以年轻女性首次躁狂发作为首发症状的格雷夫斯病：病例报告
First Manic Episode With Psychotic Features in a Young Woman as the Initial Presentation of Graves' Disease: A Case Report.
摘要(中文译文)
Graves病可表现为精神症状，尤其是躁狂症状。我们报告一例31岁患者，既往无显著躯体或精神疾病史，因首次躁狂发作入院，表现为情绪不稳、精神运动性激越、失眠但不伴疲乏，并伴有妄想观念。临床检查发现突眼及颈前肿胀。生物学评估显示甲状腺功能亢进，促甲状腺激素（TSH）受抑、游离甲状腺素升高、抗TSH受体抗体阳性，从而诊断为Graves病。患者接受了奥氮平、卡马西平、甲巯咪唑和普萘洛尔联合治疗。临床演变以精神症状迅速改善为特征。本病例强调了在进行彻底临床检查并排除器质性病因之后再作出精神障碍结论的重要性。
Abstract
Graves' disease can manifest with psychiatric symptoms, notably manic symptoms. We report the case of a 31-year-old patient with no notable medical or psychiatric history, admitted for a first manic episode characterized by a labile mood, psychomotor agitation, and insomnia without fatigue, associated with delusional ideas. Clinical examination found exophthalmos with anterior neck swelling. Biological assessment showed hyperthyroidism with suppressed thyroid-stimulating hormone (TSH), elevated free thyroxine, and positive anti-TSH receptor antibodies, leading to the diagnosis of Graves' disease. The patient benefited from treatment combining olanzapine, carbamazepine, methimazole, and propranolol. Clinical evolution was marked by rapid improvement of psychiatric symptoms. This case underlines the importance of performing a thorough clinical examination and excluding organic causes before concluding a psychiatric disorder.
如何引用
AMA
Mohamed Azaouagh, Salah-Eddine El Jabiry, Ismail Moumni, Imane Ramdani, Fatima El Ghazouani, Bouchra Oneib. First Manic Episode With Psychotic Features in a Young Woman as the Initial Presentation of Graves' Disease: A Case Report.. Cureus. 2026; doi:10.7759/cureus.111461.
APA
Mohamed Azaouagh, Salah-Eddine El Jabiry, Ismail Moumni, Imane Ramdani, Fatima El Ghazouani, Bouchra Oneib (2026). First Manic Episode With Psychotic Features in a Young Woman as the Initial Presentation of Graves' Disease: A Case Report.. Cureus. https://doi.org/10.7759/cureus.111461
GB/T 7714
Mohamed Azaouagh, Salah-Eddine El Jabiry, Ismail Moumni, Imane Ramdani, Fatima El Ghazouani, Bouchra Oneib. First Manic Episode With Psychotic Features in a Young Woman as the Initial Presentation of Graves' Disease: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.111461.
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