胃癌肿瘤微环境中的代谢重编程网络：营养竞争、代谢串扰与免疫抑制的整合轴
Metabolic reprogramming networks in the gastric cancer tumor microenvironment: an integrated axis of nutrient competition, metabolic crosstalk, and immunosuppression.
摘要(中文译文)
胃癌是全球最常见的恶性肿瘤之一，其免疫治疗疗效受到复杂肿瘤微环境（TME）的制约。本综述从网络视角系统阐释了胃癌TME中“营养竞争—代谢串扰—免疫抑制”的动态交互轴。首先，TME的低氧、酸性和营养匮乏条件构成了代谢压力基础，迫使肿瘤细胞与免疫细胞对必需营养物质展开激烈竞争，从而诱导效应T细胞处于代谢剥夺状态。随后，这种竞争态势导致免疫抑制性代谢产物积累，包括乳酸、腺苷、犬尿氨酸和前列腺素E2。这些代谢产物并非单纯的废弃物，而是形成了复杂的代谢串扰网络，通过受体信号传导和表观遗传修饰等机制主动抑制有效的免疫功能并重塑免疫抑制生态位。最终，这一多层次代谢重编程网络共同促进了胃癌的免疫逃逸和免疫治疗耐药。对该网络的全面分析有望为开发新型治疗策略提供重要的理论基础。这些策略可能包括靶向关键代谢节点、缓解免疫抑制以及联合免疫检查点阻断，均有望改善胃癌患者的临床预后。
Abstract
Gastric cancer ranks among the most prevalent malignant tumors globally, with its immunotherapeutic efficacy constrained by the intricate tumor microenvironment (TME). This review provides a systematic elucidation of the dynamic interaction axis of "nutrient competition-metabolic crosstalk-immunosuppression" within the TME of gastric cancer, approached from a network perspective. Initially, the hypoxic, acidic, and nutrient-deficient conditions of the TME establish a metabolic pressure foundation, compelling cancer and immune cells to engage in intense competition for essential nutrients, thereby inducing a state of metabolic deprivation in effector T cells. Subsequently, this competitive dynamic results in the accumulation of immunosuppressive metabolites, including lactic acid, adenosine, kynurenine, and prostaglandin E2. These metabolites, rather than being mere waste products, form a complex metabolic crosstalk network that actively suppresses effective immune function and reshapes the immunosuppressive niche through mechanisms such as receptor signaling and epigenetic modification. Ultimately, this multi-layered metabolic reprogramming network collectively facilitates immune evasion and resistance to immunotherapy in gastric cancer. A comprehensive analysis of the network is anticipated to furnish a vital theoretical foundation for the development of novel therapeutic strategies. These strategies may include targeting pivotal metabolic nodes, alleviating immunosuppression, and integrating immune checkpoint blockade, all of which are expected to enhance the clinical prognosis of patients with gastric cancer.
如何引用
AMA
Xiaona He, Jie Liu, Wenjie Wang. Metabolic reprogramming networks in the gastric cancer tumor microenvironment: an integrated axis of nutrient competition, metabolic crosstalk, and immunosuppression.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1801318.
APA
Xiaona He, Jie Liu, Wenjie Wang (2026). Metabolic reprogramming networks in the gastric cancer tumor microenvironment: an integrated axis of nutrient competition, metabolic crosstalk, and immunosuppression.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1801318
GB/T 7714
Xiaona He, Jie Liu, Wenjie Wang. Metabolic reprogramming networks in the gastric cancer tumor microenvironment: an integrated axis of nutrient competition, metabolic crosstalk, and immunosuppression.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1801318.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出