从饮食到疾病调节：药用食物同源植物在肝纤维化中的多靶点作用
From diet to disease modulation: the multi-targeted effects of medicinal-food homologous plants in hepatic fibrosis.
摘要(中文译文)
肝纤维化是慢性肝病进展中的关键病理阶段，其治疗选择仍然有限。药食同源（MFH）植物因其安全性和生物活性的双重优势而受到认可，具有前景广阔的预防和治疗潜力。本综述系统分析了102种官方批准的MFH植物的抗肝纤维化机制。基于以“特定MFH植物名称”和“肝纤维化或肝脏纤维化”等关键词进行的文献检索，我们筛选出101项相关研究。分析表明，这些植物通过多靶点协同发挥作用，包括减轻氧化应激和炎症、抑制肝星状细胞（HSC）活化、诱导活化HSC凋亡以及调节肠-肝轴。尽管橙皮素、葛根素和姜黄素等生物活性化合物已成为肝纤维化治疗干预的重要候选物，但相关研究在很大程度上仍局限于临床前阶段。此外，约三分之一的证据来源于成分表征不充分的粗提物；活性化合物缺乏系统的药代动力学和毒理学评价；临床研究极为有限；实验剂量远超典型的日常膳食摄入水平。这些局限性严重损害了其临床转化和应用价值。未来研究应着重阐明单一活性化合物的作用机制、建立使用生理相关剂量的长期干预模型，并开展高质量的随机对照试验，从而推动MFH植物从膳食预防向临床治疗的转化。
Abstract
Hepatic fibrosis is a pivotal pathological stage in chronic liver disease progression for which treatment options remain limited. Medicinal-food homologous (MFH) plants, recognized for their dual safety and bioactivity, offer promising preventive and therapeutic potential. This review systematically analyzes the anti-hepatofibrotic mechanisms of 102 officially approved MFH plants. Based on a literature search using keywords such as "specific MFH plant names" and "hepatic fibrosis or liver fibrosis," we identified 101 relevant studies. The analysis reveals that these plants exert their effects through multi-target synergy, mitigating oxidative stress and inflammation, inhibiting hepatic stellate cell (HSC) activation, inducing activated HSC apoptosis, and modulating the gut-liver axis. Although bioactive compounds such as hesperetin, puerarin, and curcumin have emerged as prominent candidates for therapeutic intervention in hepatic fibrosis, related studies remain largely confined to the pre-clinical stage. Furthermore, approximately one-third of the evidence is derived from crude extracts with poorly characterized compositions; active compounds lack systematic pharmacokinetic and toxicological evaluations; clinical studies remain exceptionally limited; and experimental doses far exceed typical daily dietary intake levels. These limitations severely compromise their clinical translation and application value. Future research should focus on elucidating the mechanisms of single active compounds, establishing long-term intervention models using physiologically relevant doses, and conducting high-quality randomized controlled trials, thereby facilitating the translation of MFH plants from dietary prevention to clinical therapy.
如何引用
AMA
Shiqi Chen, Hongdao Chen, Jiaqi Xie, Xiaoyu Peng, Shuhan Yang, Dehui Yin, et al. From diet to disease modulation: the multi-targeted effects of medicinal-food homologous plants in hepatic fibrosis.. Frontiers in nutrition. 2026; doi:10.3389/fnut.2026.1752309.
APA
Shiqi Chen, Hongdao Chen, Jiaqi Xie, Xiaoyu Peng, Shuhan Yang, Dehui Yin, et al (2026). From diet to disease modulation: the multi-targeted effects of medicinal-food homologous plants in hepatic fibrosis.. Frontiers in nutrition. https://doi.org/10.3389/fnut.2026.1752309
GB/T 7714
Shiqi Chen, Hongdao Chen, Jiaqi Xie, Xiaoyu Peng, Shuhan Yang, Dehui Yin, et al. From diet to disease modulation: the multi-targeted effects of medicinal-food homologous plants in hepatic fibrosis.[J]. Frontiers in nutrition, 2026 doi:10.3389/fnut.2026.1752309.
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