CD14在骨关节炎中作用的研究进展
Research progress on the role of CD14 in osteoarthritis.
摘要(中文译文)
骨关节炎（OA）是一种以炎症为中心、涉及多细胞协同作用的复杂退行性疾病，其全球疾病负担持续上升。目前的治疗措施主要集中于缓解症状、延缓进展以及终末期关节置换术；尚无疾病修饰或逆转病情的药物，这凸显了剖析炎症驱动机制并确定有效干预靶点的迫切需求。作为一种模式识别受体，CD14在OA微环境中的滑膜巨噬细胞上高表达。它识别内源性损伤相关分子模式，通过TLR4依赖性（MyD88/NF-κB）和TLR4非依赖性（NLRP3炎症小体）两条途径驱动促炎反应。近期研究已积累了大量证据；临床样本和动物模型一致表明，CD14缺失或阻断可减轻软骨损伤、滑膜炎和疼痛，而可溶性CD14（sCD14）水平与炎症细胞因子及临床症状呈正相关，提示其在OA发病机制中的重要作用，并支持其作为生物标志物和治疗靶点的价值。本综述旨在整合现有证据，阐明CD14在OA中的核心促炎作用，并为未来精准靶向治疗和生物标志物驱动的临床试验设计提供理论依据，从而推进OA诊断和治疗策略的发展。
Abstract
Osteoarthritis (OA) is a complex degenerative disease centered on inflammation and involving multi-cellular cooperation, with a continuously rising global burden. Current therapeutic measures mainly focus on symptom relief, slowing progression, and end-stage joint arthroplasty; no disease-modifying or reversal agent is yet available, underscoring the urgent need to dissect the inflammatory driving mechanisms and identify effective intervention targets. As a pattern recognition receptor, CD14 is highly expressed on synovial macrophages in the OA microenvironment. It recognizes endogenous damage-associated molecular patterns, driving pro-inflammatory responses through both TLR4-dependent (MyD88/NF-κB) and TLR4-independent (NLRP3 inflammasome) pathways. Recent studies have accumulated substantial evidence; clinical samples and animal models consistently show that CD14 deficiency or blockade reduces cartilage damage, synovitis, and pain, while soluble CD14 (sCD14) levels positively correlate with inflammatory cytokines and clinical symptoms, indicating its important role in OA pathogenesis and supporting its value as a biomarker and therapeutic target. This review aims to integrate current evidence, clarify the central pro-inflammatory role of CD14 in OA, and provide a theoretical basis for future precision targeted therapies and biomarker-driven clinical trial designs, thereby advancing the development of diagnostic and therapeutic strategies for OA.
如何引用
AMA
Lei Yang, Shuxing Xing. Research progress on the role of CD14 in osteoarthritis.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1824403.
APA
Lei Yang, Shuxing Xing (2026). Research progress on the role of CD14 in osteoarthritis.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1824403
GB/T 7714
Lei Yang, Shuxing Xing. Research progress on the role of CD14 in osteoarthritis.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1824403.
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