慢性使用Kratom作为来源不明的栓塞性卒中的潜在危险因素：病例报告
Chronic Kratom Use as a Potential Risk Factor for Embolic Stroke of Undetermined Source: A Case Report.
摘要(中文译文)
卡痛（Kratom）是一种草药补充剂，因其类阿片和兴奋剂作用而日益流行。尽管其使用广泛，美国食品药品监督管理局已就其潜在毒性以及心血管和神经系统并发症风险发出警告。虽然已有多种神经系统效应的报道，但其与缺血性卒中的关联仍不明确。我们报告一例39岁男性，在每日使用卡痛两年后发生不明原因栓塞性卒中（ESUS），无其他可识别的危险因素。该患者表现为大脑中动脉短暂性缺血并自行缓解，MRI显示多发性缺血性梗死灶。广泛的心脏、血管及高凝状态检查均未能发现其他病因。据我们所知，这是首例在长期使用卡痛背景下报告的不明原因栓塞性卒中病例。本病例凸显了长期摄入卡痛与缺血性卒中之间的潜在关联，并强调需要进一步研究以更好地了解其脑血管效应及可能机制。
Abstract
Kratom () is an herbal supplement that has gained popularity for its opioid-like and stimulant effects. Despite its widespread use, the U.S. Food and Drug Administration has issued warnings about its potential toxicity and the risk of cardiovascular and neurological complications. While a range of neurological effects has been reported, its link to ischemic stroke remains unclear. We report a 39-year-old man who developed an embolic stroke of undetermined source (ESUS) after using kratom daily for two years, with no other identifiable risk factors. The patient demonstrated transient ischemia of the middle cerebral artery that resolved spontaneously, associated with multifocal ischemic infarcts on MRI. Extensive cardiac, vascular, and hypercoagulable testing failed to identify an alternative cause. To our knowledge, this is the first reported case of ESUS in the context of chronic kratom use. This case highlights a potential association between long-term kratom consumption and ischemic stroke and underscores the need for further studies to better understand its cerebrovascular effects and possible mechanisms.
如何引用
AMA
Zhuo Luan, Seunghong Rhee, Paisith Piriyawat, Amy H Sim. Chronic Kratom Use as a Potential Risk Factor for Embolic Stroke of Undetermined Source: A Case Report.. Cureus. 2026; doi:10.7759/cureus.111385.
APA
Zhuo Luan, Seunghong Rhee, Paisith Piriyawat, Amy H Sim (2026). Chronic Kratom Use as a Potential Risk Factor for Embolic Stroke of Undetermined Source: A Case Report.. Cureus. https://doi.org/10.7759/cureus.111385
GB/T 7714
Zhuo Luan, Seunghong Rhee, Paisith Piriyawat, Amy H Sim. Chronic Kratom Use as a Potential Risk Factor for Embolic Stroke of Undetermined Source: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.111385.
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