ALCOHOL酒精
ALCOHOL(英文缩写 ALCOHOL),ISSN 0741-8329,eISSN 1873-6823,中文译名:酒精 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.558 | Q3 |
| 2022 | 2.300 | Q3 |
| 2023 | 2.500 | Q2 |
| 2024 | 2.900 | Q2 |
| 2025 | 2.900 | Q2 |
ALCOHOL 最新收录文献
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1. Repeated adolescent restraint stress alters ethanol intake, body weight gain, and glucocorticoid excretion in male and female BALB/cJ and C57BL/6J mice.
PMID:日期:2026-11-01Alcohol use occurs in both men and women, yet preclinical alcohol research has historically focused on male rodents. Adolescent stress is a known risk factor for later alcohol misuse, but how stress history interacts with sex to influence intake remains unclear. To address this, we examined whether repeated adolescent restraint stress alters voluntary ethanol consumption in male and female BALB/cJ and C57BL/6J mice. Mice underwent 14 days of 2-h daily restraint beginning on postnatal day (PND) 37, followed by 4 weeks of binge-like ethanol drinking using the Drinking-in-the-Dark protocol starting on PND 53. Body weight and fecal corticosterone were measured to assess physiological adaptation and hypothalamic-pituitary-adrenal axis activity. Adolescent stress increased ethanol consumption in both strains, but with distinct temporal patterns. C57BL/6J mice showed a transient increase during the second week of drinking, whereas male BALB/cJ mice showed increased consumption during the fourth week. Stress delayed body weight gain in both strains, but recovery differed by strain and sex. Female C57BL/6J mice recovered by the final days of stress, whereas male and female BALB/cJ mice recovered within 2 weeks after stress ended. In contrast, male C57BL/6J mice did not recover. One week after stress cessation, fecal corticosterone remained elevated in stressed BALB/cJ mice, but not in C57BL/6J mice. These findings demonstrate that sex and genetic background shape physiological recovery from adolescent stress and subsequent ethanol consumption.
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2. Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.
PMID:日期:2026-11-01Literature suggests that there may be overlap between proneness to overeating-induced obesity and excessive alcohol drinking, and that this may occur in part via the endogenous opioid system in the nucleus accumbens (NAc). To investigate this, we used rats selectively bred for their susceptibility or resistance to diet-induced obesity (obesity-prone, OP, and obesity-resistant, OR), and examined their (1) ethanol drinking under the intermittent access two-bottle-choice procedure, (2) sucrose drinking under the intermittent access two-bottle-choice procedure, and (3) enkephalin, dynorphin, and opioid receptor mRNA in the NAc core and NAc shell. While we found no major differences in measures of sucrose drinking, male OP compared to OR rats had higher levels of 24-h ethanol drinking and preference, while female OP compared to OR rats had higher levels of binge-like (30-min) ethanol drinking and corresponding blood ethanol concentrations. In parallel, both male and female OP compared to OR rats had higher expression of enkephalin but not dynorphin mRNA in the NAc core, and males had higher expression of mRNAs encoding mu, delta, and kappa opioid receptors in the NAc core. Together, these results show that proneness to obesity is associated with excessive ethanol drinking prior to the onset of obesity. Further, they suggest that this could be driven in part through differences in the NAc endogenous opioid system, particularly for males and via the NAc core. This supports the idea that proneness to excessive alcohol drinking may share neurobehavioral mechanisms with susceptibility to diet-induced obesity.
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3. Chronic ethanol exposure alters the expression of genes associated with GPCR-related signaling in the olfactory bulb of male mice.
PMID:日期:2026-11-01Chronic ethanol exposure, a key feature of alcohol use disorder (AUD), can affect the nervous system, but its molecular impact on the olfactory bulb remains unclear. In this study, an intermittent two-bottle voluntary drinking model was established in male mice, and transcriptome sequencing was performed on olfactory bulb tissues. DESeq2 analysis identified 188 differentially expressed genes, including 68 upregulated and 120 downregulated genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome pathway database (Reactome) analyses indicated that ethanol-responsive genes were predominantly enriched in receptor-mediated signaling pathways, particularly those linked to G protein-coupled receptor (GPCR) signaling. Protein-protein interaction analysis further identified eight core GPCR-related genes. Quantitative real-time PCR (qRT-PCR) validation revealed that Cxcl10, Grp, Pcp2, and Pdyn were markedly downregulated in the ethanol group. These results suggest that chronic ethanol exposure is associated with transcriptional alterations in the male mouse olfactory bulb and may selectively affect several GPCR-related signaling components. This study provides candidate molecular evidence for further investigation of ethanol-associated olfactory dysfunction.
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4. Within- and between-visit variability and reproducibility of the oral microbiome in young adults with alcohol use disorder.
PMID:日期:2026-11-01The oral microbiome has emerged as a potential biomarker and pharmacological target in alcohol use disorder (AUD) due to its associations with alcohol use and related biological processes. However, its temporal variability and reproducibility remain poorly understood, limiting its utility. Saliva samples were obtained from participants enrolled in a randomized controlled trial of young adults with AUD. Temporal variability and reproducibility were evaluated using within-visit samples (∼4 h apart; before and after sesame oil placebo and standardized snack) and between visits (∼25 days; pre-treatment). Alpha diversity, beta diversity, differential abundance, and intraclass correlation coefficients (ICCs) were calculated at the genus and species levels. Significant within-visit differences were observed in alpha diversity, beta diversity, and the abundance of several genera and species. Snack type and time since last alcohol use explained comparable or greater variance in microbial composition than within-visit timepoint (4-6%). Although reproducibility of alpha diversity within-visit was generally low, most genera (70.3%) and species (74.6%) demonstrated at least moderate reproducibility. In contrast, no detectable systematic between-visit differences were observed in diversity or taxon abundance, and reproducibility was generally moderate for alpha diversity measures and most genera (67.6%) and species (72.2%). Despite group-level microbial shifts within-visit, individual-level microbial features were generally reproducible both within (∼4 h) and between (∼25 days) visits. No systematic group-level differences were detected between-visits. These findings support the use of the oral microbiome in AUD research while emphasizing the importance of longitudinal designs and accounting for recent exposures.
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5. Inflammatory tone stratifies depression risk across alcohol use levels: Evidence for an Inflammation-Sensitive Alcohol-Associated Depression Phenotype (ISADP).
5. 炎症音调对不同饮酒水平的抑郁风险进行分层：炎症敏感型酒精相关抑郁表型（ISADP）的证据PMID:日期:2026-11-01该文献暂无摘要。
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6. Characterization of breeding success and litter characteristics in the New Mexico Alcohol Research Center moderate drinking paradigm.
PMID:日期:2026-11-01Rodent models of prenatal alcohol exposure are a powerful tool for studying causal factors of prenatal exposure effects. Under the New Mexico Alcohol Research Center, we combined a voluntary drinking-in-the-dark (DID) paradigm with a Volumetric Drinking Monitor (VDM) system to quantify maternal ethanol (EtOH) intake, drinking duration, and drinking patterns throughout gestation and determined whether these variables altered breeding success or early offspring development. Female C57BL/6J mice received daily 2-h access to either 20% EtOH or water using the VDM system. Following a two-week acclimation period, breeding was initiated while daily drinking continued throughout gestation until parturition. Breeding success, litter characteristics, and early growth were evaluated from 176 dam-sire pairings across three breeding cohorts, yielding over 800 offspring for demographic analyses. Maternal EtOH exposure did not affect pregnancy success, litter loss, litter size, pup weight at postnatal day 10, offspring sex distribution, or weaning weight. Average daily gestational EtOH consumption and duration of preconception EtOH exposure did not predict offspring outcomes. Although EtOH-exposed dams consistently exhibited front-loading behavior, neither front-loading status nor front-loading intensity was associated with litter characteristics or early offspring growth. Moderate voluntary maternal EtOH consumption, duration of exposure, or drinking pattern did not drive litter characteristics that may affect the early-life environment (pup number and sex) or early growth markers (P10 and weaning weight). These data indicate that differences in the early postnatal environment are not likely to be responsible for long-term behavioral and neurobiological phenotypes reported in offspring produced using this paradigm.
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7. Linking adolescent alcohol use to adult behavioral flexibility: Habitual action-selection and attentional bias.
7. 将青少年饮酒与成年人的行为灵活性联系起来：习惯性行为选择和注意力偏差PMID:日期:2026-11-01Habitual behavior and attentional bias are distinct cognitive processes that contribute to inflexible behavior. While animal studies provide strong evidence for an association between adolescent alcohol use and impairments in behavioral flexibility in adulthood, such a link in human research has not yet been explored. Moreover, since reduced flexible behavior serves as a risk factor for escalating alcohol intake, continued alcohol use in adulthood may further exacerbate any deficits associated with adolescent drinking. We used principal component analysis to create composite scores for adolescent and past-year alcohol use, based on self-report measures from a healthy adult sample. Group differences in alcohol use were examined in relation to habitual responding (n = 71) and attentional bias (n = 44) toward non-drug reward cues, using two behavioral flexibility tasks. We used linear regression analyses to explore associations between alcohol use and behavioral flexibility outcomes in adults with and without a history of adolescent (before age 18) binge drinking. Adults with a history of adolescent binge drinking demonstrated greater habitual responding compared to those without such a history of binge drinking. Among this group, greater past-year alcohol use was also associated with increased difficulty disengaging attention from non-drug reward cues. These results suggest that adolescent and past-year alcohol use may differentially impact habitual responding and attentional bias towards non-drug reward cues. Notably, this is the first human study to explore both aspects of behavioral inflexibility in relation to different periods of alcohol use.
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8. Alcohol expectancies, emotional states, and alcohol-related consequences among junior college students in China: A full mediation model of alcohol consumption.
PMID:日期:2026-11-01This study examined the relationships among emotional states (positive and negative), alcohol expectancies, alcohol consumption, and students' subjectively perceived positive drinking experiences as well as subjectively perceived negative alcohol-related consequences among junior college students in Mainland China using a three-wave longitudinal design. Emotional states and alcohol expectancies were assessed at Time 1, alcohol consumption at Time 2, and alcohol-related consequences at Time 3, thereby reducing common method bias and improving temporal inference. The final analytic sample included 4439 participants. Results showed that both positive and negative emotional states, as well as positive alcohol expectancies, were significantly associated with alcohol consumption. Alcohol consumption was also positively related to both perceived short-term positive drinking experiences and harmful alcohol-related outcomes. Structural equation modeling indicated that emotional states and alcohol expectancies significantly predicted alcohol-related outcomes indirectly through alcohol consumption. Importantly, mediation analyses revealed a full mediation pattern, suggesting that psychological factors did not directly influence alcohol-related consequences once drinking behavior was included in the model. Notably, all perceived positive drinking outcomes reported by young student participants are only transient subjective feelings rather than objective benefits of alcohol; interpretations of such perceived rewards among adolescents should be treated with extreme caution, as youth episodic drinking frequently accompanies heightened risks of anxiety, depression and other behavioral problems. These findings indicate that alcohol consumption serves as a key proximal mechanism linking distal psychological antecedents to both subjectively perceived favorable harmful drinking outcomes. The results extend Self-Medication Theory and provide empirical evidence for a self-medication pathway of alcohol use, demonstrating that emotional and cognitive factors operate primarily through drinking behavior rather than exerting direct effects on alcohol-related consequences. Overall, the study highlights the importance of targeting both emotional regulation and alcohol consumption in prevention and intervention efforts among young junior college student populations in China.
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9. Ethanol exposure suppresses microglia pro-inflammatory response induced by SARS-CoV2-spike protein.
PMID:日期:2026-11-01In the central nervous system (CNS), microglial cells regulate the immune response by mediating neuroinflammation. Alcohol abuse leads to neuroinflammation and neurodegeneration in CNS. In the context of COVID-19, neuroinflammation and glial reactivity are mediated by the infection of human glial cells by SARS-CoV-2, which recognizes the angiotensin-converting enzyme 2 (ACE2) and other proteins, such as transmembrane serine protease 2 (TMPRSS2), through its surface Spike-1 protein. Although several risk factors for COVID-19 progression have been described, it remains unknown how alcohol consumption affects SARS-CoV-2 Spike protein-induced microglial reactivity. In this study, murine microglial cultures (BV-2) were exposed to ethanol alone and subsequently challenged with the Spike protein. Immunofluorescence analysis revealed that ethanol treatment (1%) did not affect the levels of the reactivity-related proteins C3 and CD86 or the phagocytic potential of microglial cells, although it reduced the number of cells exhibiting an amoeboid morphology. However, ethanol treatment prevented the Spike protein-induced increase in C3 levels, amoeboid cell numbers, and phagocytic activity. Furthermore, chronic in vivo exposure to ethanol decreased ACE2 and TMPRSS2 levels in the cerebral cortex of mice, whereas treatment with higher ethanol concentrations in vitro decreased only TMPRSS2 levels. These data suggest that ethanol exposure suppresses the ability of microglia to respond to the pro-inflammatory effects induced by the Spike protein. This impairment may contribute to the loss of microglial function in regulating the immune response and neuroinflammation in the CNS in the context of COVID-19.
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10. {"_":"Positive Allosteric GABA Receptor Modulators Reduce Ethanol Consumption and Acute Functional Tolerance.","sub":["A"]}
PMID:日期:2026-09-23Protein kinase A (PKA) phosphorylation of GABA receptor β3 subunits is a mechanism by which the PDE4 inhibitor apremilast prolongs recovery from ethanol intoxication, prevents acute tolerance, and reduces drinking in mice. In contrast, PKA phosphorylation of GABA β1 subunits is not required for apremilast's effects on tolerance and drinking. Based on these findings, we hypothesized that directly activating β3-containing GABA receptors would produce ethanol phenotypes similar to apremilast treatment. While no known compounds selectively activate β3-containing GABA receptors, positive allosteric modulators selective for β2/β3- over β1-subunit containing receptors do exist. We tested four such modulators (loreclezole, etifoxine, topiramate, and compound 2-261) on voluntary ethanol drinking and related behaviors in mice. Like apremilast, all four compounds dose-dependently prolonged recovery from ethanol-induced ataxia, prevented the development of acute tolerance, and reduced two-bottle choice ethanol consumption without altering blood ethanol clearance. Thus, both indirect activation of β3-containing GABA receptors by apremilast and direct activation by positive allosteric modulators with selectivity for β2/β3-containing receptors reduce ethanol drinking while preventing acute tolerance.