ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY环境毒理学与化学
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY(英文缩写 ENVIRON TOXICOL CHEM),ISSN 0730-7268,eISSN 1552-8618,中文译名:环境毒理学与化学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.218 | Q2 |
| 2022 | 4.100 | Q2 |
| 2023 | 3.600 | Q2 |
| 2024 | 2.800 | Q2 |
| 2025 | 3.600 | Q2 |
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 最新收录文献
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1. The risk posed by exposure to pesticides through beeswax to adult western honey bees (Apis mellifera).
PMID:日期:2026-10-03In western honey bee (Apis mellifera) colonies, beeswax can help manage bee exposure to lipophilic compounds via absorption, making the compounds bio-unavailable. However, trapped chemicals may be slowly released into the nest environment, posing risks to bees through chronic exposure. Due to their lipophilic properties (logP > 1), many insecticides used in agriculture or for Varroa destructor control in the honey bee nest can accumulate in beeswax. Via in vitro cage assays, we determined the LC50 values of six pesticides (coumaphos, amitraz, acrinathrin, chlorpyrifos, chlorfenvinphos, and bifenthrin) frequently detected in beeswax and determined if the concentrations found in beeswax pose a risk to honey bees. The LC50 values on adult bees exposed to these pesticides in beeswax did not follow the same ranking as their topical or oral LC50 values reported in the literature. The observed LC50 values (mg/g of beeswax) were: Amitraz (1.31), chlorfenvinphos (0.731), acrinathrin (0.504), bifenthrin (0.237), coumaphos (0.104), and chlorpyrifos (0.012). Based on mean beeswax residues of these compounds reported in the literature, the relative risk ranking to honey bees, from greatest to lowest risk, was: Coumaphos > acrinathrin > chlorpyrifos > amitraz > chlorfenvinphos > bifenthrin. Based on maximum beeswax residues reported in the literature, the relative risk ranking was: Coumaphos > chlorpyrifos > amitraz > acrinathrin > chlorfenvinphos > bifenthrin. Our data showed that the compounds tested do not appear to pose a significant risk to honey bee survival at concentrations in beeswax reported in the literature.
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2. Impact of Insecticide Exposure Duration on Heptageniid Mayflies.
PMID:日期:2026-10-01Neonicotinoids like clothianidin are commonly applied in agricultural areas where they leach into aquatic systems and expose sensitive aquatic insects. While mayflies are known to be highly sensitive to clothianidin, the connection between laboratory toxicity assays and exposure dynamics in natural systems is poorly explored. We conducted low dose clothianidin exposures on the mayfly Stenacron interpunctatum to better understand how the temporal dynamics of insecticide pulses into stream systems might impact aquatic insects. We found that short duration (<24 hr) exposures to clothianidin (0.7-8.9 µg/L) failed to produce noticeable lethal or sublethal effects within 10 days after the exposure ended. With continuous exposure, we found that toxic effects began within 72 hr of exposure to our highest concentration (8.9 µg/L) while lower concentrations required longer exposures to have toxic effects. These results indicate that, given the low concentrations of neonicotinoids commonly observed in agricultural surface waters, a single typical pulse duration is unlikely to have acutely toxic effects on mayfly populations. However, repeated pulses could have additive effects resulting in greater impacts.
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3. Modelling Pesticide Degradation in Soil: Influence of Chemical and Soil Properties on DT50 Prediction.
PMID:日期:2026-09-29Assessing pesticide degradation in soil is crucial for environmental risk assessment and regulatory decision-making. Traditional quantitative structure-activity relationships models rely on chemical structure to predict pesticide behavior, often overlooking the influence of soil properties. In this study, soil properties and chemical structures were integrated to investigate the key variables affecting pesticide degradation. Using two datasets-an industry-internal dataset and the publicly-available Pesticide Properties DataBase-eXtreme Gradient Boosting regression modelling and SHapley Additive exPlanations were applied to identify the most important predictors of pesticide half-life of degradation (DT50). The important molecular descriptors derived from the analysis are structural variables (number of aromatic atoms, hybridization ratios), molecular connectivity, reactivity (topological polar surface area efficiency), electronic properties (HOMO-LUMO gap, the energy difference between the lowest unoccupied and highest occupied molecular orbitals), and hydrophobicity (octanol-water partition coefficient). Equally, the following soil properties: pH, soil organic carbon content, clay content, and microbial biomass, improved predictive performance, reducing mean squared error and increasing the coefficient of determination values. Despite differences in compound composition and experimental conditions across datasets, a substantial overlap in the key predictors found to be important, was observed. The findings underscore the importance of chemical structure and soil characteristics in degradation dynamics, with the former providing the greatest predictive power and the latter still adding some important improvement to the final model. By integrating multiple variables, our approach allows for more realistic and reliable predictions of pesticide persistence and can be extended to field-related conditions, mixtures, and multiple stressors in the future, and provide support for improved environmental risk assessment and regulatory frameworks.
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5. Species-specific sensitivity to in vitro inhibition of the thyroperoxidase (TPO) enzyme by environmental pollutants for five fishes.
PMID:日期:2026-09-25Chemicals released into aquatic environments are detected in surface waters globally, and some can disrupt thyroid hormone (TH) signaling in fishes. A key protein in this pathway is thyroperoxidase (TPO), which catalyzes synthesis of THs. Inhibition of TPO is associated with decreased THs, leading to a variety of adverse outcomes. However, there is uncertainty regarding species-specific sensitivities to inhibition of TPO among fishes and whether inhibitors in mammals share that activity in fishes. Therefore, the present study applied the Amplex UltraRed TPO assay to compare in vitro sensitivities across five phylogenetically diverse fishes, namely red drum (Sciaenops ocellatus), sheepshead minnow (Cyprinodon variegatus), American eel (Anguilla rostrata), southern flounder (Paralichthys lethostigma), and spotted gar (Lepisosteus oculatus). The reference inhibitor, methimazole, and five environmentally relevant chemicals were evaluated to represent a range of potencies reported in the ToxCast mammalian-based assays. Methimazole inhibited TPO activity in all five species, with sensitivities within an order of magnitude. All evaluated chemicals, except dichlorvos, inhibited TPO activity, with all five species having similar sensitivities. Potency relative to methimazole varied across the tested chemicals, with the average potency ranking across species being methimazole > bisphenol A > chlorophene > chlorpyrifos > triclocarban > dichlorvos. Chemicals identified as TPO inhibitors in mammalian-based assays shared inhibitory activity across fishes, and relative potencies were conserved between mammals and fishes. This sensitivity was consistent across phylogenetically diverse species and is supported by the high level of conservation of TPO structure and function across vertebrate taxa. Taken together, these findings suggest that toxicity data from model fishes can be extrapolated to native species and mammalian-based ToxCast data can confidently be used as a source for predicting relative potencies of chemicals for inhibiting TPO of fishes in support of more objective ecological risk assessments.
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6. Microplastics accumulation and microbiome alterations in the freshwater pulmonate snail, Planorbella pilsbryi.
PMID:日期:2026-09-24Microplastics (MPs) are widespread in freshwater systems, particularly in riverine sediments, where they may threaten sediment-dwelling organisms such as freshwater gastropods. Despite their ecological significance, the effects of MPs on these organisms and their potential accumulation, remain largely unclear. This study investigated the effects of three types of MPs (6 µm and 45 µm polystyrene [PS] microbeads, and 100 µm polyethylene terephthalate [PET] microfibers) using the freshwater pulmonate snail, Planorbella pilsbryi, under five concentrations spanning environmentally relevant to elevated exposure levels (0, 0.1, 1, 10, 100, and 1,000 MPs/mL water). Both pristine and biofouled (microbially colonized) MPs were used to determine accumulation within the organisms and effects on mortality, reproduction, and host-associated microbiomes. Microplastics accumulation was assessed post-exposure, and a gut clearance period was incorporated to assess excretion efficiency. Reproduction was assessed by counting egg clusters, and whole-body bacterial communities were analyzed using the V3-V4 regions of the 16S ribosomal RNA gene. Snails ingested all PS microbead types, with amounts increasing with exposure concentration, with more biofouled than pristine microbeads. However, most ingested MPs were efficiently excreted, with retention proportional to concentration. While survival and reproduction were unaffected, MPs exposure altered microbial communities. High concentrations (1,000 MPs/mL) of pristine 45 µm PS microbeads significantly increased alpha diversity, while beta diversity was significantly different from controls at high and moderate (10 MPs/mL) concentrations in biofouled 45 µm PS microbead exposures, and at high concentrations in pristine 45 µm PS microbead exposures. Differential abundance analysis showed that certain bacterial genera responded only to microbeads or microfibers, while others were affected across both particle types. Overall, our findings demonstrate that substantial ingestion and retention of MPs can occur in Planorbella pilsbryi without significant effects on survival or reproduction, while still eliciting changes in the host-associated microbiome that vary with particle characteristics.
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7. MicroRNAs as Bridging Key Events in Zebrafish Cardiovascular Adverse Outcome Pathways: A Cross-Chemical Evidence Synthesis and the miR-BKE Framework.
PMID:日期:2026-09-23Zebrafish is among the most widely used vertebrate models for defining how environmental toxicants disrupt cardiovascular development, and the adverse outcome pathway (AOP) framework is the standard tool for organising this mechanistic knowledge for regulatory use. Existing cardiovascular AOPs link molecular initiating events (MIEs), such as aryl hydrocarbon receptor (AhR) activation, to apical outcomes including pericardial edema and early life stage mortality through key events measured largely at the gene and protein level. MicroRNAs (miRNAs) are recurrently dysregulated intermediates in this same causal chain across many toxicant classes, yet remain absent as formally recognised key events in the current cardiovascular AOP network. This review synthesises the zebrafish literature on toxicant-induced cardiovascular malformation, the cardiogenic miRNA circuitry governing chamber formation, looping, valve formation and electrophysiology, and fourteen cardiotoxicity-relevant AOPs catalogued in AOP-Wiki, including both structural and functional cardiac endpoints. Building on this synthesis, we propose a miRNA-bridged key event (miR-BKE) framework that formalises six criteria, four adapted from established weight-of-evidence practice, a fifth grounded in miRNA target-validation standards, and a sixth addressing taxonomic and species variability, for admitting specific miRNAs as quantifiable bridging nodes. We apply this framework, with an explicit numerical scoring rubric, across fourteen toxicant classes spanning industrial, agricultural, pharmaceutical, and consumer-product chemicals, and identify where genomics and small RNA sequencing data are sufficient, partial, predicted only, or entirely absent for formal key event inclusion. A prioritised research agenda ranks these classes by readiness for miR-BKE admission. The review concludes by discussing the framework's taxonomic, chemical-mixture, and methodological limitations, and the priority experiments needed to test it.
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8. A Flux-Based Bioaccumulation Model for Growing Organisms: Integrating Advective-Diffusive Uptake at Exchange Organs into Dynamic Energy Budget Theory.
PMID:日期:2026-09-22Bioaccumulation factors in fish vary systematically with body size, food availability, and chemical hydrophobicity, yet widely used fugacity-based models rely on size-independent empirical rate constants and cannot explain these patterns mechanistically. Here we present a flux-based model that resolves this limitation by integrating two complementary exchange theories into the Dynamic Energy Budget framework: Erickson-McKim countercurrent exchange for the respiratory (gill) pathway and plug-flow reactor kinetics for the dietary (gut) pathway. The key methodological advance is requiring simultaneous consistency among four independent flux descriptions at each exchange surface: The advective mass balance, Fick's diffusion law, the one-compartment Dynamic Energy Budget model, and the corresponding exact spatial solution-the countercurrent expression at the gill and the plug-flow expression at the gut. In both pathways, this consistency requirement uniquely determines the effective exposure concentration as a weighted combination of the outflow and body concentrations, where the weighting factor is derived from the exponential concentration profile along the exchange organ rather than postulated. The resulting series-resistance structure places the spatial correction exclusively on the diffusion resistance of each pathway, structurally guaranteeing three properties: The maximum bioconcentration factor equals the thermodynamic partition coefficient, gill and gut assimilation efficiencies are bounded below unity, and elimination rate constants scale inversely with body length for both pathways. This places the two uptake routes on equal mechanistic footing rather than extending a gill-centered formulation to diet as an afterthought. Systematic comparison with fugacity-based models across six diagnostic indicators demonstrates that the present model captures size-, food condition-, and hydrophobicity-dependent bioaccumulation patterns inaccessible to conventional approaches. A preliminary structural validation using mercury bioaccumulation data in blackhead seabream (Acanthopagrus schlegelii), where divalent inorganic mercury (Hg(II)) and methylmercury exhibit contrasting respiratory- and dietary-dominated kinetics, confirms the predicted size dependence of depuration rates and field concentrations.
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9. A Gaussian process approach facilitates the identification of robust biomarkers for exposure to complex pesticide mixtures.
PMID:日期:2026-09-19Biomarkers can provide a high-throughput and accurate assessment of the impact of complex chemical mixtures in the environment on organisms, but their identification through gene expression analysis is hindered by noise, synergistic interactions, and non-linear expression patterns. We generated finely resolved transcriptomic data from the ecotoxicological model species Folsomia candida exposed to two binary pesticide mixtures: One combining two neonicotinoid insecticides (imidacloprid and clothianidin) and the other a neonicotinoid (imidacloprid) with an azole fungicide (cyproconazole). Using these datasets, we developed a Gaussian Process (GP) framework to identify robust gene expression biomarkers, accounting for non-linear and synergistic interaction effects across experiments. Joint analysis of two binary mixtures increased the overlap of differentially expressed genes (DEGs) compared to separate analyses, improving robustness. In simulations, GP models outperformed linear models, accurately fitting complex, non-linear concentration-response relationships. Four biomarkers, three for neonicotinoids (ARRD, SMCT and nAchR) and one for azole fungicides (CYP), identified through this framework, were empirically validated and confirmed to be specifically responsive to their target pesticide, even under co-exposure. These findings highlight the effectiveness of GP models for mixture exposure transcriptomics and their broader applicability to other omics data and research fields.
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10. Chemical residues in agricultural land in Germany between 2022 and 2024 - prevalence of selected antibiotic resistance genes in soil.
PMID:日期:2026-09-17Growing concern about antibiotic resistance genes (ARGs) in agricultural soils, particularly due to application of organic fertilizers-has increased the need to better understand environmental reservoirs and mechanisms of antimicrobial resistance and their potential risks to human and animal health. In this study, soils from 51 agricultural sites across Germany were sampled between 2022 and 2024 aiming to determine the antibiotic resistance occurrence and pharmaceutical product contamination in the soils, and to evaluate the influence of different fertilization practices (mineral, organic, or combined). In addition, three reference soils from the German Environmental Specimen Bank (ESB) were investigated to provide background levels with minimal anthropogenic influence. The relative abundance of targeted ARGs was quantified using quantitative PCR (qPCR). Resistance genes associated with macrolides (ermB) and tetracyclines (tetA) were most frequently detected, whereas aminoglycoside (aacC4, aadA1) and trimethoprim (dfrA1) resistance genes occurred only sporadically. Other ARGs, including those conferring resistance to β-lactams (blaCTX-M1), quinolones/fluoroquinolones (qnrS), and colistin (mcr-3), were not detected, indicating low abundance or absence in the evaluated sites. The class 1 integrase gene (intI1), indicative of mobile genetic elements (MGE), was detected at nearly all sites. ARG abundances varied among sites and were generally higher in soils receiving slurry/manure, while reference soils showed consistently lower ARG prevalence. Although direct causal links between antibiotic residues and ARG occurrence could not be established due to generally rare detections of antibiotics, the observed spatial co-occurrence of high ARG findings and high sales of veterinary antibiotics underscores the importance of jointly evaluating chemical exposure, agricultural management and resistance determinants in risk assessments of soils.