JOURNAL OF COMPARATIVE PATHOLOGY比较病理学杂志
JOURNAL OF COMPARATIVE PATHOLOGY(英文缩写 J COMP PATHOL),ISSN 0021-9975,eISSN 1532-3129,中文译名:比较病理学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.083 | Q3 |
| 2022 | 0.800 | Q3 |
| 2023 | 0.800 | Q3 |
| 2024 | 0.900 | Q3 |
| 2025 | 1.200 | Q3 |
JOURNAL OF COMPARATIVE PATHOLOGY 最新收录文献
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1. Immunohistochemical investigation of the stem cell landscape of canine prostate cancer.
PMID:日期:2026-09-17Prostate cancer is aggressive in dogs and characterized by limited therapeutic responsiveness and a poor prognosis. While cancer stem cells (CSCs) are increasingly recognized as key drivers of tumour progression, therapeutic resistance and metastasis in human prostate cancer, their role in canine prostate cancer remains poorly defined. This study aimed to characterize the expression of stem cell-associated markers in canine prostatic adenocarcinoma by assessing a broad panel of CSC-associated markers in primary prostate tissues. Immunohistochemistry evaluated the expression and subcellular localization of seven CSC-associated markers (CD44, CD133, Nanog, Nestin, Oct3/4, Sox2 and Trop2) in non-neoplastic canine prostate samples and prostatic adenocarcinoma cases. Marker expression was semiquantitatively assessed and differences between groups analysed using non-parametric statistical tests. Neoplastic prostatic tissue demonstrated significantly increased immunolabelling of CD44, CD133, Nanog (nuclear and cytoplasmic), Nestin (nuclear and cytoplasmic), Oct3/4 (cytoplasmic), Sox2 (cytoplasmic) and Trop2 compared with non-neoplastic prostate tissue (P <0.05). In contrast, nuclear Oct3/4 and nuclear Sox2 immunolabelling did not differ significantly between groups. Distinct patterns of nuclear and cytoplasmic localization were observed for several markers, suggesting context-dependent regulation and potential functional heterogeneity within CSC-like populations. These findings demonstrate that canine prostatic adenocarcinomas have multiple stem cell-associated markers, consistent with the presence of a stemness-associated phenotype within these tumours.
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2. Evaluation of cyclin-dependent kinase 4 immunolabelling and a germline p.G201S variant as predictors of clinical outcome in canine mammary tumours: a preliminary study.
PMID:日期:2026-09-09Cyclin-dependent kinase 4 (CDK4), a regulator of the G1/S transition, is frequently dysregulated in cancer. Although extensively studied in human breast cancer, its significance in canine mammary tumours remains poorly understood. This preliminary study investigated the prognostic value of CDK4 immunohistochemistry (IHC) and of sequence variation in the CDK4 kinase-domain segment surrounding residue 201. Thirty-three prospectively enrolled female dogs with tumours affecting a single mammary chain underwent unilateral radical mastectomy. An 89-bp CDK4 segment was sequenced and paired with CDK4 and oestrogen receptor (ER) IHC and clinicopathological follow-up. Thirty dogs (11 deaths) entered the primary analyses (three were suboptimal). Missense variant c.601G > A (p.G201S) was identified in seven of 30 dogs (23%; allele frequency 15%) but not associated with any clinicopathological variable or survival (hazard ratio [HR] 1.54, 95% confidence interval [CI] 0.39-6.00). CDK4 immunolabelling was associated with ER immunolabelling (odds ratio 8.75, 95% CI 1.21-63.4; P = 0.058). CDK4 immunolabelling was not associated with survival (HR 2.73, 95% CI 0.78-9.48; P = 0.11); after adjustment for advanced stage, it reached only borderline significance (HR 3.92, 95% CI 1.01-15.2; P = 0.048), but this did not survive a worst-case sensitivity analysis. The 12-month time-dependent receiver operating characteristic area was 0.79 (95% CI 0.56-0.96) and the negative predictive value (NPV) 93%. p.G201S most likely represents a common germline polymorphism rather than a driver event. CDK4 immunolabelling tracked the ER-positive phenotype but was not an independent prognostic marker; its high short-term NPV suggests a rule-out tool requiring validation in a larger cohort.
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3. Renal thrombotic microangiopathy with membranoproliferative glomerular remodelling in a Japanese Black steer.
PMID:日期:2026-09-05Detailed clinicopathological and ultrastructural characterizations of bovine renal thrombotic microangiopathy (TMA) remain limited. A 20-month-old castrated Japanese Black (Bos primigenius taurus) steer was presented with depression and severe azotaemia. Histologically, glomeruli varied considerably in size, with many being reduced in size and collapsed or with global sclerosis, whereas enlarged glomeruli were less frequent. Intraglomerular thrombi consisted predominantly of periodic acid-Schiff-positive hyaline material, while fibrin-positive thrombi were infrequent. Small arteries and arterioles had concentric wall thickening with marked narrowing of the lumina, and similar vascular lesions were observed in the jejunal submucosa also. Ultrastructurally, glomerular capillaries showed severe narrowing of the lumina, accompanied by frequent mesangial interposition and multilayering of the glomerular basement membrane. No electron-dense immune deposits were identified. These findings were consistent with subacute-to-chronic endothelial injury-associated TMA with membranoproliferative remodelling. This case provides a comprehensive clinicopathological and ultrastructural characterization of bovine renal TMA.
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4. Pathological aspects of an amebiasis outbreak in captive testudines.
PMID:日期:2026-08-01Amebiasis is a parasitic disease primarily associated with amoeboid protozoa of the genus Entamoeba; however, comparable infections may also be caused by other genera in different hosts. In reptiles, it is mainly attributed to Entamoeba invadens, which can be fatal in several species. This report describes an outbreak of amebiasis in two species of testudines, red-footed tortoises (Chelonoidis carbonarius) and black-bellied sliders (Trachemys dorbigni), from a wildlife screening and rehabilitation centre in Minas Gerais, Brazil. The facility housed around 130 testudines, and between 2022 and 2024, 79 animals died, of which 21 were diagnosed with amebiasis based on post-mortem examination. Clinical signs were non-specific, including anorexia, lethargy, reluctance to move and sudden death. Histological lesions were most frequent in the liver (17/21), duodenum (10/21) and colon (4/21), but were also present in the coelomic wall (4/21), lungs (2/21) and spleen (1/21). Lesions were characterized by necrosis, fibrin deposition and inflammatory infiltrates of lymphocytes and histiocytes, associated with numerous intralesional amoeboid protozoa. For diagnostic confirmation and species-level identification, polymerase chain reaction was performed on frozen tissues from six animals, targeting the amplification of a 109 bp fragment of the E. invadens 18S rRNA gene. Based on the pathological and molecular findings, along with protozoan species identification, a definitive diagnosis was established. Although amebiasis has been reported previously in reptiles, including red-footed tortoises, this is the first description in black-bellied sliders. This study highlights the importance of amebiasis as a cause of morbidity and mortality in captive testudines.
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5. Tympanic papillary adenoma (tympanic papilloma) in a cat - a case report.
PMID:日期:2026-08-01A 9-year-old cat presented with an inflammatory discharge and a polypoid mass located in the left ear canal, penetrating the tympanic membrane. The polypoid mass was removed surgically using traction-avulsion but not submitted for histological examination. Subsequently, the cat underwent computed tomography of the head, which revealed an irregular mass located in the left tympanic bulla. The mass was resected surgically during external ear canal ablation, with lateral osteotomy of the tympanic bulla, and submitted for histological examination. The tumour consisted of papillary structures lined by a single layer of cylindrical, ciliated cells with basally oriented, oval nuclei, minimal atypia, very low mitotic count and periodic acid-Schiff-positive mucin within the cytoplasm. The tumour cells immunolabelled for cytokeratins, and the Ki67 index was 10.4. Based on these findings, tympanic papillary adenoma was diagnosed. Although the clinical signs initially resolved after surgery, the tumour recurred within 17 months, as confirmed by histological examination. The recurred tumour showed an increased mitotic count and Ki67 index (18.6) compared with the primary tumour. This case report presents the clinical outcome, radiological and histological features of tympanic papillary adenoma in a cat, a very rare entity with no direct analogue in human pathology.
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6. Unilateral plantigrade stance in piglets associated with chronic neuritis following intramuscular medication.
PMID:日期:2026-08-01Locomotor disorders in pigs involve both infectious and non-infectious causes; however, iatrogenic peripheral neuropathies are rare. This study describes clinical, macroscopic and histological alterations associated with an outbreak of chronic neuritis in piglets following intramuscular drug administration on two farms. In two farms, each with 500 sows, approximately 7% of farrowing house piglets (26/370) presented with a plantigrade posture of the left pelvic limb (LPL) beginning on the third day of life, with no clinical improvement despite treatment. Nine piglets were subjected to necropsy. On gross examination, an off-white thickening involving the branches of the common fibular nerve of the LPL (indicative of fibrosis) was observed. On microscopic examination, Masson's trichrome and haematoxylin and eosin staining revealed granulomatous inflammation and abundant fibrovascular connective tissue between nerve fascicles, many of which were atrophied or undergoing degeneration. The anatomopathological findings were consistent with chronic (22.2%) and chronic-active (77.8%) neuritis and perineuritis associated with denervation-induced muscular atrophy, predominantly affecting the gastrocnemius muscle, which resulted in the plantigrade posture. Considering the location and pattern of the histological lesions, as well as the history of intramuscular injections during the first days of life, the lesions were considered to be of iatrogenic aetiology.
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7. Congenital segmental absence of tracheal cartilaginous rings in two cats.
PMID:日期:2026-08-01Tracheal disorders are uncommon in animals. Among congenital anomalies, segmental or complete absence of tracheal rings is described rarely in humans and in animals even less frequently. This report describes the clinical, gross and histopathological features of two cases of segmental absence of tracheal rings in cats and briefly reviews tracheal disorders. Cat 1 was a 1-year-old male mixed breed (Domestic Shorthair) that presented with a history of trauma and pneumothorax, followed by persistent respiratory distress and death despite treatment. Cat 2 was a 3-year-old male stray mixed breed (Domestic Shorthair) admitted with severe dyspnoea that died before therapy could be initiated. At necropsy, both cats showed an absence of cartilaginous rings in the distal third of the trachea, approximately 2 cm cranial to the carina. The affected segments measured 1 cm (cat 1) and 2 cm (cat 2) in length, with moderate to marked narrowing of the lumina. Cat 1 also had marked emphysema in the perirenal adipose tissue. Histologically, the cartilaginous rings were completely absent and replaced by vascularized fibrous connective tissue infiltrated by a small number of mixed inflammatory cells and loss of the respiratory epithelium in the affected segments. Pulmonary lesions included alveolar emphysema, congestion, haemorrhage and oedema in cat 1, and atelectasis, congestion and alveolar oedema in cat 2. Segmental absence of tracheal rings in cats appears to occur predominantly in the distal third of the trachea. Although rare, it should be considered as a differential diagnosis in cats presenting with respiratory distress.
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8. Giant paraovarian cyst causing abdominal distention in a Swiss mouse (Musmusculus).
PMID:日期:2026-08-01A 9-month-old unsterilized female Swiss mouse (Mus musculus), housed in the Central Animal Facility of the Federal University of Mato Grosso, presented with a 1-month history of progressive abdominal distention. Occupying most of the abdominal cavity was a prominent oval-shaped, 30 g (constituting 38% of the bodyweight), 4.5 cm × 3.5 cm × 3.2 cm nodule with an irregular surface that was compressing the liver, diaphragm and thoracic cavity cranially, the right kidney laterally and the intestinal loops caudally. Histological examination confirmed a multilocular paraovarian cyst closely resembling the giant paraovarian cysts described in women. Paraovarian cysts should be suspected as a differential diagnosis in cases of marked abdominal distention in mice.
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9. Do we agree on counting mitotic figures in cytology of canine lymphoma? Three field selection methodologies by three observers.
PMID:日期:2026-08-01Mitotic count is a key parameter of the cytological evaluation of canine lymphomas (CLs), but consensual guidelines for counting are missing. Variations in cell preservation are common in cytological smears and this can compromise the reproducibility of mitotic counting. We compared three methodologies for selecting fields for mitotic counting in CL cytological smears and interobserver agreement was assessed. Mitotic counting was performed in 19 CLs by three observers in five high-power fields (HPFs), selected according to the following methodologies: (A) randomly and with well-preserved cells; (B) adjacent fields within the best-preserved monolayer area; and (C) in the area with the highest mitotic activity (hot spots). Counts were analysed both as the total number in five HPFs and as number per mm; using published cut-off values, mitotic counts were classified as low, intermediate or high. Counts by methods A and B were comparable, while consistently higher values were obtained with method C. Overall, the mitotic count classification shifted in 21% of the cases, with a higher assignment of cases to the high category using method C. Interobserver agreement was poor between observers using microscopes with different field of view diameters. When counts were normalized to number per mm, the agreement improved. The methodology of counting in adjacent fields showed better interobserver agreement compared to random fields. However, there was a high variability in the recorded numbers by each observer in highly proliferative CLs. The data highlights that mitotic counts in cytological smears of CL are highly dependent on methodology for selection of the fields and on the microscope.
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10. A retrospective study (2006-2020) of biopsy cases in pet guinea pigs (Cavia porcellus), degus (Octodon degus) and chinchillas (Chinchilla lanigera) at an exotic animal clinic in Tokyo, Japan.
PMID:日期:2026-08-01Hystricomorphs, such as guinea pigs (Cavia porcellus), degus (Octodon degus) and chinchillas (Chinchilla lanigera), have become increasingly popular pet animals in Japan. However, comprehensive data on diseases in these animals remain limited, primarily restricted to single case reports, except for guinea pigs. The present study aimed to investigate the frequency of neoplastic and non-neoplastic diseases in pet guinea pigs, degus and chinchillas in Japan and to describe their epidemiological characteristics. We reviewed biopsy samples from guinea pigs (n = 134), degus (n = 57) and chinchillas (n = 16) collected at the Miwa Exotic Animal Hospital and the Laboratory of Veterinary Pathology, University of Tokyo, between 2006 and 2020. The most common condition in guinea pigs was integumentary disorders (n = 83; 61.9%), with mammary carcinoma (n = 41; 49.1%) being the most prevalent. The second most common condition was female reproductive disorders (n = 43; 32.1%), with ovarian cysts (n = 11; 25.6%) the most frequent. In degu samples integumentary disorders (n = 23; 40.3%) were the most common, followed by respiratory disorders (n = 22; 38.5%). Soft tissue sarcoma (n = 15; 65.2%) was the most frequently observed integumentary disorder, while fibroma with bone formation (n = 10; 45.4%) was the most prevalent respiratory disorder. In chinchilla samples female reproductive disorders (n = 13; 81.2%) were the most common, with endometritis being the most frequent (n = 5; 38.4%). The frequency of disorders peaked at 3-4 years old in guinea pigs and degus. No age-specific peaks were observed in chinchillas. This is the largest retrospective histopathological study on degus and chinchillas to date and the findings provide valuable insights for veterinarians treating hystricomorphs.