疑似系统性红斑狼疮患者的急性癫痫发作和失语症：揭示弥漫性半球胶质瘤H3 G34突变的诊断难题
Acute Seizures and Aphasia in a Patient With Suspected Systemic Lupus Erythematosus: A Diagnostic Puzzle Unveiling Diffuse Hemispheric Glioma, H3 G34-Mutant.
摘要(中文译文)
弥漫性半球胶质瘤，H3 G34突变型（DHG-H3-G34），是一种罕见的、新近定义的WHO 4级胶质瘤。其非特异性症状和影像学异质性可模仿感染性、自身免疫性和副肿瘤性神经系统疾病，从而使及时诊断变得复杂。我们报告一例20岁男性患者，有疑似系统性红斑狼疮病史，表现为急性脑病、癫痫发作和失语症。他接受了广泛的检查以评估可能的脑炎。活检最终揭示了DHG-H3-G34的诊断。本病例强调了在急性神经功能下降的年轻患者中保持广泛鉴别诊断的重要性。早期考虑肿瘤对于避免高级别胶质瘤的诊断延迟至关重要。
Abstract
Diffuse hemispheric glioma, H3 G34-mutant (DHG-H3-G34), is a rare, newly defined WHO grade 4 glioma. Its nonspecific symptoms and radiologic heterogeneity can mimic infectious, autoimmune, and paraneoplastic neurologic disorders, complicating timely diagnosis. We present a case of a 20-year-old man with a history of suspected systemic lupus erythematosus who presented with acute encephalopathy, seizures, and aphasia. He underwent an extensive workup to evaluate for possible encephalitis. Biopsy ultimately revealed the diagnosis of DHG-H3-G34. This case highlights the importance of maintaining a broad differential in young patients with acute neurologic decline. Early consideration of neoplasms is crucial to avoid diagnostic delays in high-grade gliomas.
如何引用
AMA
Xiaojun Li, Ibrahim S Tuna, Marie Rivera-Zengotita, Hans Shuhaiber. Acute Seizures and Aphasia in a Patient With Suspected Systemic Lupus Erythematosus: A Diagnostic Puzzle Unveiling Diffuse Hemispheric Glioma, H3 G34-Mutant.. Cureus. 2026; doi:10.7759/cureus.111506.
APA
Xiaojun Li, Ibrahim S Tuna, Marie Rivera-Zengotita, Hans Shuhaiber (2026). Acute Seizures and Aphasia in a Patient With Suspected Systemic Lupus Erythematosus: A Diagnostic Puzzle Unveiling Diffuse Hemispheric Glioma, H3 G34-Mutant.. Cureus. https://doi.org/10.7759/cureus.111506
GB/T 7714
Xiaojun Li, Ibrahim S Tuna, Marie Rivera-Zengotita, Hans Shuhaiber. Acute Seizures and Aphasia in a Patient With Suspected Systemic Lupus Erythematosus: A Diagnostic Puzzle Unveiling Diffuse Hemispheric Glioma, H3 G34-Mutant.[J]. Cureus, 2026 doi:10.7759/cureus.111506.
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