基于3D打印的柔性应变温度双模智能贴片，用于促进伤口愈合和健康监测
Flexible Strain-Temperature Dual-Modal Smart Patch Based on 3D Printing for Wound Healing Promotion and Health Monitoring.
摘要(中文译文)
对于开放性关节创伤患者，术后康复需要实时、可靠地监测生理参数。传统基于弹性体和纺织品的可穿戴传感器常存在力学失配、透气性有限或共形黏附不足等问题，限制了其在创面部位的长期使用。尽管基于水凝胶的传感器具有更好的组织相容性，但其实际应用受到块体结构相关脱水及气体渗透性有限的挑战。在此，我们提出了一种面向应用的水凝胶传感平台，通过整合已有的材料和结构策略来应对这些挑战。利用水/甘油二元溶剂和电解质构建了抗脱水水凝胶体系，以维持长期水合和传感稳定性（>1000 h）。为提高透气性和力学顺应性，通过3D打印制备了网状结构水凝胶传感器。所制备的传感器表现出良好的生物相容性，促进伤口愈合，并在测试条件下实现了具有降低交叉干扰的双模式应变和温度传感。其在47.5-135%应变范围内表现出2.4的应变系数（GF），在22-32 °C温度范围内表现出-4.2% °C的电阻温度系数（TCR）。将该系统集成到无线智能贴片中并结合机器学习，可实现对康复运动模式的实时监测和分类。这项工作展示了面向应用的系统级集成可穿戴监测方案，具有有前景的延长使用潜力。
Abstract
For patients with open joint wounds, postoperative rehabilitation requires real-time and reliable monitoring of physiological parameters. Conventional elastomer- and textile-based wearable sensors often suffer from mechanical mismatch, limited breathability, or insufficient conformal adhesion, restricting their long-term use on wound sites. Although hydrogel-based sensors offer improved tissue compatibility, their practical application is challenged by dehydration and limited gas permeability associated with bulk structures. Here, we present an application-oriented hydrogel sensing platform designed to address these challenges through the integration of established material and structural strategies. A dehydration-resistant hydrogel system is constructed using a water/glycerol binary solvent and electrolyte to maintain long-term hydration and sensing stability (>1000 h). To improve breathability and mechanical compliance, a mesh-structured hydrogel sensor is fabricated via 3D printing. The fabricated sensor demonstrates good biocompatibility, promotes wound healing, and enables dual-mode strain and temperature sensing with reduced cross-interference under the tested conditions. It exhibits a gauge factor (GF) of 2.4 within the strain range of 47.5-135% and a temperature coefficient of resistance (TCR) of -4.2% °C over the temperature range 22-32 °C. Integrated into a wireless smart patch and combined with machine learning, the system allows real-time monitoring and classification of rehabilitation movement patterns. This work demonstrates a system-level, application-driven integration for wearable monitoring with promising extended-use potential.
如何引用
AMA
Chenghan Yi, Zikang Zhang, Siyi Xiang, Jiuchao Qian, Han Jin. Flexible Strain-Temperature Dual-Modal Smart Patch Based on 3D Printing for Wound Healing Promotion and Health Monitoring.. ACS applied materials & interfaces. 2026; doi:10.1021/acsami.6c02676.
APA
Chenghan Yi, Zikang Zhang, Siyi Xiang, Jiuchao Qian, Han Jin (2026). Flexible Strain-Temperature Dual-Modal Smart Patch Based on 3D Printing for Wound Healing Promotion and Health Monitoring.. ACS applied materials & interfaces. https://doi.org/10.1021/acsami.6c02676
GB/T 7714
Chenghan Yi, Zikang Zhang, Siyi Xiang, Jiuchao Qian, Han Jin. Flexible Strain-Temperature Dual-Modal Smart Patch Based on 3D Printing for Wound Healing Promotion and Health Monitoring.[J]. ACS applied materials & interfaces, 2026 doi:10.1021/acsami.6c02676.
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