急性有氧运动调节尼古丁依赖者与甜味相关的食物偏好：前额叶皮层活动的中介作用

摘要(中文译文)

本研究旨在考察急性有氧运动是否调节尼古丁依赖个体的甜味相关食物偏好，并进一步探讨前额叶皮层活动的潜在中介作用。60名男性尼古丁依赖大学生被随机分配至中等强度运动组、高强度运动组或休息对照组，每组20人。运动组参与者完成40分钟有氧骑行，而对照组在相同时间内安静休息。在干预前和干预后即刻，采用100毫米视觉模拟量表评估甜味相关食物偏好。在视觉食物线索范式下，使用功能性近红外光谱技术记录高甜度食物、低甜度食物和非食物对照条件下前额叶感兴趣区的氧合血红蛋白（HbO）反应。低甜度食物偏好评分存在显著的组×时间交互作用（=0.008），中等强度运动显著增加了对低甜度食物的偏好（<0.001）。在皮层反应方面，中等强度运动显著增强了低甜度食物条件下右侧眶额皮层HbO反应（<0.001）。相关分析显示，在中等强度运动组中，低甜度食物偏好的变化与右侧眶额皮层HbO反应的变化呈正相关（<0.001）。探索性中介分析进一步发现，在中等强度运动与低甜度食物偏好增加之间的关联中，通过右侧眶额皮层HbO反应存在显著的间接效应（=6.56，95% CI [4.29, 9.13]）。中等强度急性有氧运动可能增加尼古丁依赖个体对低甜度食物线索的偏好，右侧眶额皮层HbO反应显示出潜在的部分中介作用。这些发现提供了初步的神经行为学证据，表明急性运动可能影响该人群对低甜度食物线索的评估。

Abstract

This study aimed to examine whether acute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence and to further investigate the potential mediating role of prefrontal cortical activity. Sixty male university students with nicotine dependence were randomly assigned to a moderate-intensity exercise group, a high-intensity exercise group, or a rest control group, with 20 participants in each group. Participants in the exercise groups completed a 40-min aerobic cycling session, whereas those in the control group rested quietly for the same duration. Sweetness-related food preference was assessed using a 100-mm visual analogue scale at pre-intervention and immediate post-intervention. During a visual food cue paradigm, functional near-infrared spectroscopy was used to record oxygenated hemoglobin (HbO) responses in prefrontal regions of interest under high-sweetness food, low-sweetness food, and non-food control conditions. A significant group × time interaction was observed for low-sweetness food preference scores ( = 0.008), with moderate-intensity exercise significantly increasing preference for low-sweetness foods ( < 0.001). For cortical responses, moderate-intensity exercise significantly enhanced right orbitofrontal cortex HbO responses under the low-sweetness food condition ( < 0.001). Correlation analysis showed that changes in low-sweetness food preference were positively associated with changes in right orbitofrontal cortex HbO responses in the moderate-intensity exercise group ( < 0.001). Exploratory mediation analysis further identified a significant indirect effect through right orbitofrontal cortex HbO responses in the association between moderate-intensity exercise and increased low-sweetness food preference ( = 6.56, 95% CI [4.29, 9.13]). Moderate-intensity acute aerobic exercise may increase preference for low-sweetness food cues in individuals with nicotine dependence, with R-OFC HbO responses showing a potential partial mediating role. These findings provide preliminary neurobehavioral evidence that acute exercise may influence low-sweetness food-cue evaluation in this population.

如何引用

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