NEUROBIOLOGY OF AGING衰老神经生物学
NEUROBIOLOGY OF AGING(英文缩写 NEUROBIOL AGING),ISSN 0197-4580,eISSN 1558-1497,中文译名:衰老神经生物学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.133 | Q2 |
| 2022 | 4.200 | Q2 |
| 2023 | 3.700 | Q2 |
| 2024 | 3.500 | Q2 |
| 2025 | 4.000 | Q2 |
NEUROBIOLOGY OF AGING 最新收录文献
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1. Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.
PMID:日期:2026-09-21Although cortical thinning and atrophy are well documented in aging and neurodegenerative disease, the cortical structural features associated with preserved or superior cognition across typical adulthood remain incompletely characterized. We examined associations between cortical thickness and cognitive performance in a large, typically aging cohort and tested whether they vary by age and cognitive domain. We analyzed cross-sectional data from cognitively healthy adults in the Human Connectome Project-Aging/Aging Adult Brain Connectome, spanning middle (36-59 years), early older (60-79), and late older (80 +) adulthood. Sex-stratified, age-residualized factor scores for memory, fluid, and crystallized abilities classified participants as high, middle, and low performers. Whole-brain cortical thickness was compared across groups. Descriptively, the largest and most consistent effects were observed for fluid abilities in midlife, with higher performance associated with greater thickness in bilateral somatomotor, visual, and auditory cortices. These effects spanned multiple sensory and motor regions and were replicated in stringent subsamples, including longitudinally stable and cross-domain high-performance groups. The observed patterns appear to be driven primarily by reduced thickness in low performers rather than by a distinct structural signature of high performers. Differences in cortical thickness between performance groups diminished with advancing age. These findings are consistent with the possibility that greater cortical thickness in sensory and motor cortices reflects a developmental structural advantage associated with higher fluid intelligence during middle adulthood. However, this advantage may not be sufficient to sustain high cognitive performance in later life, when other neural mechanisms may become increasingly important.
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2. Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.
PMID:日期:2026-09-21Chronic inflammation is a common feature of aging and is observed across various age-related neurodegenerative diseases, including Alzheimer's disease (AD). Diffusion magnetic resonance imaging (dMRI) metrics of white matter microstructure are hypothesized to be sensitive to inflammation, though few studies have assessed this relationship in non-clinical populations. This cross-sectional study of 457 dementia-free older adults (M=63.82) examined associations of plasma markers related to inflammation with white matter microstructure metrics from multi-shell dMRI Neurite Orientation Dispersion and Density Imaging (NODDI) and conventional, single-shell dMRI metrics. Plasma inflammatory markers included high-sensitivity C-reactive protein (CRP), a composite of pro-inflammatory cytokines, and glial fibrillary acidic protein (GFAP), a measure of astrocytic activation. Higher cytokine composite levels were associated with higher cerebral free water fraction (FWF) and higher cerebellar peduncle orientation dispersion index (ODI). Higher CRP was associated with higher cerebral and cerebellar ODI, which was non-significant after adjusting for additional demographics and vascular risk factors. Higher GFAP was associated with lower cerebral FWF and lower cerebral and cerebellar neurite density index (NDI). The only significant association with conventional DTI metrics was between higher cytokine composite levels and higher cerebral mean diffusivity (MD). Results were consistent after accounting for plasma AD biomarkers. Thus, higher levels of peripheral pro-inflammatory markers are associated with white matter microstructure (FWF, ODI, NDI, and MD), supporting the sensitivity of these dMRI-based metrics to inflammatory processes. Additionally, the sensitivity of dMRI-based measures to inflammation may differ by inflammatory marker types, with multi-shell approaches like NODDI providing information beyond conventional, single-shell dMRI.
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3. Bilingualism modulates baseline brain-cognition relationships in aging: Evidence from the HABS-HD cohort.
3. 双语调节衰老中的基线脑认知关系：来自HABS-HD队列的证据PMID:日期:2026-09-17Bilingualism has been proposed to confer advantages in cognitive aging, yet the neural mechanisms underlying any such advantages remain debated. In a pre-registered analysis of cross-sectional and longitudinal data from elders in the HABS-HD cohort, we asked whether bilingualism is associated with three measures of brain structure (total brain volume, hippocampal volume and white-matter lesions) and/or moderates the relationship between brain structure and two measures of cognition (executive function and episodic memory). Overall, we found no significant differences between bilinguals and monolinguals in their baseline brain structure or subsequent change in brain structure, suggesting that a life of bilingualism was not clearly associated with Brain Reserve or Brain Maintenance in old age. In baseline analyses, bilingualism moderated the relationship between total brain volume and executive function, and between hippocampal volume and episodic memory, such that these cognitive functions were less dependent on these brain measures in bilinguals, consistent with the concept of Cognitive Reserve. However, any effect of bilingualism on longitudinal associations between brain-change slopes and cognitive-change slopes did not reach significance, suggesting that bilingualism-related Cognitive Reserve may be limited to baseline differences. Further, exploratory analyses showed that the effects of bilingualism on hippocampal volume, and on its relationship with episodic memory, might differ according to clinical dementia status. In summary, our findings suggest that bilingualism is associated with altered baseline brain-cognition relationships, rather than with preservation of brain structure.
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4. The effect of neurodegeneration on ultrasonic vocalisations (USV) and their neuronal substrates in mice and rats: A systematic review.
PMID:日期:2026-09-17Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Frontotemporal Degeneration, significantly impair communication abilities in humans. Animal models, particularly rats and mice, are widely used to study the underlying mechanisms of these disorders. Ultrasonic vocalisations (USVs) play a crucial role in signalling emotional states during social interaction, mating, and distress and may reflect low versus high arousal and/or a positive versus negative affective state of the animal, making them valuable behavioural biomarkers for neurological dysfunction. This systematic review synthesises the existing literature on USVs in rodent models of neurodegeneration. Specifically, it compares USV alterations across disease models, summarises the experimental paradigms used to elicit USVs, and reviews the neurobiological findings reported alongside these vocal changes. By integrating findings across studies, this review highlights consistent patterns, methodological differences, and current knowledge gaps to guide future research. Studying USV impairments in animal models may help to neurobiologically validate biomarkers based on the detection of acoustic changes in the vocal output of patients with neurodegenerative diseases. By bridging the gap between preclinical and clinical research, this review aims to contribute to the growing field of neurobehavioral biomarkers, which could ultimately improve early diagnosis and intervention in human neurodegenerative conditions.
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5. Neuropathology of centenarians and supercentenarians: An autopsy study.
5. 百岁老人和超级百岁老人的神经病理学：尸检研究PMID:日期:2026-09-16Studies of centenarians and supercentenarians provide insight into aging and substrates of cognitive impairment at the extreme limits of age. In this study, we examined pathologic findings in 15 centenarians (99-109 years) and 7 supercentenarians (111-115 years) who underwent autopsy at our institution during a 25-year period between 2000 and 2025 and compared them with a cohort of 24 older adults (70-90 years) who underwent autopsy during 2024-2025. Of the 22 centenarians and supercentenarians, 15 underwent full autopsies and 7 had brain only examinations. The average age at death of the centenarians/supercentenarians was 105 ± 5.8 years (5 males and 17 females). Of those who underwent a complete autopsy, the most common cause of death was pneumonia in 10 individuals followed by cardiac amyloidosis in 5. There was a wide spectrum of Alzheimer disease (AD) neuropathologic change with some individuals showing modest AD changes despite their advanced age. Amyloid plaque burden did not differ between older adults, centenarians and supercentenarians, but centenarians/supercentenarians had a higher burden of neurofibrillary tangles. Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) was seen in 59% of centenarian/supercentenarian participants compared with 29% of older adults while hippocampal sclerosis (HS) was seen in nearly half of centenarians and supercentenarians but not in older adults. Centenarians and supercentenarians had a higher frequency of aging-related tau astrogliopathy (ARTAG) in the frontal lobe compared with older adults (36% vs 4%). Furthermore, a higher proportion of centenarian and supercentenarian individuals demonstrated more severe cerebrovascular disease, including atherosclerosis of the basal vasculature, moderate to severe arteriolosclerosis and lacunar infarcts and microinfarcts. Thus, although our findings are based on a convenience sample and may not be generalizable to all centenarians and supercentenarians, individuals at the extreme limits of age had a high frequency of ARTAG, LATE-NC, HS, and cerebrovascular disease.
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6. Spatial brain structures are selectively preserved during aging in homing pigeons (Columba livia), an avian spatial specialist.
6. 鸟类空间专家信鸽（Columba livia）在衰老过程中选择性地保留了空间脑结构PMID:日期:2026-09-14Pigeons (Columba livia) rely heavily on spatial cognition for navigation. As such, this species is commonly used to investigate the neural correlates of spatial behaviours in birds, particularly the hippocampus and septum. As this species can live for decades when housed in the laboratory, several studies have recently used pigeons to examine long-term effects of aging on the brain, a concept that is less well-understood in birds compared to mammals. Studies assessing age-related structural plasticity in the pigeon brain have yielded mixed findings, possibly due to methodological differences. Here, we used Nissl-stained brain sections collected from homing (racing) pigeons (N = 29) ranging in age from 2 to 22 years old (divided into "adult", "old", and "very old" groups), and a standard histological volume reconstruction method, to assess brain-wide age effects (volume of the overall telencephalon) as well as effects specifically on spatial (hippocampus, septum) and non-spatial (entopallium) structures. Overall, we found that telencephalon and entopallium volumes declined with age, whereas hippocampus and septum volumes remained stable across the lifespan. We also detected a modest positive correlation between age and hippocampus volume, suggesting hippocampus volume increases as pigeons age, although this finding should be interpreted cautiously. Overall, our results suggest that in pigeons, neural structures and circuits supporting spatial cognition appear to be selectively preserved relative to other brain regions during aging, and more broadly, that age-related structural changes in the avian brain are not shaped only by generalized senescence, but by functional and behavioural demands placed on specific structures and circuits across the lifespan.
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7. Individual Differences in Cognitive Aging Rodent Datasets (ID-CARD): A collaborative platform for behavioral analysis across the lifespan.
7. 认知衰老啮齿动物数据集的个体差异（ID-CARD）：一个用于终身行为分析的协作平台PMID:日期:2026-09-10Understanding cognitive aging requires approaches that capture individual variability while enabling integration across studies. In rodent models, behavioral data are central to this effort, yet cross-laboratory differences in experimental design limit comparability and constrain secondary analysis. To address this gap, we developed the Individual Differences in Cognitive Aging Rodent Datasets (ID-CARD), a first-of-its-kind collaborative repository aggregating trial-level Morris water maze data from multiple laboratories. ID-CARD is designed to support large-scale, integrative analyses and to facilitate secondary use of existing behavioral data in alignment with emerging data-sharing and transparency initiatives. Rather than imposing retrospective harmonization of experimental protocols, we implemented a normalization and modeling framework that enables comparison of learning trajectories while preserving meaningful variation across studies. Behavioral data from > 5000 rats spanning common strains, both sexes, and multiple ages were normalized in training and performance domains and fit with a logarithmic function to derive an error accumulation rate coefficient (EARC) as a measure of spatial learning. Age was strongly associated with increased EARC, indicating attenuated learning, even after adjusting for non-spatial cue performance. Analyses of goodness of fit revealed systematic structure in learning dynamics, where age was associated with reduced learning-curve conformity after accounting for overall performance. Inter-individual variability in spatial learning also increased with age, with strain-specific interactions. These findings demonstrate that integrated analysis of heterogeneous behavioral datasets can yield robust, individual-level insights into cognitive aging. ID-CARD provides a scalable resource and analytic framework to advance discovery in behavioral neuroscience by enabling reuse, integration, and comparative analysis of existing data.
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8. Detecting dynamic pathways and risk indicators of resilience, vulnerability and stability in normally aging females and males: Integrating data-driven longitudinal and machine learning analyses.
8. 检测正常衰老女性和男性中韧性、脆弱性和稳定性的动态通路及风险指标：整合数据驱动的纵向分析和机器学习分析PMID:日期:2026-09-08Resilience has become an integral component of theory and research in brain aging. Recent frameworks have provided guidelines for identifying and investigating resilience in the context of diversity (e.g., sex and risk exposure differences). We leverage a multi-factorial longitudinal approach to operationalize and predict pathways of resilience, stability and vulnerability as a function of differential within-person trajectory patterns of hippocampal volume and cognitive change. Participants included cognitively unimpaired (at baseline) older adults (n = 415; M age = 74.9; 59.9% Female) from the Alzheimer's Disease Neuroimaging Initiative with longitudinal imaging and cognition data, plus multimodal risk indicators. We used latent class growth analyses to identify hippocampal and cognitive trajectory classes. Machine learning applications identified risk indicators associated separately by pathway in the entire sample and disaggregated by sex. Based on differential combined class membership, we identified three subgroups: resilience (declining hippocampal/stable cognitive trajectories), stable (stable hippocampal/stable cognitive trajectories), vulnerable (stable hippocampal/declining cognitive trajectories). Leading risk indicators of resilience (e.g., lower plasma Aβ1-42) and vulnerability (e.g., lower education) originated from the biological and demographic domains. Leading risk indicators of stability originated from the biological and genetic domains (e.g., higher CSF Aβ1-42, lower polygenic hazard score). Sex-disaggregated results highlighted indicators unique to the females, such as higher body mass index (stability) and lower geriatric depression score (stability, vulnerability). Pathway patterns of resilience, stability and vulnerability were characterized objectively in initially cognitively unimpaired older adults based on specified hippocampal and cognitive trajectory combinations. Risk factors from a broad range of modalities should be considered in future research.
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9. Regional distribution of mineralized blood vessels in Alzheimer disease and clinicopathological associations: A multicenter autopsy study.
9. 阿尔茨海默病中矿化血管的区域分布及其临床病理关联：一项多中心尸检研究PMID:日期:2026-09-03Mineralized blood vessels (MBV) are a form of vascular pathology associated with cerebrovascular aging and neurodegeneration; however, their regional distribution and clinicopathological correlates in Alzheimer disease (AD) remain poorly characterized. We examined 265 decedents with intermediate/high AD neuropathologic change from three Alzheimer's Disease Research Centers (Columbia University, University of California San Diego, and University of California Davis). Hematoxylin and eosin-stained sections from the posterior hippocampus, putamen, and globus pallidus were evaluated for MBV. Associations with demographic, clinical, genetic, and neuropathological variables were assessed using bivariate tests and multivariable logistic regression adjusting for age at death, sex, ethnicity, and center. MBV frequency differed across regions, with highest involvement in the globus pallidus (58.3%), followed by the posterior hippocampus (28.6%), and putamen (13.8%) (all pairwise p < 0.001). After covariate adjustment, MBV presence was not associated with sex, ethnicity, education, APOE ε4 carrier status, or cerebral amyloid angiopathy (CAA). After correction for multiple comparisons, MBV remained associated with état criblé in the putamen and globus pallidus (both FDR-adjusted p < 0.01), and concomitant Lewy body disease remained associated with reduced MBV presence in the posterior hippocampus and globus pallidus (both FDR-adjusted p < 0.05). Nominal associations with a history of transient ischemic attack (TIA) did not remain significant after correction for multiple comparisons. This study identified MBV as a regionally selective feature of cerebrovascular aging in AD, enriched in deep gray matter. MBV may contribute to regional vulnerability and pathological heterogeneity in the aging AD brain.
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10. Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement.
10. 老年APOE4小鼠在小胶质细胞APOE2替换后表现出适度的免疫代谢适应PMID:日期:2026-09-02Apolipoprotein E (APOE) genotype is the strongest genetic determinant of late-onset Alzheimer's disease (AD) risk. Of its three common isoforms, E4 increases AD risk and promotes inflammatory and metabolic dysregulation, whereas E2 is protective and is associated with altered lipid handling and immune function. Microglia express APOE in response to stress or injury and exhibit isoform-dependent transcriptional profiles, but the specific contribution of microglial APOE to these phenotypes remains unclear. Here, we used an inducible APOE "switch" model to selectively replace microglial E4 with E2 in older adult mice while maintaining E4 expression in other CNS and peripheral cells. Following a Western diet, microglial E2 replacement was associated with fewer phago-lysosomal microglia and decreased apoE localization within these phago-lysosomal microglia. Following a peripheral inflammatory stimulus (LPS), microglial E2 replacement was linked with increased expression of metabolic and immune-related pathways. Together, these findings indicate that microglial E2 expression is associated with selective cellular and transcriptional changes while E4 continues to be expressed by other cell types.