PATHOLOGICA病理学
PATHOLOGICA(英文缩写 PATHOLOGICA),ISSN 0031-2983,eISSN 1591-951X,中文译名:病理学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 3.500 | N/A |
| 2023 | 4.400 | Q1 |
| 2024 | 2.900 | Q2 |
| 2025 | 2.800 | Q2 |
PATHOLOGICA 最新收录文献
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1. Breast carcinoma metastasizing to an adrenocortical adenoma: a case of tumour-to-tumour metastasis.
PMID:日期:2026-04-01Tumor-to-tumor metastasis (TTM) refers to a malignant tumor metastasizing to a second, distict tumor. It is a rare phenomenon and the most common donor organs are the lung and breast. Here in, we report a case of TTM metastasis of breast carcinoma metastasizing to an adrenocortical adenoma (ACA) in a 40-year-old woman. To the best of our knowledge, this is the first case in which TTM of breast carcinoma metastasizes to an ACA.
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2. Metastatic melanoma with heterologous bone after neoadjuvant immunotherapy: diagnostic insights.
PMID:日期:2026-04-01We report a BRAF V600E-mutated cutaneous melanoma (pT3b) with nodal metastases treated with neoadjuvant anti-PD-1 therapy. Axillary lymph node dissection demonstrated residual viable melanoma intimately associated with extensive heterologous lamellar bone formation within the post-treatment tumor bed. Histologic assessment supported a melanoma-related heterologous component rather than a purely reactive stromal phenomenon, underscoring a relevant diagnostic pitfall in treated specimens. The observation also has practical implications for pathological response evaluation after neoadjuvant immunotherapy: in this case, the osseous component was integrated into the viable tumor compartment to avoid underestimation of residual disease. Overall, this case exemplifies the evolving morphobiological spectrum of melanoma in the immunotherapy era, and emphasizes that careful correlation of morphology with the clinical context remains the mainstay to avoid misinterpretation, particularly when uncommon heterologous or metaplastic patterns emerge after immune checkpoint blockade.
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3. Lymphangitic breast cancer in explanted lungs with interstitial lung disease: an unexpected finding.
PMID:日期:2026-04-01A 60-year-old woman with end-stage fibrosing interstitial lung disease (ILD) underwent bilateral lung transplantation. Systematic histological analysis of the explanted lungs revealed extensive lymphangitic carcinomatosis and hilar lymph node metastases from a previously undiagnosed breast carcinoma. Retrospective imaging review identified a suspicious mammographic finding that had not been further investigated. The patient was later diagnosed with metastatic breast cancer and passed away at 12 months post-transplant. This case emphasizes the challenging diagnosis of neoplasia in end-stage lung disease. The incidence of malignancies in explanted lungs is approximately 1.65%, with metastatic cases being extremely rare. This report underscores the importance of thorough histopathological evaluation of explant lungs, advocating for standardized examination protocols to improve the accuracy and depth of pathological diagnosis.
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4. Histological insights into sudden, unexpected death due to tuberculosis: two autopsy case reports and review of the literature.
PMID:日期:2026-04-01We report two singular cases of sudden death in which the cause was advanced tuberculosis infection. In the first case, a 24-year-old man died suddenly following massive hemoptysis due to erosion of the pulmonary vessels. The second case involved a 29-year-old man who died unexpectedly from asphyxia secondary to hemoptysis caused by fibrocavitatory tuberculosis. Toxicological screening and HIV testing were negative in both cases. Medico-legal autopsy, combined with detailed histological examination, was essential to determine the exact cause of death.
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5. Teaching with human remains: curatorship, technological innovation and ethical engagement at the Morgagni Museum of Human Anatomy.
PMID:日期:2026-04-01Medical museums are increasingly challenged to balance accessibility, educational effectiveness, and ethical responsibility, particularly when displaying human remains. Despite growing interest in digital museology, limited attention has been paid to its application in contexts involving culturally sensitive materials. This study presents a qualitative case study of the renovation of the Morgagni Museum of Human Anatomy (University of Padua), focusing on the integration of digital tools, including quick response codes, augmented reality (AR), and virtual itineraries. The project aimed to enhance accessibility and public engagement while preserving the scientific and ethical integrity of the collection. The results, based on observational data collected during guided visits and educational activities, indicate that hybrid interpretive strategies combining digital and traditional tools improve visitor engagement, support layered learning, and foster a more informed interaction with anatomical and pathological specimens. In particular, the use of AR and digital content was associated with increased student participation and enhanced observational skills. This case study demonstrates that digital technologies, when embedded within a coherent curatorial framework, can strengthen rather than diminish ethical engagement with human remains. The Morgagni Museum provides a model for the sustainable and responsible reinterpretation of historical medical collections in contemporary educational contexts.
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6. Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study.
PMID:日期:2026-04-01Next generation sequencing (NGS) impacted on clinical algorithm of solid tumor patients. A heterogeneous series of NGS platforms have been implemented in clinical practice but challenging handling procedures, high technical costs, and scant affordability on sequencing diagnostic routine specimens can leave behind some patients who could benefit from target drugs. Here, we sought to evaluate technical feasibility of Oxford Nanopore Technologies (ONT) sequencing accurate identification of tumor-associated molecular alterations, in a pilot series of real-world samples. We developed a technical workflow adapting the SiRe® NGS panel, originally designed for Ion semiconductor sequencing, on MinION platform (Oxford nanopore technologies), a portable, cost effective long read sequencer. The SiRe® panel enables detection of ٥٦٨ clinically actionable somatic mutations across six key genes () relevant to targeted therapies in several solid tumors. We implemented a multiplexed assay using pooled and barcoded samples, processed on a single MinION flow cell. Performance was benchmarked from a pilot series of nine FFPE samples against Ion Torrent sequencing data. A single liquid biopsy sample was also analyzed testing accuracy of MinION technology. The adapted ONT workflow demonstrated high concordance ratei in detecting clinically relevant molecular alterations on short-read fragments, achieving comparable accuracy with standardized second generation NGS platforms on tissue and liquid biopsy samples. This proof of concept aimed to integrate ONT sequencing into molecular oncology workflows, providing practical, low-cost, and scalable alternative to conventional NGS platforms. The results support the potential of ONT technology to democratize access to precision oncology, particularly in laboratories with limited resources.
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7. Nodular fibromuscular villous stromal dysplasia (NFMVSD): forensic insights into fetal/neonatal outcomes.
PMID:日期:2026-04-01To assess the frequency, morphological features, and perinatal/forensic relevance of nodular fibromuscular villous stromal dysplasia (NFMVSD) in a large retrospective placental series. Placentas examined between 2014-2018 were retrospectively reviewed. Cases fulfilling diagnostic criteria for NFMVSD were re-evaluated macro- and microscopically, with smooth muscle actin and desmin immunostains when required. Placental weight centiles, lesion distribution, associated abnormalities, and pregnancy outcomes were recorded. NFMVSD was identified in 27 placentas (1.34%), mainly involving second-/third-order villi with multifocal nodular growth. Sixty-three percent were below the 25th weight percentile. Common findings included hypoxic distress (55%), stem vessel sclerosis (39%), and villous immaturity or dysmaturity (42%). Two intrauterine deaths (6%), four neonatal deaths (14%), and congenital anomalies (32%) occurred. NFMVSD represents a distinct placental lesion with medicolegal significance, often associated with low placental weight, vascular changes, and hypoxic features. Its recognition may help clarify unexplained fetal or neonatal deaths. Standardized criteria and multicenter studies are required to refine its clinical and forensic implications.
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8. Golden rules for optimizing the diagnostic pathway of IDH-mutant tumors: bridging evidence and clinical practice in cholangiocarcinoma and adult-type diffuse gliomas.
PMID:日期:2026-04-01Mutations in the isocitrate dehydrogenase (IDH) genes are key biomarkers in intrahepatic cholangiocarcinoma (CCA) and adult-type diffuse gliomas, although real-world adoption of comprehensive molecular diagnostics remains uneven. This review aimed to integrate published evidence, clinical experience, and international guidelines to provide pragmatic recommendations that can standardize IDH testing across healthcare systems. A multidisciplinary panel synthesized data identified through 10 PICO-driven questions, critically appraised guideline statements from ESMO, EANO, NCCN, and WHO-CNS5, and incorporated insights from clinical evidence on IDH molecular profiling in CCA patients. Recommendations were developed through interactive expert discussion. The panel addressed six issues: (i) positioning of next-generation sequencing (NGS) as a first-line assay; (ii) using liquid biopsy to supplement inadequate or uninformative tissue-based molecular analyses; (iii) tumor-adapted workflows combining immunohistochemistry, PCR, or NGS with large genomic panels; (iv) optimizing pre-analytical management of small biopsies in terms of neoplastic cell abundance and nucleic acid fragmentation to safeguard material for integrated testing; (v) evaluating promising biomarkers based on genome-wide methylation profiling and metabolic imaging in specialized centers; and (vi) novel testing strategies including centralized and decentralized algorithms. In addition, emerging approaches based on digital pathology, teleconsultation, and harmonized reimbursement pathways were discussed. These considerations were distilled into a set of "Golden Rules." Optimized molecular profiling is a cornerstone of precision oncology in IDH-mutant tumors, but the lack of harmonized procedures hinders its widespread implementation in the clinical setting. In intrahepatic CCA, upfront NGS should be prioritized to capture the full spectrum of actionable alterations, whereas in diffuse gliomas IHC for IDH1 p.R132H remains recommended, with PCR or NGS reserved for IHC-negative or equivocal cases. Advanced tools such as genome-wide methylation profiling or metabolic imaging may add value in specialized centers. The consensus-based "Golden Rules" pragmatically support harmonization of diagnostic workflows, reducing technical costs and turnaround time, and promoting equitable access to IDH-directed therapies across diverse healthcare settings.
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9. AI for cervical cancer screening on whole slide images: opportunities with open-source simple tools.
PMID:日期:2026-04-01Cervical cancer remains a major global health burden, where early detection is critical. Cytological and histological assessments aim to identify precancerous squamous intraepithelial lesions (SILs). While artificial intelligence and machine learning have shown promise, most approaches rely on cytology or are not tailored for SIL classification. The aim of this study is to develop and evaluate a weakly supervised, pixel-level machine learning framework for the histological classification of low grade and high grade SIL in whole slide images (WSIs). Specifically, we sought to assess whether an open source segmentation pipeline trained on sparsely annotated WSIs could accurately support slide-level diagnostic interpretation while minimizing annotation burden and maintaining clinical interpretability. We propose a weakly supervised machine learning framework for classifying low grade and high grade SILs in whole-slide histological images. Using Random Forest classifiers for pixel-level segmentation, the system mimics pathologists by quantifying tissue components. Training required only sparse annotations from a limited set of WSIs, yielding millions of pixel-level samples and reducing annotation burden. Applied on a test set of 309 cervical WSIs, the system achieved over 96% concordance with expert pathologists, correctly distinguishing low grade LSIL, high grade HSIL, and normal epithelium, with only one false negative and a 7-10 false positives, depending on the used model. Our approach offers accurate, interpretable, and low-cost diagnostic support, with potential for integration into routine workflows, especially in resource-limited settings.
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10. Detection of NTRK gene fusions in sarcomas: a comparative study of Pan-TRK immunohistochemistry, FISH, and RNA-Based NGS.
PMID:日期:2026-04-01Fusion involving , and are oncogenic driver occurring in several adult and pediatric tumor types. In sarcomas they are mostly found in infantile fibrosarcoma, inflammatory (IFS), inflammatory myofibroblastic tumor (IMT) and in the so-called "-rearranged spindle cell neoplasm" entity described in the current WHO (2020) classification, including lipofibromatosis-like neural tumor, fibrosarcoma-like and malignant peripheral nerve sheath tumor-like spindle cell neoplasms. We retrospectively reviewed 92 soft tissue and bone sarcomas diagnosed at the Rizzoli Institute between 2019 and 2023, in which pan-TRK IHC was performed. 17 tumours showed positive staining and were further assessed using FISH for , , and rearrangements. A subset of 12 cases underwent RNA-based NGS for fusion detection. In total, we collected data from 17 patients who tested positive for pan-TRK antibody and compared pan-TRK IHC and molecular testing for the detection of rearrangement in sarcomas. FISH analysis detected rearrangements in 4/17 cases (23.5%), while NGS confirmed fusions in 3/12 cases (25%). All fusion-positive cases confirmed by both FISH and NGS showed diffuse pan-TRK staining. Two additional cases exhibited pan-TRK diffuse positivity but were wild-type by NGS and harboured and fusions, respectively. 1 case with focal positivity by immunohistochemistry and rearrangement by FISH was not confirmed by NGS. Pan-TRK IHC can be considered an initial screening tool to identify sarcomas potentially harbouring fusions. However, the presence of diffuse pan-TRK immunoreactivity in -wild-type tumours highlights the need for cautious interpretation of IHC results. FISH may represent a useful intermediate diagnostic tool when NGS is unavailable but requires cautious interpretation particularly in cases with atypical or isolated signals. NGS-based molecular confirmation remains essential for the definitive identification of fusions.