炎症性肠病中B细胞体液免疫轴的机制重塑和免疫调节功能
Mechanistic remodeling and immunoregulatory functions of the B cell-humoral immunity axis in inflammatory bowel disease.
摘要(中文译文)
炎症性肠病（IBD）是一种免疫介导的疾病，以肠道黏膜慢性炎症为特征，源于多层免疫调控的失调。近年来，B细胞和体液免疫在IBD发病机制中的作用日益受到关注。B细胞通过分化、克隆扩增和抗体产生参与黏膜免疫调节，并与局部三级淋巴结构（TLSs）的形成和结构组织密切相关。除抗原中和作用外，抗体还可通过Fc受体信号传导、补体激活和免疫复合物介导的应答来调节炎症细胞活化和组织损伤。与此同时，肠道屏障完整性和抗原暴露程度对B细胞活化和抗体产生具有关键影响，共同构成局部免疫过程的互联网络。靶向B细胞-体液免疫轴的治疗策略正在兴起，包括B细胞导向疗法、抗体效应途径的调节以及黏膜免疫功能的恢复。尽管不断积累的证据表明这些方法可能在控制炎症和调节免疫应答方面带来获益，但其疗效和适用性因不同策略和患者群体而异。在本综述中，我们系统整合了关于IBD中B细胞分化、局部淋巴组织和体液免疫应答的现有证据。我们提出“B细胞-体液免疫调控轴”作为概念框架，以描绘IBD中的黏膜免疫重塑，旨在推进机制理解并为治疗干预的优化提供依据。
Abstract
Inflammatory bowel disease (IBD) is an immune-mediated disorder characterized by chronic inflammation of the intestinal mucosa, arising from dysregulation across multiple layers of immune control. In recent years, the contribution of B cells and humoral immunity to IBD pathogenesis has gained increasing attention. B cells participate in mucosal immune regulation through differentiation, clonal expansion, and antibody production, and are closely associated with the formation and structural organization of local tertiary lymphoid structures (TLSs). Beyond antigen neutralization, antibodies can modulate inflammatory cell activation and tissue injury via Fc receptor signaling, complement activation, and immune complex-mediated responses. In parallel, intestinal barrier integrity and the extent of antigen exposure critically influence B cell activation and antibody output, forming an interconnected network of local immune processes. Therapeutic strategies targeting the B cell-humoral immunity axis are emerging, including B cell-directed therapies, modulation of antibody effector pathways, and restoration of mucosal immune function. Although accumulating evidence suggests that these approaches may confer benefits in controlling inflammation and modulating immune responses, their efficacy and applicability vary across different strategies and patient populations. In this review, we systematically integrate current evidence on B cell differentiation, local lymphoid organization, and humoral immune responses in IBD. We propose the "B cell-humoral immunity regulatory axis" as a conceptual framework to delineate mucosal immune remodeling in IBD, with the aim of advancing mechanistic understanding and informing the optimization of therapeutic interventions.
如何引用
AMA
Tao Zhang, Zhetan Ren, Hongkun Zhang, Zhengchao Pan, Meng Chen, Siyuan Bu, et al. Mechanistic remodeling and immunoregulatory functions of the B cell-humoral immunity axis in inflammatory bowel disease.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1857614.
APA
Tao Zhang, Zhetan Ren, Hongkun Zhang, Zhengchao Pan, Meng Chen, Siyuan Bu, et al (2026). Mechanistic remodeling and immunoregulatory functions of the B cell-humoral immunity axis in inflammatory bowel disease.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1857614
GB/T 7714
Tao Zhang, Zhetan Ren, Hongkun Zhang, Zhengchao Pan, Meng Chen, Siyuan Bu, et al. Mechanistic remodeling and immunoregulatory functions of the B cell-humoral immunity axis in inflammatory bowel disease.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1857614.
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