系统性红斑狼疮中的血小板：从止血盟友到致病驱动因素
Platelets in systemic lupus erythematosus: from hemostatic allies to pathogenic drivers.
摘要(中文译文)
系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病；血液系统受累常见，且与预后密切相关。血小板是外周血中第二丰富的细胞成分，为无核的胞质碎片。其经典作用包括止血、血栓形成和血管修复。近年来，血小板已被认识为固有免疫和适应性免疫的调节因子，可放大炎症信号并可能促进肿瘤播散，提示其在SLE的发生和进展中具有尚未被充分认识的致病作用。本综述综合了血小板在SLE中的病理生物学，并将其组织为四个模块：（i）活化血小板的促炎作用；（ii）血小板来源微粒（PMPs）的致病效应；（iii）血小板加重狼疮性肾炎的机制；（iv）血小板与SLE相关心血管疾病相关联的通路。我们还评估了靶向血小板的治疗策略及其转化前景。我们的目标是提供一个关于血小板-SLE相互作用的连贯框架，为机制研究提供信息、指导生物标志物的开发，并支持更精准的诊断和治疗方案的设计。
Abstract
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease; hematologic involvement is common and strongly associated with prognosis. Platelets-the second most abundant cellular component of peripheral blood-are anucleate cytoplasmic fragments. Their canonical roles include hemostasis, thrombosis, and vascular repair. More recently, platelets have emerged as regulators of innate and adaptive immunity that amplify inflammatory signaling and may facilitate tumor dissemination, suggesting underappreciated pathogenic roles in the initiation and progression of SLE. This review synthesizes platelet pathobiology in SLE and structures it into four modules: (i) pro-inflammatory actions of activated platelets; (ii) pathogenic effects of platelet-derived microparticles (PMPs); (iii) mechanisms by which platelets exacerbate lupus nephritis; and (iv) pathways linking platelets to SLE-associated cardiovascular disease. We also evaluate platelet-targeted therapeutic strategies and their translational prospects. Our aim is to provide a coherent framework for the platelet-SLE interface that informs mechanistic studies, guides biomarker development, and supports the design of more precise diagnostics and therapies.
如何引用
AMA
Yanzuo Wu, Ze Yang, Shuo Huang, Jie Bao, Yongsheng Fan, Guanqun Xie. Platelets in systemic lupus erythematosus: from hemostatic allies to pathogenic drivers.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1778274.
APA
Yanzuo Wu, Ze Yang, Shuo Huang, Jie Bao, Yongsheng Fan, Guanqun Xie (2026). Platelets in systemic lupus erythematosus: from hemostatic allies to pathogenic drivers.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1778274
GB/T 7714
Yanzuo Wu, Ze Yang, Shuo Huang, Jie Bao, Yongsheng Fan, Guanqun Xie. Platelets in systemic lupus erythematosus: from hemostatic allies to pathogenic drivers.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1778274.
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