Polish Journal of Otolaryngology波兰耳鼻咽喉科杂志
Polish Journal of Otolaryngology(英文缩写 POL J OTOLARYNGOL),ISSN 0030-6657,eISSN 2300-8423,中文译名:波兰耳鼻咽喉科杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 0.600 | N/A |
| 2023 | 1.000 | Q3 |
| 2024 | 0.600 | Q4 |
| 2025 | 0.800 | Q4 |
Polish Journal of Otolaryngology 最新收录文献
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1. Exploratory analysis of circulating miRNA-100 and its association with eosinophilia in pediatric allergic rhinitis.
PMID:日期:2026-08-04Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways characterized by a Th2-skewed immune response, elevated immunoglobulin E (IgE) levels, and eosinophilia. Increasing evidence suggests that microRNAs (miRNAs) may contribute to the regulation of immune pathways in AR; however, their role in pediatric populations remains insufficiently understood. The aim of this exploratory study was to evaluate serum expression of miRNA-100, miRNA-155, and miRNA-224 in children with AR and to assess their associations with immunological and clinical parameters. A total of 21 children were included (12 with AR and 9 non-atopic controls). Serum levels of selected miRNAs, cytokines (IL-4, IL-5, IL-6, IL-10, IL-13), eosinophil counts, and total IgE were analyzed. MiRNA-100 expression was higher in the AR group compared with controls; however, this difference did not reach statistical significance (p = 0.051). No significant differences were observed for miRNA-155 or miRNA-224. In unadjusted analyses, correlations between miRNA-100 and eosinophil parameters were not statistically significant. In partial correlation analysis adjusted for age and sex, a moderate association between miRNA-100 and absolute eosinophil count was observed (rho = 0.498; p = 0.042). Among cytokines, only IL-10 levels were significantly lower in the AR group, while a substantial proportion of measurements for other cytokines were below the detection limit, limiting interpretability. Given the small sample size and lack of statistical significance in primary comparisons, these findings should be considered preliminary and hypothesis- generating. The observed association between miRNA-100 and eosinophilia may warrant further investigation in larger, well-characterized cohorts.
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2. The role of pollen monitoring in allergology and otolaryngology: from environmental exposure assessment to personalized patient care.
PMID:日期:2026-07-21<p><strong>Introduction:</strong> Pollen monitoring plays an important role in modern allergy care.<br />Quantitatively determining airborne pollen concentrations serves as a clinically relevant<br />tool for diagnosis, treatment, disease monitoring, and prevention.<br /><strong>Aim:</strong> The study provides an overview of current clinical applications of pollen monitoring<br />in allergology and otolaryngology, and its integration with new technologies<br />that support precision medicine.<br /><strong>Methods:</strong> A narrative review of the current scientific literature was conducted, critically<br />analysing publications that connect pollen monitoring, molecular aerobiology,<br />climate change, and digital medical technologies in relation to their clinical applications<br />in allergology and otolaryngology.<br /><strong>Results:</strong> Conventional aerobiological monitoring with Hirst-type volumetric samplers<br />remains the established method for quantifying airborne pollen. It provides<br />data on the duration, intensity, and regional variation of exposure to allergenic pollen<br />from sensitising plants. Such information supports the interpretation of clinical<br />symptoms, skin test results, and molecular diagnostics. It is essential in specific<br />allergen immunotherapy, assisting with allergen selection, optimising treatment<br />courses and evaluating outcomes. These data form the basis for allergen avoidance<br />strategies, which are fundamental to prevention. Pollen monitoring also contributes<br />to otolaryngology, informing the diagnosis and treatment of inflammatory diseases<br />of the upper respiratory tract. Integrating pollen monitoring with electronic symptom<br />diaries, mobile health applications, and portable measuring devices supports<br />personalised assessment of allergen exposure and advances precision medicine. Automated<br />monitoring systems and artificial intelligence facilitate near real-time transmission<br />of information. Developments in molecular aerobiology have improved the<br />understanding of the relationship between environmental exposure and respiratory<br />symptoms. Long-term pollen monitoring provides insight into the biological impacts<br />of climate change, including changes in the timing, duration, and intensity of pollen<br />seasons, as well as the spread of invasive allergenic species.<br /><strong>Conclusions:</strong> Pollen monitoring is a clinically significant component of personalised<br />management of allergic respiratory diseases. Integration with advanced technologies<br />is expected to improve diagnostic accuracy, optimise allergen immunotherapy,<br />strengthen preventive strategies, and support the ongoing development of precision<br />medicine.</p>.
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3. Retropharyngeal and parapharyngeal abscesses in children - a 9.5-year retrospective single-center analysis followed by literature review.
PMID:日期:2026-06-19Deep neck infections are severe complications of the inflammatory processes in the upper respiratory tract. They can be divided into retropharyngeal, parapharyngeal, peritonsillar, and submandibular abscesses, depending on the affected region. Deep neck infections are considered acute bacterial complications with a progressive course and life-threatening nature, and that is why they require an immediate, broad-spectrum, intravenous antibiotic therapy. The aim of our retrospective analysis was to characterize the population of children affected by retro- and/or parapharyngeal abscesses, with special interest in clinical presentation, diagnostic tools, treatment, and potential further complications. The study was based on patients hospitalized in the Department of Pediatric Otolaryngology, Medical University of Warsaw, from January 2016 through June 2025. The clinical database was searched for records according to the ICD-10 classification, namely J39.0 or J39.1. Then, data were collected and analyzed using Microsoft Excel. A literature on this topic was also performed. We found 84 cases meeting our inclusion criteria. Clinical suspicion of an abscess/inflammatory infiltration was confirmed with contrast-enhanced CT in 82 patients. We identified 22 (31.88%) retropharyngeal and 16 (23.18%) parapharyngeal abscesses, while in 12 cases (17.4%), they coexisted. Nineteen patients (retropharyngeal [8.70%, n = 6], parapharyngeal [11.59%, n = 8], or coexisting abscesses [7.25%, n = 5]) had abscesses simultaneously in other locations: peri-tonsillar area (18.3%, n = 13) or neck abscess (8.45%, n = 6). In total, 36.21% of the CT-confirmed deep neck infections were intraoperatively classified as inflammatory infiltrations. Of the remaining 15 patients, 2 did not undergo a CT scan, and in 13, the CT scan showed pure peritonsillar abscess; all were excluded from further analysis. Finally, 69 patients were included in the final analysis. The most common complaints on admission were fever (72.46%, n = 50), restricted neck mobility (60.86%, n = 42), and neck pain (40.57%, n = 28). Other symptoms, such as trismus, dysphagia, sore throat, headache, or earache, were observed less frequently. As for the laboratory tests, 47 patients (68.11%) had elevated CRP level and 53 (76.81%) presented with elevated WBC count. PCT was measured in only 30 cases (43.47%), of which 16 (23.18%) had elevated PCT levels. Sixty-two patients underwent a drainage procedure with microbiological examination. Microbiological cultures were positive in 37 (53.62%) cases. The most frequently isolated species were , , , and . All patients were treated with ceftriaxone in combination with clindamycin or metronidazole and recovered successfully. Four patients in our group (about 5.8%) developed further complications: 2 cases of sepsis, 1 with associated central venous thrombosis; 1 case of abscess recurrence, and 1 case with long-term complication: pseudoaneurysm of the internal carotid artery. Retropharyngeal and parapharyngeal abscesses are serious complications of upper respiratory tract infections in children. Restriction of the neck mobility should always raise suspicion for this condition. Early diagnosis with prompt contrast-enhanced CT imaging when clinically indicated, together with surgical drainage and broad-spectrum intravenous antibiotic therapy, is crucial to diminish the risk of further complications. However, life-threatening complications, such as sepsis and thrombosis, may occur.
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4. Cutaneous Melanoma of the Head and Neck: Contemporary Perspectives on Diagnosis and Management.
PMID:日期:2026-06-17<p><strong>Introduction:</strong> Cutaneous melanoma of the head and neck represents a distinct subtype of cutaneous melanoma with unique epidemiological, biological, diagnostic, and therapeutic characteristics. Although it accounts for approximately one-fifth of all cutaneous melanoma cases, it occurs more frequently in older individuals, more often arises in chronically sun-exposed skin, and is associated with a worse prognosis than melanomas at other anatomical sites. This review presents current knowledge on the epidemiology, aetiology, clinical presentation, diagnosis, and treatment of cutaneous melanoma of the head and neck, with particular emphasis on the specific features of this location.</p><p><strong>Aim:</strong> The aim of this study was to present current diagnostic and treatment strategies for cutaneous melanoma of the head and neck, with particular emphasis on the unique features of this anatomical location.</p><p><strong>Methods:</strong> This article is a narrative review informed by a structured literature search. The search was conducted in PubMed/MEDLINE, Scopus, and Web of Science, covering publications from January 2014 to March 2026.</p><p><strong>Results:</strong> Chronic ultraviolet radiation exposure remains the main aetiological factor, acting in conjunction with genetic predisposition and host phenotypic traits. The clinical presentation is diverse and includes both classic pigmented lesions and nodular, amelanotic, and lentigo maligna subtypes, with the latter being particularly common in chronically sun-damaged skin. Diagnosis requires an integrated approach involving clinical examination, dermoscopy, appropriately planned biopsy, and histopathological assessment, with selected cases also benefiting from non-invasive techniques, imaging studies, molecular diagnostics, and artificial intelligence-based tools. Sentinel lymph node biopsy remains a key component of regional staging. Surgical excision is the cornerstone of local treatment, although resection margins in this region often need to be individualised because of functional and aesthetic considerations. In recent years, systemic treatment, especially immunotherapy and targeted therapy, has gained major importance and has significantly improved outcomes in both the adjuvant and advanced disease settings.</p><p><strong>Conclusions:</strong> Cutaneous melanoma of the head and neck requires multidisciplinary and individualised management, and improved prognosis depends on early diagnosis, accurate staging, and the appropriate use of modern therapeutic strategies.</p>.
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5. Genetic mutations in neuroendocrine carcinomas of unknown primary.
PMID:日期:2026-06-16<p><strong>Introduction: </strong>Although genetic mutations have been reported in neuroendocrine carcinomas of unknown primary (NECs-UP), no scientifically validated targeted therapies are currently available. Moreover, cancer genomic profiling tests remain underutilized in clinical practice. These issues highlight the urgent need to elucidate the genomic landscape of NECs-UP and its potential therapeutic relevance.</p><p><strong>Aim:</strong> This study aimed to characterize the mutational profile of recurrent and/or metastatic NEC-UP.</p><p><strong>Materials and methods: </strong>Data were analyzed for 122 consecutive patients with NECs-UP registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and August 2025. Genetic mutations were determined by next-generation sequencing. Survival of patients was determined by log-rank test and a Cox proportional hazards model.</p><p><strong>Results: </strong>The top 10 mutations in NECs-UP were <em>TP<sub>53</sub></em> (71.3%), <em>RB<sub>1</sub></em> (49.2%), <em>KMT<sub>2</sub>D</em> (24.6%),<em> NOTCH<sub>1</sub></em> (20.5%), <em>CDKN<sub>2</sub>A</em> (18.0%), <em>SPEN</em> (15.6%), <em>ARID<sub>1</sub>A</em> (15.6%), RICTOR (15.6%), <em>CIC</em> (14.8%), <em>SDHA</em> (14.8%), with 16.3 7.1 (mean SD) mutations/individual. Mutation in TP53 (p = 0.0474) and CIC (p = 0.0322) were associated with a significantly worse prognosis, as determined by log-rank test. The hazard ratios for cases with this mutation was 2.0550 (95% CI, 1.0540-4.006, p = 0.03455) for <em>CIC</em>.</p><p><strong>Conclusions: </strong>This study delineated the mutational spectrum of recurrent and/or metastatic NECs-UP. Even in advanced disease, prognostically relevant mutations were identified, emphasizing the clinical importance of cancer genomic profiling tests.</p>.
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6. Diagnostic Accuracy of Fine-Needle Aspiration Cytology in Salivary Gland Tumors: A 1331-Patient Multicenter Analysis of Institutional Variability and Size-Dependent Pitfalls.
PMID:日期:2026-06-01<p><strong>Introduction:</strong> Fine-needle aspiration cytology (FNAC) is a standard preoperative diagnostic tool for salivary gland tumors, yet its sensitivity is widely debated.</p><p><strong>Aim:</strong> This study evaluates the diagnostic accuracy of FNAC compared to final histopathology, with a specific focus on institutional variability and the influence of tumor size on diagnostic yield.</p><p><strong>Methods:</strong> A retrospective, multicenter analysis was conducted on 1331 patients who underwent surgical resection for salivary gland tumors across five tertiary centers. After excluding incomplete records, 1031 patients with informative FNAC results were analyzed. Diagnostic performance (sensitivity, specificity, accuracy, and likelihood ratios) was calculated by comparing preoperative cytology with final histopathology. Statistical evaluations (Chi-square, Welch's t-test) assessed the impact of patient demographics, tumor dimensions (4 cm), and institutional location on diagnostic concordance.</p><p><strong>Results:</strong> The overall diagnostic accuracy of FNAC was 94.1%. The procedure demonstrated excellent specificity (98.4%) but suboptimal sensitivity (50.0%), confirming a high false-negative rate. Significant institutional variability was observed (p &lt; 0.001), with local sensitivities ranging from 16.7% to 69.2%. Tumor size significantly impacted diagnostic accuracy (p = 0.0258), peaking in intermediate lesions (2-4 cm; 95.0%) but declining in both smaller (&lt;2 cm; 93.7%) and larger&nbsp;neoplasms (&gt;4 cm; 91.9%). An independent review of 298 initially non-diagnostic aspirates revealed a substantial subset of histologically confirmed malignancies, demonstrating that non-informative cytological smears cannot be assumed benign.</p><p><strong>Conclusions:</strong> While FNAC provides highly specific evidence for salivary gland malignancies, its low sensitivity and susceptibility to institutional and size-dependent variables limit its reliability in ruling out cancer. High false-negative rates, particularly in tumors exceeding 4 cm, necessitate a multimodal diagnostic approach. Integrating core needle biopsy for challenging lesions and intraoperative frozen section analysis is crucial to mitigate cytopathological limitations and ensure appropriate surgical management.</p>.
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7. Acoustic analysis and self-assessment of changes in the voice after thyroidectomy.
PMID:日期:2026-06-01A patient's voice, after a thyroidectomy uncomplicated by recurrent laryngeal nerve damage, may undergo both objective and subjective changes. The intensity and duration of these changes are unclear. The aim of this study was to conduct a subjective and acoustic analysis of the voice in patients after a thyroidectomy uncomplicated by recurrent laryngeal nerve damage. A prospective study was performed at an endocrinological surgery clinic in Poland between 2018 and 2019. The study included 70 patients who had undergone a thyroidectomy due to noncancerous goitre. The Voice Handicap Index was used for a subjective assessment of the voice. An acoustic analysis was performed using the DiagnoScope Specjalista software, designed for a comprehensive assessment of the voice. A three-stage laryngological examination was performed. The mean age of the participants was 53 years (71% women and 29% men). Most of the patients (80.0%) subjectively assessed their vocal impairment as minor, 18.6% as moderate and 1.4% as severe. The patients assessed the physical state of their voice as the worst. The short-term parameters obtained through an acoustic analysis differed significantly between the subsequent measurements and were worst on the second day after the operation. The changes subsided six months after the operation. Likewise, a significant improvement in the long-term parameters was observed six months after the operation; specifically, the phonation time (15.11 vs 12.64 vs16.14) and the performance index (7.91 vs 6.50 vs 9.04). No significant changes were observed between each measurement in terms of the no phonation index, breaks in phonation index and the F0 modulation index. Voice impairment after a thyroidectomy is frequent, according to a subjective assessment, and has been confirmed by an acoustic analysis of the short- and long-term parameters of the voice. These changes usually subside six months after the operation. Some patients require logopaedic support to normalise their voice emission technique.
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8. Genetic mutations in metastatic adenocarcinoma of unknown primary.
PMID:日期:2026-06-01Although several genomic alterations have been reported in adenocarcinoma of unknown primary (ACUP), molecularly targeted therapies are not yet clinically established, and comprehensive genomic profiling (CGP) is rarely used in daily practice. We aimed to clarify the molecular landscape and prognostic impact of key mutations in recurrent or metastatic ACUP. Data from 480 consecutive ACUP patients registered in Japan's National Cancer Center (C-CAT) between June 2019 and August 2025 were analyzed. Somatic mutations were identified using the FoundationOne CDx platform. Overall survival (OS) was assessed by Kaplan-Meier analysis, log-rank tests, and multivariate Cox proportional hazards modeling. The most frequent alterations were TP53 (59.4%), KRAS (31.5%), CDKN2A (26.3%), KMT2D (22.3%), LTK (17.9%), NOTCH3 (16.9%), STK11 (16.3%), CDKN2B (15.8%), ERBB2 (15.4%), and GNAS (15.2%). Patients harbored an average of 17.3 9.9 mutations. Mutations in GNAS (p = 0.046) and PIK3CA (p = 0.025) were associated with better OS, whereas ARID1A (p = 0.049) and NOTCH1 (p = 0.038) predicted worse OS. In Cox analysis, hazard ratios (HR [95% CI]) were 0.57 (0.36-0.92, p = 0.020) for GNAS, 0.57 (0.33-0.96, p = 0.033) for PIK3CA, 1.98 (1.27-3.09, p = 0.0024) for ARID1A, and 1.84 (1.17-2.91, p = 0.0090) for NOTCH1. GNAS and PIK3CA mutations were linked to favorable outcomes, while ARID1A and NOTCH1 alterations indicated poor prognosis in ACUP. These results highlight the prognostic significance of specific genomic alterations and support integrating CGP into the clinical management of ACUP.
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9. ASMR Through the Eyes of the Public: Opinions on Its Possible Therapeutic Role.
9. 公众眼中的ASMR：对其可能治疗作用的看法PMID:日期:2026-05-26<p><strong>Introduction:</strong> Autonomous Sensory Meridian Response (ASMR) is a phenomenon characterized by the occurrence of specific somatic and emotional sensations induced by audiovisual stimuli. Despite the growing popularity of ASMR on social media and reports of its potential relaxation-related effects, there is a lack of conclusive data supporting its use as a therapeutic tool.</p><p><strong>Aim:</strong> This study aimed to assess social awareness of ASMR, characterize the demographic profile of its users, and estimate the therapeutic potential of ASMR in the context of social perception of this method and the declared willingness to use it.</p><p><strong>Material and methods: </strong>The study was exploratory and conducted using an anonymous online questionnaire among 203 respondents of diverse ages, sexes, and educational backgrounds. The analysis included familiarity with ASMR, patterns and frequency of ASMR content use, preferred sensory stimuli, subjective emotional responses, and attitudes toward the potential use of ASMR in therapy.</p><p><strong>Results:</strong> The results demonstrated that ASMR is mainly known among individuals under 30 years of age and is primarily used for entertainment and relaxation. At the same time, a significant proportion of respondents reported neutral or negative reactions, and more than half did not express a willingness to use ASMR as a therapeutic method.</p><p><strong>Conclusions:</strong> The obtained results indicate that ASMR remains a phenomenon with limited acceptance as a therapeutic tool, and its potential clinical application requires further research into its mechanisms of action, safety, and individual differences in sensory processing.</p>.
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10. Leveraging large language models to audit perioperative total laryngectomy care: anesthetic, nutritional, and complication profiles in a real‑world cohort.
PMID:日期:2026-05-25<p><strong>Introduction: </strong>Total laryngectomy (TL) remains the standard treatment for advanced la‑ ryngeal cancer, and its perioperative management requires close collaboration within a multidisciplinary team, including anaesthesiologists and clinical nutritionists.</p><p><strong>Aim:</strong> The aim of this study was to analyse the perioperative course of patients un‑ dergoing TL from both an anaesthesiologist's and a nutritionist's perspective, with a particular focus on the feasibility and performance of structured data extraction from electronic medical records using large language models (LLMs).</p><p><strong>Material and methods:</strong> We performed a single‑centre retrospective analysis of 43 consecutive patients undergoing TL (ICD‑9 codes 30.32, 30.39, 30.41, 30.49) be‑ tween January 2024 and April 2026. Clinical data, including physician notes (n = 845), nursing notes (n = 2578), discharge summaries (n = 173), and consultations (n = 123), were subjected to structured extraction using large language models (gemma-3-31Bit/gemma-4-26B-it). Demographics, tumour stage, length of stay (LOS), periopera‑ tive nutrition, pharmacotherapy, postoperative complications, temporal laboratory trends, and rehabilitation were analysed.</p><p><strong>Results: </strong>The cohort comprised 35 men (81%) and 8 women (19%), with a mean age of 66.4 9.8 years; pT4a (49%) and pN0 (82%) predominated. Median LOS was 15.0 days (IQR 13.1-16.5). Enteral nutrition via nasogastric tube was used in 95% of patients, and oral intake was initiated at a median of postoperative day 13. Multimodal anal‑ gesia based on intravenous paracetamol (60%), ketoprofen (47%), and metamizole (40%) was routinely employed, while strong opioids were used in only 5% of pa‑ tients. Postoperative complications occurred in 22.5% of cases, with pharyngocuta‑ neous fistula (PCF) being the most frequent (12.5%). In‑hospital mortality was 0%, and overall mortality during a median 12‑month follow‑up was 2.3%. CRP peaked on postoperative day 3 (mean 114 mg/L). Pharmacologic VTE prophylaxis was admi‑ nistered in 65% of patients.</p><p><strong>Conclusions:</strong> In TL patients, enteral feeding forms the backbone of nutritional sup‑port, and multimodal analgesia provides effective pain control, whereas VTE pro‑phylaxis and other modifiable elements of perioperative care warrant optimization within prehabilitation and ERAS-based protocols.</p><p>&nbsp;</p>.