心力衰竭及其进展与心外膜脂肪组织中淋巴细胞谱的变化有关
Heart failure and its progression is associated with changed lymphocyte profile in epicardial adipose tissue.
摘要(中文译文)
慢性炎症日益被认为是心力衰竭（HF）发生和进展的关键促进因素，其中心外膜脂肪组织（EAT）作为重要的局部免疫调节器官逐渐受到关注。本研究检测了不同阶段HF患者EAT和皮下脂肪组织（SAT）中的淋巴细胞群体，并与无HF个体进行比较，以阐明其在HF进展中的潜在作用。采用流式细胞术分析了HF D期、HF C期及无HF受试者EAT、SAT和外周血中的淋巴细胞亚群。使用ELISA和Luminex法对循环激素和炎症蛋白进行了定量检测。与HF C期受试者和无HF受试者相比，HF D期受试者EAT中辅助性T细胞（Th）、细胞毒性T细胞（Tc）、自然杀伤T细胞（NKT）和B细胞减少，同时循环中也观察到相应变化。相比之下，HF C期的特征为EAT中Th2和Th17淋巴细胞显著增多，表明HF中间阶段存在活跃的免疫重塑。该阶段还伴有循环中细胞间黏附分子-1水平升高，提示淋巴细胞向脂肪组织的转运增强。在所有研究组中，EAT始终含有比SAT更高比例的促炎性淋巴细胞。综上所述，这些发现表明HF进展伴随着脂肪组织中淋巴细胞组成的动态且阶段依赖性变化，支持了逐渐促炎性的EAT微环境可能促进心肌炎症功能障碍相关HF进展这一概念。
Abstract
Chronic inflammation is increasingly recognized as a key contributor to the development and progression of heart failure (HF), with epicardial adipose tissue (EAT) emerging as an important local immunomodulatory organ. This study examined lymphocyte populations in EAT and subcutaneous adipose tissue (SAT) across different stages of HF and compared them with individuals without HF to clarify their potential role in HF progression. Lymphocyte subsets in EAT, SAT, and peripheral blood were analyzed by flow cytometry in subjects with HF stage D, HF stage C, and subjects without HF. Circulating hormones and inflammatory proteins were quantified using ELISA and Luminex assays. Subjects with HF stage D exhibited a reduction in T helper (Th), cytotoxic T (Tc), natural killer T (NKT), and B cells in EAT compared with both HF stage C subjects and subjects without HF, alongside changes observed in the circulation. In contrast, HF stage C was characterized by a significantly increased presence of Th2 and Th17 lymphocytes in EAT, indicating active immune remodeling during intermediate stages of HF. This stage was also associated with elevated circulating levels of Intracellular Adhesion Molecule-1, suggesting enhanced lymphocyte trafficking into adipose tissue. Across all study groups, EAT consistently contained a higher proportion of pro-inflammatory lymphocytes compared with SAT. Together, these findings demonstrate that HF progression is accompanied by dynamic and stage-dependent changes in lymphocyte composition within adipose tissue, supporting the concept that a progressively pro-inflammatory EAT microenvironment may contribute to myocardial inflammation dysfunction-associated HF progression.
如何引用
AMA
Barbora Judita Kasperova, Anna Cinkajzlova, Daniel Hlavacek, Jakub Mahrik, Ludek Horvath, Iveta Pleyerova, et al. Heart failure and its progression is associated with changed lymphocyte profile in epicardial adipose tissue.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1874851.
APA
Barbora Judita Kasperova, Anna Cinkajzlova, Daniel Hlavacek, Jakub Mahrik, Ludek Horvath, Iveta Pleyerova, et al (2026). Heart failure and its progression is associated with changed lymphocyte profile in epicardial adipose tissue.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1874851
GB/T 7714
Barbora Judita Kasperova, Anna Cinkajzlova, Daniel Hlavacek, Jakub Mahrik, Ludek Horvath, Iveta Pleyerova, et al. Heart failure and its progression is associated with changed lymphocyte profile in epicardial adipose tissue.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1874851.
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