慢性非传染性呼吸道疾病中的自身抗体：范围综述
Autoantibodies in chronic non-infectious respiratory diseases: a scoping review.
摘要(中文译文)
我们开展了一项范围综述，评估慢性非感染性呼吸系统疾病中的自身抗体，包括特发性肺纤维化、特发性间质性肺炎、慢性阻塞性肺疾病、囊性纤维化、哮喘、支气管扩张、结节病和硅肺。检索数据库，纳入从建库至2024年9月13日期间研究上述呼吸系统疾病背景下自身抗体的病例对照研究和队列研究。在识别出的5157条记录中，共纳入79项研究，其中3项研究通过引文审查识别。总体而言，很少有研究对自身抗体进行系统性、无偏倚的检测，大多数研究采用预先设定的靶向方法。文献中同时包含对研究结果进行功能性验证的研究证据有限。尽管与健康对照相比，特定自身抗体与某些呼吸系统疾病之间存在统计学相关性，但除少数已在标准临床实践中应用的自身抗体外，许多新型自身抗体的临床相关性仍不确定。这凸显了当前认识中的重大空白，以及未来通过自身抗体进行内表分型研究的优先领域。本综述总结了慢性非感染性呼吸系统疾病中自身抗体的现有证据状况。
Abstract
We performed a scoping review assessing autoantibodies across chronic non-infectious respiratory diseases including idiopathic pulmonary fibrosis, idiopathic interstitial pneumonias, chronic obstructive pulmonary disease, cystic fibrosis, asthma, bronchiectasis, sarcoidosis, and silicosis. Databases were searched for case-control and cohort studies investigating autoantibodies in the context of these respiratory diseases from inception to 13 September 2024. Of 5157 records identified, 79 studies were included, including three studies identified through citation review. Overall, few studies employed systematic, unbiased investigation of autoantibodies with most taking a predefined targeted approach. There was limited evidence in the literature of studies that also included functional validation of their findings. Despite statistical correlations between specific autoantibodies and certain respiratory diseases compared to healthy controls, the clinical relevance of many novel autoantibodies remains uncertain beyond a small number already utilized in standard clinical practice. This highlights a major gap in current understanding and priority areas for future research for endotyping by autoantibodies. This review summarises the current state of evidence on autoantibodies across chronic non-infectious respiratory diseases.
如何引用
AMA
Ke Li Chow, Matthijs Bekkers, Theo de Malmanche, Kathryn Patchett, Peter A B Wark, Gerard E Kaiko. Autoantibodies in chronic non-infectious respiratory diseases: a scoping review.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1809141.
APA
Ke Li Chow, Matthijs Bekkers, Theo de Malmanche, Kathryn Patchett, Peter A B Wark, Gerard E Kaiko (2026). Autoantibodies in chronic non-infectious respiratory diseases: a scoping review.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1809141
GB/T 7714
Ke Li Chow, Matthijs Bekkers, Theo de Malmanche, Kathryn Patchett, Peter A B Wark, Gerard E Kaiko. Autoantibodies in chronic non-infectious respiratory diseases: a scoping review.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1809141.
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