BEHAVIOR GENETICS行为遗传学
BEHAVIOR GENETICS(英文缩写 BEHAV GENET),ISSN 0001-8244,eISSN 1573-3297,中文译名:行为遗传学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.965 | Q2 |
| 2022 | 2.600 | Q2 |
| 2023 | 2.600 | Q2 |
| 2024 | 2.200 | Q2 |
| 2025 | 2.400 | Q2 |
BEHAVIOR GENETICS 最新收录文献
-
2. Genetics of Educational Attainment and Childhood Problem Behavior: Direct Genetic Effects, Cognitive Pathways, and Sex Differences.
2. 教育成就与儿童问题行为的遗传学：直接遗传效应、认知路径与性别差异PMID:日期:2026-09-16We examined the genetic underpinnings of problem behavior in children and adolescents (4-17 years old) by leveraging a within-family trio design using data of European ancestry from the Lifelines cohort (N=3,160-4,611). We estimated direct genetic effects of educational attainment (EA) polygenic indices (PGIs), as a whole and decomposed into cognitive (Cog) and non-cognitive (NonCog) components via GWAS-by-subtraction, on a comprehensive set of internalizing and externalizing behaviors assessed via self- and parental report Achenbach System of Empirically Based Assessment (ASEBA) measures. We found that higher EA PGIs, particularly their Cog component, were robustly associated with lower levels of Attention Problems and Somatic Complaints, in parental and self-report samples respectively. These associations persisted after adjusting for parental PGIs, supporting a causal interpretation under counterfactual reasoning. In contrast, the NonCog EA PGI showed weaker and less consistent associations with problem behavior, though we cannot rule out that this reflects limited power to detect smaller effects. We observed pronounced sex differences, with associations largely driven by girls, for whom the Cog component was the primary predictor. In the self-report sample in particular, associations with Somatic Complaints were significantly stronger in girls, with no significant findings observed for boys. We also found that associations with Somatic Complaints were significantly larger in the self-report than the parental report sample, while for other scales, differences across informants were statistically negligible. Our findings contribute to a more holistic understanding of how EA-related genetics manifest in socioemotional processes beyond academic achievement.
-
3. Behavioral Genetics as a Public Science: Introduction to the Special Issue.
3. 作为公共科学的行为遗传学：特刊简介PMID:日期:2026-09-05该文献暂无摘要。
-
4. Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism.
PMID:日期:2026-08-27Autism is a neurodevelopmental disorder with a significant male prevalence bias. While recent evidence suggests that genetic heterogeneity is indexed by age at diagnosis, males are also typically diagnosed earlier, such that the extent to which these age-specific findings are confounded by shared genetic signal with sex-specific genetic architecture remains unclear. To test this, we leveraged sex- and age of diagnosis-stratified GWAS summary statistics for autism and applied a multiple regression framework within Genomic Structural Equation Modeling (Genomic SEM). This approach allowed us to disentangle the overlapping genetic variance between sex, diagnostic timing, and 68 clinically relevant phenotypes reflecting a host of different psychiatric, cognitive, health, and social outcomes. Consistent with prior findings, we identified significantly divergent genetic associations with external traits between early- and late-diagnosed autism subtypes. We also identified few findings for sex-specific associations, along with high genetic correlations across these two traits, which questions the biological basis for disproportionate prevalence rates in males. Multiple regression models confirmed that early-specific associations were not confounded by biological sex. Conversely, the correlations between late-diagnosed autism and the sex-stratified autism GWAS were near 1, indicating that late-specific associations may be confounded. Follow-up analyses using an internalizing factor provided support for sex differences in clinical presentation and age at diagnosis, with female-diagnosed and late-diagnosed autism estimated to have stronger genetic correlations with internalizing traits compared to male and early-diagnosed counterparts. This study underscores the importance of subtyping in genetic analyses and provides a framework to disentangle confounded genetic pathways.
-
5. Genetic and Environmental Associations Between Depressive Symptomatology and Loneliness in Adulthood.
PMID:日期:2026-08-25The conceptual and symptom overlap between depression and loneliness is so strong that depressive symptom rating scales often include measures of loneliness, and their linear association ranges between .40 and .68. Despite these findings, few genetically informed studies have investigated the genetic and environmental association between them. We tested the degree to which depressive symptomatology and loneliness are correlated genetically and environmentally, and whether the environmental correlation in men is larger than in women. In this study, we used 428 individual twins (229 MZ twins and 187 DZ twins) from 266 families (139 MZ families and 127 DZ families) from the Louisville Twin Study (M = 48.17; 56% female). Loneliness was measured using the UCLA Loneliness Scale (3 items), and depressive symptomatology was measured using the Center for iologic Studies Depression Scale. Statistical analysis included twin correlations and a correlated factors model. Results indicate that the genetic correlation between loneliness and depressive symptomatology is .47 [.95CI: .16-.78] and the nonshared environmental correlation is .28 [.95CI: .12-.43]. No sex differences were observed. In mid-adulthood, a little less than half of the genetic variance associated with depressive symptomatology is also associated with loneliness. Nonshared environmental factors underlying depressive symptomatology account for approximately 54.4% of the strong association with loneliness, too. These results are similar to bivariate estimates reported in a previous studies of young adulthood, suggesting that across adulthood, the contribution of genetic and non-shared environmental factors to the association between loneliness and depression is constant.
-
6. Selective Breeding for Voluntary Wheel-Running Behavior in Mice is not Associated with Reduced Lifetime Reproductive Success or Lifespan Under Long-Term Paired Breeding Conditions.
PMID:日期:2026-08-12We studied lifespan and lifetime reproductive success (LRS) in mice from a selection experiment that includes 4 replicate High Runner (HR) lines bred for voluntary wheel-running behavior and 4 non-selected Control (C) lines. HR mice typically run ~ threefold farther on a daily basis, leading to substantially increased energy expenditure and food consumption, and are also more active and eat more when housed without wheels. HR and C mice have been shown to differ for many other traits that could affect reproduction, including body mass and composition, aerobic capacity, hormonal profile (including corticosterone and leptin), and other behavioral traits (e.g., maternal care, thermoregulatory nesting, anxiety-like behavior in an elevated plus maze). At generation 97, male-female pairs were maintained until end of life in standard cages without wheels, with ad lib food and water. The number of pups weaned (LRS) ranged from 0-80, with a mean of 29.1 ± 8.1 (SE) for C lines and 25.8 ± 4.4 for HR (P = 0.73). Thus, artificial selection for high voluntary exercise did not significantly alter LRS. In addition, we found no statistical difference in average lifespan for dams or sires. However, replicate lines differed significantly for several traits, presumably due primarily to random genetic drift. At the level of individual variation, correlations among reproductive traits and lifespan provided little evidence for negative associations, and LRS was not negatively related to parental longevity. Overall, long-term selection on voluntary locomotor behavior did not produce detectable reductions in reproductive output or lifespan under standard laboratory conditions.
-
7. TALE and Hox Transcription Factors Modulate Adult Behaviors in Zebrafish.
PMID:日期:2026-08-07Behavioral dysfunction is a common characteristic of many neurodevelopmental and mental health disorders. While the causes of these disorders vary, aberrant behaviors may arise from alterations in transcriptional regulation during early neural development. Because transcription factors (TFs) often belong to families of closely related members, disruption of a single TF may indirectly influence the functionality of other family members. Consequently, mutations in TFs within the same family may lead to overlapping, yet distinct, phenotypes. This feature of TF function has important implications for understanding behavioral phenotypes, but detailed analyses across a single TF family are still lacking. In this study, we present a comprehensive behavioral analysis of adult zebrafish harboring mutations in individual members of the TALE and Hox TF families, that are essential for nervous system development. Using a battery of validated behavioral assays, we uncover elevated stress responses among all TF mutant lines, as well as TF-specific dysregulation in social interaction, locomotion, and endurance. The shared behavioral abnormalities across mutants suggest TF family members converge on core developmental pathways for stress-related behavioral regulation, while mutation-specific phenotypes indicate unique roles for individual TFs in fine-tuning neural function. Our findings provide a systematic behavioral characterization of TALE and Hox mutants in a vertebrate model and provide a framework for understanding how genetic variation within TF families may differentially contribute to vulnerability for neurodevelopmental and mental health disorders.
-
8. {"_":"ADHD and Student Grades in Children from the ABCD Study: A Twin and Siblings Study.","sup":["®"]}
8. {"_":"ABCD研究中儿童ADHD与学生成绩：一项双胞胎和兄弟姐妹研究。","sup":["®"]}PMID:日期:2026-07-24Attention-deficit/hyperactivity disorder (ADHD) symptoms are strongly associated with lower academic performance, yet the nature of this association remains uncertain. We analyzed data from twins and siblings in the Adolescent Brain Cognitive Development (ABCD) Study to examine the relationship between ADHD symptoms and school grades using genetically informed models. ADHD symptoms were assessed via the Child Behavior Checklist, and grades were caregiver-reported for the previous school year. Both phenotypes were modeled as ordinal variables. We applied Direction of Causation (DoC) and Mendelian randomization extensions (MR-DoC and MR-DoC2) incorporating polygenic risk scores for ADHD and educational attainment. DoC and MR-DoC comparisons did not distinguish directionality (e.g., DoC forward path estimate = - 0.16, 95% CI [- 0.26, - 0.07]; reverse path = - 0.30, 95% CI [- 0.63, - 0.17]). In MR-DoC2, estimates differed in precision: ADHD-to-grades path = - 0.31, 95% CI [- 0.62, - 0.11]; grades-to-ADHD path = - 0.60, 95% CI [- 1.20, 0.03]. Sex-limitation tests indicated no moderation by sex.
-
9. Growing Up with Parents Who Smoke: Genetic and Environmental Effects on Offspring Substance Use and Externalizing Psychopathology From a 20-Year Minnesota Study of Adoptive Families.
9. 与吸烟父母共同成长：一项为期20年的明尼苏达收养家庭研究中对后代物质使用和外化性精神病理的遗传与环境效应PMID:日期:2026-07-15[中文摘要] 为庆祝马特·麦丘（Matt McGue）的职业生涯，我们对他近二十年前指导的一项简洁而精巧的研究（Keyes等，2008）进行了纵向延伸。我们在二项收养研究中考察了青少年期暴露于父母吸烟对物质使用及外化结局的影响。共对来自617个家庭的1232名子女在平均年龄15岁、18岁、22岁和32岁时进行了纵向评估，其中37%的子女在初始评估时至少与一位吸烟的父母同住。我们在所有可用的随访评估中检验了该暴露对子女烟草和大麻使用、尼古丁依赖、酒精依赖和药物依赖，以及注意缺陷多动障碍（ADHD）、对立违抗障碍、品行障碍和成人反社会行为的影响。在收养子女中，所有结局的效应量通常较小，表明暴露于父母吸烟的环境效应极小。相比之下，在生物学子女（非收养子女）中，暴露对所有结局的效应更强，尽管并非一致地具有统计学显著性。父母吸烟的环境风险似乎特异地作用于子女的烟草使用，而遗传风险在外化结局中则更为广泛，这与Keyes等（2008）基于该队列初始评估的原始发现一致。
[英文摘要] In celebration of Matt McGue's career, we conducted a longitudinal extension of a simple and elegant study he supervised nearly two decades ago (Keyes et al. 2008). We examined the effects of teenage exposure to parental smoking on substance use and externalizing outcomes in an adoption study. In total, 1232 offspring from 617 families were longitudinally assessed at mean ages of 15, 18, 22, and 32 years, with 37% of offspring living with at least one smoking parent at the intake assessment. We tested the effect of this exposure on offspring tobacco and cannabis use; nicotine, alcohol, and drug dependence; and ADHD, oppositional defiant disorder, conduct disorder, and adult antisocial behavior at all available follow-up assessments. Effect sizes in adoptive offspring were generally small for all outcomes, indicating minimal environmental effects from exposure to parental smoking. In contrast, the effects of exposure were stronger across all outcomes for biological (nonadopted) offspring, though not uniformly significantly statistically stronger. The environmental risk of parental smoking appears specific to offspring tobacco use while the genetic risk is more general across externalizing outcomes, consistent with Keyes et al. (2008)'s original findings from the initial intake assessment of this cohort.
-
10. Genetic and Environmental Influences on Caffeine Intake in Korean Twins.
10. 遗传和环境对韩国双胞胎咖啡因摄入量的影响PMID:日期:2026-07-10Caffeine intake may be influenced by both genetic and environmental factors. This study aimed to examine the genetic contribution to variation in coffee and tea drinking, as well as total caffeine intake. A total of 1,106 Korean twins, comprising 456 monozygotic and 97 dizygotic twin pairs aged 30 years or older, from the Healthy Twin Study were included. Structural equation models were used to assess heritability estimates and their 95% confidence intervals (CIs). Heritability (95% CI) was estimated at 0.29 (0.21, 0.37) for coffee drinking, 0.11 (0.02, 0.20) for tea drinking, and 0.27 (0.16, 0.38) for total caffeine intake, with the remaining variance in each trait attributed to unique environmental factors. The unique environmental factors contributed more substantially to coffee drinking than genetic factors during early adulthood, while the genetic contribution to tea drinking remained consistently low across all ages. In conclusion, coffee drinking, tea drinking, and total caffeine intake were partly heritable, with unique environmental factors playing a predominant role.