INTERNATIONAL JOURNAL OF COSMETIC SCIENCE国际化妆品科学杂志
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE(英文缩写 INT J COSMETIC SCI),ISSN 0142-5463,eISSN 1468-2494,中文译名:国际化妆品科学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.416 | Q3 |
| 2022 | 2.300 | Q3 |
| 2023 | 2.700 | Q2 |
| 2024 | 2.500 | Q2 |
| 2025 | 2.600 | Q2 |
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE 最新收录文献
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1. Lignan-rich Norway spruce (Picea abies) resin extract exhibits anti-inflammatory, skin-regenerative and anti-acne effects: In vitro, in silico, biocompatibility and exploratory clinical findings.
PMID:日期:2026-09-11To investigate the antimicrobial, anti-inflammatory and early pro-repair properties of Picea abies resin extract and a 30% extract-based cream and to explore preliminary in-use performance, tolerability and cosmetic acceptability in adults with mild acne. The chemical composition of the extract was characterized by GC-MS. Anti-Cutibacterium acnes activity was evaluated by minimum inhibitory concentration (MIC) determination, time-kill testing and an inoculated-cream model. Anti-inflammatory and pro-repair effects were assessed in LPS-stimulated human keratinocytes by measuring IL-1α, IL-6 and IL-8, and in normal human dermal fibroblasts by cellular protein synthesis. Mechanistic plausibility was explored by Glide SP docking against AlphaFold2-generated models of IKKβ, JNK1, NF-κB and PPARγ. Safety was evaluated by ISO 10993-5 agar diffusion and a 48-h human patch test, and clinical performance was explored in a 28-day, open-label, uncontrolled in-use evaluation involving adults with mild facial acne. GC-MS identified p-coumaric acid, resin acids and the lignans pinoresinol, isolariciresinol and secoisolariciresinol as major constituents. The extract showed an MIC of 30% against C. acnes and, at this concentration, achieved a > 4.9-log reduction after 8 h, whereas the cream containing 30% extract achieved a 4.03-log reduction after 8 h in the inoculated-cream model. In LPS-stimulated keratinocytes, the cream reduced IL-1α by 14-17%, IL-6 by 22-39% and IL-8 by 16-26%. In dermal fibroblasts, cellular protein synthesis increased by 35-50% within 24-48 h. Docking identified putative interactions of lignans and p-coumaric acid with IKKβ, JNK1, NF-κB and PPARγ, providing hypotheses for further mechanistic investigation. No cytotoxicity or irritation was observed. In an exploratory open-label 28-day in-use study (n = 31), total lesions decreased 26.8% (p < 0.0001), papules 52.1% (p = 0.001) and comedones 17.6% (p < 0.0001), with 87% favourable acceptability and no reported intolerance. Picea abies resin extract and the extract-containing cream demonstrated antimicrobial, anti-inflammatory and early pro-repair activities in preclinical models, with good tolerability. Docking identified potential compound-target interactions that may help guide future mechanistic studies. The exploratory 28-day in-use evaluation provided preliminary signals of reduced papules and comedones/microcysts and good cosmetic acceptability. These findings support further mechanistic investigation in adequately powered, randomized, vehicle-controlled clinical studies.
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2. A novel biomimetic hair colouring system based on the eumelanin precursor 5,6-dihydroxyindole.
PMID:日期:2026-09-11The use of traditional hair dyeing agents to dye hair may cause scalp and hair damage, induce melanocyte stem cell depletion, and in some cases trigger allergic reactions. Therefore, we explored a novel hair colouring approach using 5,6-dihydroxyindole (DHI), a precursor of eumelanin, to dye grey hair. This study aimed to elucidate the mechanism by which cationic polymer pretreatment enhances the dyeability of DHI, focusing on changes in hair surface charge and the dyeing mechanism of DHI. Dyeability was assessed by UV-Vis spectrophotometry. The degree of cationization at different pH values was determined by colloid titration, and the hair surface potential was measured using a zeta potential analyser. Adsorption and penetration behaviours were evaluated by confocal fluorescence microscopy with ionic fluorescent dyes. Cross-sections of DHI-dyed hair were examined by optical microscopy. Pretreatment with a specific cationic polymer increased the dyeability of DHI-based formulations. A polymer capable of retaining positive charge under alkaline conditions (pH 10) was identified, and its suitability was confirmed by degree of cationization measurements, zeta potential shifts and fluorescence adsorption imaging. Mechanistic analyses indicated that water-soluble DHI is retained within the δ-layer of the cell membrane complex in the cuticle region, where it undergoes air oxidation and polymerization, resulting in fixation within the hair. Cationic polymer pretreatment enhances DHI dyeability and may support the development of DHI-based formulations as potential alternatives to oxidative hair dyes.
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3. Cool versus warm water for facial cleansing: A randomized controlled clinical study of skin barrier, skin physiology, cleansing efficacy and water consumption.
PMID:日期:2026-09-10To quantify the effects of water temperature and tap-running behaviour during routine facial cleansing on skin barrier function, skin physiological parameters, make-up-removal efficacy and the associated water and energy consumption. In a 10-day, randomized, controlled clinical study, 52 healthy adults (46 women, 6 men; aged 19-72 years) cleansed their face daily using ELEMIS Pro-Collagen Cleansing Balm under one of four conditions: cool or warm water, with the tap either turned off during cleansing or left running. Participants were blinded to the environmental objectives. Water usage was covertly recorded with calibrated meters on the hot and cold feed pipes. Transepidermal water loss (TEWL; Tewameter® TM 300), skin hydration (Corneometer® CM 825), skin pH (skin pH-meter PH 905) and skin radiance and translucency (TLS-850®, Diastron Ltd) were measured at baseline and on days 1, 2, 4, 7 and 10. Make-up-removal efficacy was evaluated colourimetrically following standardized light- and heavy-make-up regimens. Cumulative effects on TEWL were summarized as area under the curve (AUC) over 10 days. Between-group differences were tested with two-way ANOVA, the Mann-Whitney U test and the Wilcoxon rank-sum test; α = 0.05. Warm-water cleansing used on average 27% more water per cleansing event than cool-water cleansing (p < 0.04). Repeated warm-water cleansing produced a statistically significant increase in TEWL of approximately 3.4 g·m·h at day 10 (p < 0.01), consistent with impairment of barrier function, whereas cool-water cleansing produced no significant change (Δ ≈ 1 g·m·h; p = 0.15). Cool-water cleansing was associated with a small but statistically significant fall in skin surface pH (Δ -0.4 pH units, p < 0.02), whereas pH was unchanged with warm water. Stratum-corneum hydration declined modestly in all groups. Make-up-removal efficacy did not differ significantly between water temperatures (p > 0.05 for all colourimetric comparisons), with both regimens returning skin colour values to baseline. Routine facial cleansing with cool water preserves skin barrier integrity, supports a more favourable skin surface pH and matches the make-up-removal performance of warm-water cleansing while substantially reducing water and energy consumption. Cool-water cleansing offers a behaviourally accessible route to combine measurable skin benefits with a reduced environmental footprint.
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4. Decoding beautiful ageing in the boomer generation: Insights from a cross-generational study with American women.
PMID:日期:2026-09-10Age is a component of our social identities, shaped by social processes and cultural norms. This study aimed at decoding the beautiful aspects of ageing in the US Boomer population and assessed whether younger and older generations of people perceive ageing differently. The photographs of 218 models aged 60-70 years were rated by a panel comprised 190 American women aged 18-65 years, both cohorts being recruited with all phototypes and diverse ethnic origins. A questionnaire with seven criteria relative to skin ageing (beautiful, radiant, confidence, healthy, vibrant, my skin looks like her, happy) was used for subjective assessment. The panel rated the photographs on a 10-point scale while an AI-based algorithm graded 14 facial signs pertinent for further analysis. The study reveals no significant difference between young and older judges in rating pictures, indicating a shared perception across age groups but differing in terms of intensity. Despite cultural variations such as ethnicity, phototype, and age, the interpretation of the photographs is consistent. Furthermore, except for pores, all clinical signs show a negative correlation with perceptions. Whether evaluating photographs of elderly individuals or their peers, both age groups exhibited similar interpretations, highlighting a novel trend in the perception of ageing. These findings suggest a universal understanding of ageing indicators across different demographics. This study privileged the perception of positive ageing and the significant impact on social or psychosocial relations. Indeed, findings shed light on the intricate interplay between clinical signs and subjective perception, providing valuable insights into the underlying mechanisms of age perception. The outcome of this study paves the way towards integrating online and offline services with accurate algorithms tailored for boomers, opening the road for new holistic experiences. Additionally, this study also offers insights into the concept of perceiving ageing more positively and its link to longevity.
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5. Environmental and lifestyle determinants of skin ageing: Association between skin dryness and dyspigmentation in Chinese women.
PMID:日期:2026-09-10To evaluate and classify the effects of seasonal and environmental variations on skin ageing features-specifically pigmentation disorders and dryness-in vivo in an Asian female population. The skin characteristics of 200 Chinese women aged 20-70 years, residing in rural (YiXing) and urban (Shanghai) areas, were assessed during two representative seasons-late winter (March) and early summer (June)-to explore the relationship between seasonal or environmental variations and skin ageing manifestations. Phototype was classified using the Fitzpatrick Scale; dyspigmentation was rated with a six-grade photographic scale; and dryness was evaluated using both self-reported and expert-administered questionnaires. Statistical analyses examined associations between dyspigmentation and dryness, stratified by locality and season. Dyspigmentation and skin dryness were significantly more prevalent among rural participants in both March and June. Skin dryness was more marked in winter, suggesting a relatively short-term (from daily to monthly) evolution due to external conditions such as cold weather. On the opposite, dyspigmentation showed little seasonal variation-a pattern more consistent with a dependence on cumulative exposure rather than on short-term seasonal changes. A statistically significant correlation was observed between skin dryness and dyspigmentation across localities and seasons. This study identifies a significant correlation between skin dryness and dyspigmentation in Chinese women, consistent across localities and seasons. Both parameters were also influenced by seasonal and lifestyle factors, supporting their potential as morphological markers of the exposome's impact on skin health and ageing in both rural and urban settings. Further research, including in vitro models, is needed to elucidate the mechanisms potentially linking skin dryness and dyspigmentation.
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6. Enlarged facial pores are associated with skin barrier impairment and microbiome dysbiosis in young Chinese women.
PMID:日期:2026-09-10Enlarged facial pores represent a prominent and widely concerning skin condition, as well as a challenging issue in skin care. The unique structure of pores provides a favourable habitat for microorganisms. Consequently, it is of great significance to explore the relationship between pore size, skin microbiota and their microenvironment. This study is the first to investigate the correlations between pore area, skin physiological and microbiota characteristics, providing a theoretical basis for the care of skin with enlarged pores. Based on VISIA CR photographs, 199 women aged 18-35 years living in Shanghai were enrolled and categorized into four groups (P1, P2, P3 and P4) according to pore area, ranging from the smallest (P1) to the largest (P4). Non-invasive biophysical techniques and 16S rRNA high-throughput sequencing were employed to analyse facial skin physiological parameters and skin microbiome, respectively. As facial pore size increased, trans-epidermal water loss (TEWL), haemoglobin and melanin levels increased significantly, whereas skin elasticity decreased. Sebum exhibited an increasing trend, with the P4 group showing significantly higher sebum than the P2 group. Alpha diversity, as assessed by the Shannon index, decreased significantly as pore size increased, suggesting that enlarged pores may be closely associated with skin microbiome dysbiosis. Furthermore, with increasing pore size, the abundance of Cutibacterium increased significantly, whereas those of Pseudomonas, Streptococcus and Rhodococcus decreased. Correlation analysis of skin physiological parameters revealed that sebum was positively associated with TEWL, haemoglobin, and a value. Meanwhile, the abundance of Cutibacterium was significantly positively correlated with sebum, haemoglobin and a value. Correlation network analysis of skin microbial communities indicated significantly different correlation patterns for P1 and P4. Collectively, these findings suggest that sebum and Cutibacterium abundance play critical roles in regulating pore size. Enlarged pores were associated with excessive sebum production, reduced skin elasticity and increased TEWL, indicative of compromised skin barrier function. Furthermore, pore size significantly modulated the structure of the local skin microbiome, as regions with different pore sizes exhibited marked disparities in microbial diversity and abundance. These findings highlight the potential role of skin microbiome dysbiosis in the pathogenesis of pore enlargement.
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7. Directional analysis of upper eyelid wrinkles and a quantitative index for periorbital ageing.
PMID:日期:2026-09-10Periorbital ageing, manifested by wrinkles, exerts significant influence on perceived age and attractiveness, making this a primary target for anti-ageing interventions. Previous quantitative assessments of periorbital ageing have predominantly focused on the number or depth of wrinkles. In this study, we aimed to develop a novel approach to quantify age-related changes in the orientation of wrinkles on the upper eyelids. This longitudinal study (2010-2019) involved 87 healthy Japanese women (aged 22-62 years) with up to nine time points. Facial images were captured by the VISIA-Evolution system and expert-rated wrinkle scores were generated for multiple facial regions. Images of the left upper eyelid were analysed by morphological opening to decompose the wrinkle line segments into six directions (0° to 150° from vertical). We then defined a wrinkle dominance index (WDI) for each direction and investigated its association with age and expert-rated wrinkle scores. Of the six directions, only the 60° WDI showed an evident age-related increase (r = 0.58, 95% confidence interval [CI]: 0.51-0.64); furthermore, this trend accelerated after 40 years of age. Participants ≥ 40 years of age with higher 60° WDI values exhibited significantly higher expert-rated wrinkle scores for the right lateral periorbital area (p < 0.05) and lower eyelids (p < 0.05) after adjusting for age. No significant associations were identified for non-periorbital facial regions. The 60° WDI of the upper eyelid represents a quantitative indicator of periorbital ageing progression. This image-based, orientation-specific metric provides a practical tool for the objective evaluation of periorbital skin ageing in both clinical and cosmetic applications.
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8. Chaves thermal spring water formulation: Substantiating anti-ageing and anti-inflammatory effects.
PMID:日期:2026-09-10Thermal spring waters are known for their distinctive mineral compositions, which provide health-promoting, antioxidant, immunomodulatory and skin barrier-reinforcing effects. Historically valued for therapeutic use, these waters have recently gained renewed interest as active components in cosmetic and dermatological formulations. Previous works characterized one of Portugal's most renowned thermal waters from Chaves, revealing its potential as a dermatological base ingredient due to its anti-inflammatory effects, namely the reduction of interleukin-6 in stimulated human keratinocytes. In vivo assays further demonstrated improved skin barrier function, as evidenced by decreased transepidermal water loss and enhanced hydration without disturbing the skin microbiota. Building on these results, a new formulation was developed using Chaves thermal water as both solvent and active ingredient, combined with natural extracts of mallow (Malva sylvestris) and cucumber (Cucumis sativus), and the natural chelating agent sodium phytate to achieve a high natural index. This formulation was compared with the isolated thermal water to evaluate synergistic bioactivities. A formulation containing ~80% Chaves thermal spring water, Malva sylvestris and Cucumis sativus extracts and sodium phytate was prepared and characterized. Antioxidant activity (ABTS/DPPH), ferrous ion chelation and inhibition of matrix metalloproteinase-1, tyrosinase and elastase were evaluated. Anti-inflammatory effects were assessed in particulate matter-stimulated HaCaT keratinocytes by measuring interleukin-6 and interleukin-1α (Enzyme-Linked Immunosorbent Assay (ELISA)). Antimicrobial screening against Staphylococcus aureus and Staphylococcus epidermidis was performed using growth curves. This formulation was compared with the isolated thermal water to evaluate synergistic bioactivities. The results revealed a substantial increase in antioxidant capacity, as shown by enhanced ABTS radical scavenging activity and stronger inhibitory effects on ageing-related enzymes, including matrix metalloproteinase-1, tyrosinase and elastase. Anti-inflammatory activity was confirmed through reductions in both interleukin-1α and interleukin-6 levels, the former showing notable improvement compared with the thermal water. Overall, this study demonstrates that combining Chaves thermal spring water with synergistic natural extracts yields a multifunctional cosmetic ingredient with amplified antioxidant, anti-inflammatory and anti-ageing properties, offering strong potential for advanced skin care applications.
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9. Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.
9. 通过生物学知识图谱和分子对接技术对III型胶原蛋白的机制理解及肽成分筛选PMID:日期:2026-09-02Type III collagen plays a key role in maintaining skin elasticity and dermal resilience, yet its decline is associated with visible signs of skin ageing. This study aimed to establish a data-driven approach to identify cosmetic peptides with potential to enhance type III collagen through multi-target regulation. A combined strategy integrating natural language processing (NLP) and knowledge graph (KG) analysis was applied to systematically identify targets associated with type III collagen regulation. Peptides listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC) were screened based on structure-based molecular docking with multiple targets. Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models. By integrating large-scale literature mining with NLP and KG-based gene interaction analysis, we constructed a comprehensive network of genes involved in type III collagen regulation, covering processes such as collagen synthesis, degradation and extracellular matrix (ECM) organization. Based on this network, candidate peptides with predicted multi-target interactions were prioritized through structure-based screening. In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity. The combination of these peptides exhibited a greater effect than individual components. In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components. This study provides a practical framework for the identification of cosmetic peptides targeting collagen regulation. The findings support a multi-target approach and suggest that peptide combinations may enhance collagen-related outcomes relevant to skin ageing applications.
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10. Surface tension-induced mechanotransduction in keratinocytes influences fibroblast activity and dermal matrix composition.
PMID:日期:2026-09-02Human skin is a highly dynamic organ capable of sensing and responding to mechanical stimuli through tightly regulated communication between the epidermis and dermis. Daily mechanical forces-such as stretching and compression-modulate skin structure and function via mechanotransduction pathways. Central to this process are the mechanosensitive Piezo channels, which convert mechanical tension into electrochemical signals. While the role of Piezo channels in epidermal keratinocytes has been established, it remains unclear whether mechanical tension at the skin's surface can influence deeper dermal responses. In this study, we examined whether Piezo-mediated mechanotransduction in keratinocytes affects fibroblast activity and extracellular matrix (ECM) remodelling in the dermis. We applied controlled mechanical tension to the skin surface by the application of cosmetic products on the stratum corneum and measured key features of fibroblast activity and dermal matrix composition. We showed that generating surface tension-induced mechanotransduction in keratinocytes is consistent with the activation of Piezo channels and molecular changes in markers from distinct compartments, including the epidermal protein E-cadherin and dermal ECM proteins such as fibronectin and collagen III. These alterations suggest activation of downstream signalling pathways that may influence dermal fibroblasts, leading to remodelling of key ECM proteins including fibronectin and collagen III, while elastin levels remained unchanged. Our findings support the hypothesis that mechanical cues at the epidermal level, sensed via Piezo channels, may participate in interlayer communication and be associated with ECM remodelling in the dermis, supporting the hypothesis of a potential epidermis-to-dermis mechanotransduction axis in human skin.