柔性放射性贴片：重塑疤痕和皮肤肿瘤治疗的范式
Flexible Radioactive Patch: Reshaping the Paradigm for Scar and Cutaneous Tumor Treatment.
摘要(中文译文)
皮肤疾病（包括增生性瘢痕和皮肤黑色素瘤）的治疗在临床上仍具有挑战性。传统的用于β射线外照射治疗的放射性核素（如90Sr、32P）敷贴存在结构僵硬的问题，导致脱靶照射、放射性核素分布不均、剂量不一致以及潜在的泄漏风险。为解决这些局限性，我们开发了一种创新的柔性放射性敷贴（32P-RU），通过将负载32P的树脂微球与硼酸修饰的柔性聚二甲基硅氧烷（PBDMS）凝胶（P4U）相结合，实现了对H32PO42-的牢固吸附、均匀分布以及精确、可重复的塑形以贴合不规则病灶。作为一种纯β发射体，32P（最大能量Emax = 1.71 MeV，半衰期T1/2 = 14.28 d，组织穿透深度 = 4 mm）可最大限度减少对邻近正常组织的损伤。在临床前模型中，32P-RU展现出显著的治疗效果：在兔耳增生性瘢痕模型中，五次4 Gy分次照射减小了瘢痕体积并改善了胶原排列；在小鼠皮下黑色素瘤模型中，五次8 Gy分次照射有效抑制了肿瘤生长。值得注意的是，32P-RU与免疫检查点抑制剂（抗PD-L1）联合使用可协同增强抗肿瘤效果，促进树突状细胞成熟、增加CD8+ T细胞浸润，并同时抑制原发肿瘤和远端肿瘤。这种适形、安全且有效的32P-RU敷贴为包括难治性皮肤恶性肿瘤在内的浅表皮肤疾病的精准治疗提供了一种策略。
Abstract
The treatment of skin diseases, including hypertrophic scars and cutaneous melanoma, remains clinically challenging. Conventional radionuclide (e.g., 90Sr, 32P) patches for beta-ray external beam radiotherapy suffer from rigid structures, leading to off-target irradiation, uneven radionuclide distribution, inconsistent dosing, and potential leakage risks. To address these limitations, we developed an innovative, flexible radioactive patch (32P-RU) by integrating 32P-loaded resin microspheres with boric acid-modified flexible polydimethylsiloxane (PBDMS) gel (P4U), enabling robust adsorption of H32PO42-, homogeneous distribution, and precise, repeated reshaping to conform to irregular lesions. As a pure beta emitter, 32P (Emax = 1.71 MeV, T1/2 = 14.28 d, tissue penetration depth = 4 mm) minimizes damage to adjacent normal tissues. In preclinical models, 32P-RU demonstrated significant therapeutic efficacy: in rabbit ear hypertrophic scar models, five 4 Gy fractions reduced scar volume and improved collagen organization; in murine subcutaneous melanoma models, five 8 Gy fractions effectively suppressed tumor growth. Notably, combining 32P-RU with the immune checkpoint inhibitor (anti-PD-L1) synergistically enhanced anti-tumor effect, promoting dendritic cell maturation, increasing CD8+ T cell infiltration, and suppressing both primary and distant tumors. This conformal, safe, and effective 32P-RU patch offers a strategy for the precise treatment of superficial skin diseases, including refractory cutaneous malignancies.
如何引用
AMA
Qian Huang, Jie Wang, Dong Wang, Yu Qin, Xunhao Qi, Qian Chen, et al. Flexible Radioactive Patch: Reshaping the Paradigm for Scar and Cutaneous Tumor Treatment.. ACS applied materials & interfaces. 2026; doi:10.1021/acsami.6c12098.
APA
Qian Huang, Jie Wang, Dong Wang, Yu Qin, Xunhao Qi, Qian Chen, et al (2026). Flexible Radioactive Patch: Reshaping the Paradigm for Scar and Cutaneous Tumor Treatment.. ACS applied materials & interfaces. https://doi.org/10.1021/acsami.6c12098
GB/T 7714
Qian Huang, Jie Wang, Dong Wang, Yu Qin, Xunhao Qi, Qian Chen, et al. Flexible Radioactive Patch: Reshaping the Paradigm for Scar and Cutaneous Tumor Treatment.[J]. ACS applied materials & interfaces, 2026 doi:10.1021/acsami.6c12098.
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