肝包虫病单细胞转录组测序研究进展

摘要(中文译文)

是一种慢性寄生虫病，也是一种由棘球绦虫成虫或幼虫阶段引起的严重人畜共患感染。该病的传播依赖于作为终末宿主的食肉动物和作为中间宿主的多种动物。根据目前的流行病学报告，肝脏是最常受累的器官。临床上，肝棘球蚴病分为肝泡型棘球蚴病和肝囊型棘球蚴病，两者均严重威胁流行区居民的生活质量。目前，手术治疗联合苯并咪唑类药物治疗是主要治疗手段；然而，可用的化疗药物和靶向治疗药物较少，临床治疗仍存在局限性。因此，迫切需要在分子免疫学和细胞方向上进行新的探索。近年来，随着高通量测序技术的发展，空间转录组学与单细胞转录组学的整合分析在临床研究中变得更加可及，为肝棘球蚴病的研究提供了新途径。本综述聚焦于近年来单细胞RNA测序在肝棘球蚴病中的应用，以及关于分子免疫发病机制、分子诊断、转移、细胞异质性、生长发育以及人类宿主与棘球蚴病相互作用的研究。我们特别关注病灶周围浸润免疫细胞的异质性、细胞亚群分类、免疫抑制和免疫微环境，这有助于临床医生更好地理解肝棘球蚴病的分子免疫机制和生物学特征，为探索新的药物治疗靶点提供参考。

Abstract

is a chronic parasitic disease and a serious zoonotic infection caused by the adult or larval stages of Echinococcus tapeworms. The transmission of depends on carnivores as definitive hosts and various animals as intermediate hosts. According to current epidemiological reports, the liver is the most commonly affected organ. Clinically, Hepatic is classified into hepatic alveolar and hepatic cystic , both of which pose a serious threat to the quality of life of residents in endemic areas. Currently, surgical treatment combined with benzimidazole medication is the main therapy; however, there are few chemotherapeutic drugs and targeted treatments available, and clinical treatment still has limitations. Therefore, there is an urgent need for new exploration in the molecular immunology, cellular directions. In recent years, with the development of high-throughput sequencing technology, integrated analyses of spatial transcriptomics and single-cell transcriptomics have become more accessible in clinical research, providing new approaches for the study of hepatic . This review focuses on the application of single-cell RNA sequencing in hepatic in recent years, as well as research on molecular immunopathogenesis, moleculardiagnostics, metastasis, cellular heterogeneity, growth and development, and the interactions between human hosts and echinococcosis. We pay particularly attentionto the heterogeneity of infiltrating immune cells around lesions, classification of cell subpopulations, immune suppression, and the immune microenvironment, which can help clinicians better understand the molecular immune mechanisms and biological characteristics of hepatic , providing references for exploring new drug therapeutic targets.

如何引用

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