate of the observation group (92.35%) was significantly higher than that of the control group (72.22%), and the healing time was significantly shorter (P < 0.05). The VAS pain score (2.01 ± 0.76), wound infection rate (3.28%), and 6-month recurrence rate (3.28%) in the observation group were all significantly lower than those in the control group (P < 0.05). Nursing satisfaction in the observation group (95.63%) was higher than that in the control group (78.89%). The average total medical cost per person in the observation group (CNY 6128.50 ± 819.40) was lower than that in the control group (CNY 8457.30 ± 962.80), and the cost-effectiveness ratio (66.37) was superior to that of the control group (117.11) (all P < 0.05). The integrated care concept-based, nurse-led chronic wound management model for vascular surgery effectively improved healing efficiency, enhanced clinical outcomes, reduced complication risks, and alleviated the medical economic burden, which warrants it to be a promotable approach for standardized management of chronic wounds.
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5. An empirical study of the "Sandwich Method" in the management of moderately severe incontinence-associated dermatitis in critically ill patients: An empirical randomized controlled study.
PMID:日期:2026-08-30To evaluate the clinical efficacy and safety of a combined regimen (termed the "Sandwich Method") utilizing ethacridine lactate, growth factors, and zinc oxide paste for the prevention and management of moderately severe incontinence-associated dermatitis (IAD) in critically ill patients. A total of 84 patients with IAD (including moderate-severe IAD and mild IAD with a PAT score ≥7) admitted to the emergency intensive care unit of a tertiary hospital in Beijing from May 2024 to April 2025 were randomly assigned to an intervention group (n = 42) and a control group (n = 42) by a random number table. The intervention group received the "Sandwich Method," which involved sequential application of ethacridine lactate-soaked gauze, growth factor spray, and zinc oxide paste. The control group received conventional care, including routine cleansing and application of tannic acid ointment. Outcomes assessed included healing rate, effective rate, mean healing time, and improvement in IAD severity (measured via the Incontinence-Associated Dermatitis Severity [IADS] score). Baseline characteristics were comparable between groups (P > 0.05). Post-intervention, the intervention group demonstrated superior outcomes: healing rate increased from 50% (control) to 71% (P < 0.05), mean healing time decreased from 8.83 ± 2.82 days (control) to 5.17 ± 1.06 days (P < 0.05), the degree of improvement in IAD scores was markedly greater in the intervention group (21.04 ± 7.29) compared to the control group (17.12 ± 11.44, P < 0.05) and daily IADS score reduction was significantly greater (4.02 ± 1.41 vs. 2.06 ± 1.27, P < 0.05). Additionally, no cases of progression from mild to moderate-severe IAD occurred in the intervention group, compared to 12% (5 cases) in the control group (P < 0.05). The effective rates were 95% (observation) and 86% (control), with no statistical significance (P > 0.05). The "Sandwich Method" significantly enhances healing outcomes, shortens recovery time, and prevents disease progression in moderately severe IAD. Its structured, cost-effective protocol offers practical guidance for clinical application.
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6. Modified Ziyun Ointment protects against high glucose-induced endothelial injury through miR-29c-3p-dependent modulation of VEGFA and AGE-RAGE signaling.
PMID:日期:2026-08-27Diabetic ulceration is a major diabetes-related complication characterized by impaired angiogenesis, persistent inflammation, oxidative stress, and endothelial dysfunction. Modified Ziyun Ointment (MZYO), derived from the traditional Zi-Yun ointment, has shown clinical benefits in wound repair, but its molecular mechanisms remain unclear. A high glucose-induced human umbilical vein endothelial cell (HUVEC) injury model was established. miR-29c-3p expression was measured by quantitative real-time PCR. Cell viability, apoptosis, and migration were evaluated using CCK-8, flow cytometry, wound-healing, and Transwell assays. VEGFA targeting by miR-29c-3p was examined using dual-luciferase reporter assays. VEGFA, AGE, and RAGE protein levels were assessed by Western blotting. The protective effects of MZYO-containing serum (MZYO-S) were investigated under high glucose conditions. High glucose increased miR-29c-3p expression and induced endothelial injury, reflected by reduced viability, enhanced apoptosis, and impaired migration. miR-29c-3p overexpression worsened these effects, whereas inhibition attenuated them. VEGFA was confirmed as a direct target of miR-29c-3p, and miR-29c-3p upregulation suppressed VEGFA while activating the AGE-RAGE pathway. MZYO-S significantly improved cell viability and migration, reduced apoptosis, increased VEGFA expression, and decreased AGE/RAGE levels in high glucose-treated HUVECs. Rescue experiments showed that miR-29c-3p inhibition strengthened the protective effects of MZYO-S, while miR-29c-3p overexpression partially reversed them. MZYO-S protects endothelial cells from high glucose-induced injury through modulation of the miR-29c-3p/VEGFA/AGE-RAGE signaling axis, supporting its potential as a candidate multi-target strategy for diabetic ulcer repair. Because the present design did not resolve the direction of regulation between VEGFA and the AGE-RAGE pathway, this axis is described as a coordinated regulatory network rather than a strictly linear cascade, and these in vitro findings require confirmation in in vivo models.
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7. Continuous sweat biomarker monitoring for early detection of sacral pressure injuries in postoperative patients: A prospective dual-zone wearable sensor study.
PMID:日期:2026-08-19To evaluate whether a dual-zone wearable sweat biosensor patch could detect biochemical signatures of sacral pressure injury earlier than standard nursing assessment in postoperative patients requiring prolonged bed rest. This prospective, observational, single-arm study enrolled postoperative patients requiring prolonged bed rest with a Braden Scale score (a validated tool for pressure ulcer risk assessment) of 18 or lower. Two flexible biosensor patches were applied simultaneously to each participant: one at the sacral pressure zone (T1) and one at a reference site (T2), continuously monitoring sweat lactate, sweat pH, and skin temperature over 72 h. Ward nurses performed daily blinded clinical skin assessments independently of sensor data. Fifty-three patients who developed sacral pressure injury were included. All three biomarker differentials demonstrated progressive divergence over 72 h, with statistically significant between-zone differences emerging from the 12-24 h interval. The biosensor system achieved a mean lead time of 34.1 h over nursing detection, with 77.4% of patients benefiting from advance warning of 24 h or more. Continuous dual-zone sweat biomarker monitoring detected evolving sacral pressure injury substantially earlier than conventional nursing assessment, providing a clinically meaningful intervention window in the majority of postoperative patients.
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8. Reliability and validity of the Turkish version of the instrument of self-care for prevention of diabetic foot.
PMID:日期:2026-08-06This methodological study was conducted to evaluate the Turkish validity and reliability of the "Instrument of Self-care for Prevention of Diabetic Foot" developed by Herrera-Guerra and Bautista-Arellano. This research is of methodological type. The study was conducted with 202 diabetic individuals followed up at a university hospital in Türkiye. Translation-back translation was used to assess linguistic validity, and the opinions of 11 experts were consulted for content validity. Confirmatory Factor Analysis (CFA) was applied to assess construct validity, and the Diagonally Weighted Least Squares (DWLS) estimator was used in the analyses. For reliability analysis, internal consistency coefficients (Cronbach's alpha and McDonald's omega) were calculated, and a test-retest reliability test was performed on 26 patients at four-week intervals. The content validity index was found to be 0.98. CFA results showed that the three-factor structure of the scale (Self-Care Monitoring, Self-Care Maintenance, and Self-Care Management) is suitable for the Turkish sample and that the model fit indices are at an excellent level (GFI = 0.989, CFI = 0.995, RMSEA = 0.055, SRMR = 0.061). Cronbach's alpha coefficients for the sub-dimensions of the scale were found to be in the range of 0.859-0.885, and McDonald's omega coefficients were in the range of 0.869-0.887. In the test-retest analysis, it was determined that there was no systematic deviation between the measurements in the Bland-Altman plots and that there was a very high level of positive correlation between test and retest scores (r = 0.992-0.994). As a result of the research, it was determined that the Instrument of Self-care for Prevention of Diabetic Foot is a valid and reliable scale in Turkish. This tool can be used as a guide in nursing care in terms of preventing diabetic foot ulcers and monitoring self-care of patients with diabetes in the Turkish population.
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9. Wearable-device geometry and tissue mechanical variability determine sacral soft-tissue loading and pressure injury risk.
PMID:日期:2026-08-01Wearable sensors and monitoring systems are increasingly used in clinical and home-care settings, often requiring prolonged contact with skin over bony prominences such as the sacrum. Tissue deformation beneath sustained loading is recognized as a key mechanical factor in pressure-induced tissue damage. However, device geometry influence on stress and strain distribution within underlying soft tissues remains insufficiently characterized. A three-dimensional finite element model of the sacral region was developed, incorporating skin, adipose tissue, muscle, and sacral bone. Two wearable-device geometries were simulated: a circular skin-mounted sensor and an elongated cable segment. Static pressures of 2, 6, 8, and 10 kPa were applied. Tissue stiffness was varied by ±10% and ±20% to represent inter-individual variability. Mechanical exposure was quantified using layer-resolved stress and strain distributions and a normalized risk index derived from cumulative histograms within a defined region of interest. Sensor loading produced predominantly superficial stress concentrations in skin, whereas cable loading redistributed mechanical exposure toward deeper tissues. At 10 kPa, strain-based risk indices in adipose tissue and muscle approached maximal values under cable loading across stiffness conditions, while stress-based risk remained highest in skin. Increasing tissue stiffness elevated stress-based risk but had limited influence on strain-based risk, especially in deeper tissues. We show that device geometry strongly determines tissue-level mechanical exposure. Sensor-like devices concentrate stress superficially, whereas cable-like geometries produce persistent strain in deeper tissues, which is relatively insensitive to moderate stiffness changes. Our results emphasize the need for geometry-aware, deformation-based assessment of wearable-device loading risk in pressure-vulnerable anatomical regions.